The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Drug development: Through the barrier
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TPT-172 crosses the blood-brain barrier in mice, inferred from similarity to other small pharmacological chaperones.
“Although we do not have data showing that the pharmacological chaperone we used in our study has crossed the blood-brain barrier in our mice, we are confident that this is the case based on the similarity with other small pharmacological chaperones, most of which are predicted to have a good brain permeability [18, 19].”
From Retromer Stabilization Improves Cognitive Function and Synaptic Plasticity in a Mouse Model of Down Syndrome (2023) · cites this paper as [18]
Citations
Cites
Heat shock protein–based therapy as a potential candidate for treating the sphingolipidoses
Kirkegaard, T., Gray, J., Priestman, D. A., Wallom, K.-L., Atkins, J., Olsen, O. D., Klein, A., Drndarski, S., Petersen, N. H. T., Ingemann, L., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad9823 · Cited by 173
Flagged first, then by citations
Cited by
Sorted by citations
Curtis, M. E., Smith, T., Nenov, M., Blass, B. E., & Praticò, D. (2023) · Journal of Alzheimer's Disease · doi:10.3233/jad-230205 · Cited by 3
Metadata
- Authors
- DeWeerdt, S.
- Venue
- Nature
- Published
- 2016-09-21
- Volume
- 537
- Issue
- 7621
- Pages
- S154-S157
- ISSN
- 0028-0836
- 1476-4687
- Cited by
- 8
- References
- 1
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review