Genomics is failing on diversity
DOI 10.1038/538161a
Cited by (1,002)
Items 101–200 of 1,002
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- Polygenic risk scores: a biased prediction?Francisco M. De La Vega, Carlos D. Bustamante · 2018 · Genome Medicine
- A meta-analysis of genetic effects associated with neurodevelopmental disorders and co-occurring conditionsAgnieszka Gidziela, Yasmin Iona Ahmadzadeh, Giorgia Michelini, Andrea G. Allegrini, Jessica C. Agnew‐Blais, Lok Yan Lau, Megan Duret, Francesca Procopio, Emily Daly, Angelica Ronald et al. · 2023 · Nature Human Behaviour
- Single-cell genomics meets human geneticsCuomo, Anna S. E., Nathan, Aparna, Raychaudhuri, Soumya, MacArthur, Daniel G., Powell, Joseph E. · 2023 · Nature Reviews Genetics
- Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestryTim B. Bigdeli, Giulio Genovese, Penelope Georgakopoulos, Jacquelyn Leigh Meyers, Roseann Elizabeth Peterson, Conrad Osamede Iyegbe, Helena Medeiros, Jorge Valderrama, Eric D. Achtyes, Roman Kotov et al. · 2019 · Molecular Psychiatry
- Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular featuresJason J. Pitt, Markus Riester, Yonglan Zheng, Toshio F. Yoshimatsu, Ayodele Sanni, Olayiwola Oluwasola, Artur Veloso, Emma Labrot, Shengfeng Wang, Abayomi Odetunde et al. · 2018 · Nature Communications
- Polygenic Scores for Height in Admixed PopulationsBárbara Domingues Bitarello, Iain Mathieson · 2020 · G3 Genes Genomes Genetics
- ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin responseAdebowale Adeyemo, Norann A. Zaghloul, Guanjie Chen, Ayo Priscille Doumatey, Carmen C. Leitch, Timothy L. Hostelley, Jessica E. Nesmith, Jie Zhou, Amy R. Bentley, Daniel Shriner et al. · 2019 · Nature Communications
- Cohort Profile: East London Genes & Health (ELGH), a community-based population genomics and health study in British Bangladeshi and British Pakistani peopleSarah Finer, Hilary C. Martin, Ahsan Khan, Karen A. Hunt, Beverley MacLaughlin, Zaheer Ahmed, Richard Edmund Ashcroft, Ceri Durham, Daniel G. MacArthur, Mark I. McCarthy et al. · 2019 · International Journal of Epidemiology
- Risk factors predisposing to cardia gastric adenocarcinoma: Insights and new perspectivesEsmat Abdi, Saeid Latifi‐Navid, Saber Zahri, Abbas Yazdanbod, Farhad Pourfarzi · 2019 · Cancer Medicine
- What is White Ignorance?Annette Martín · 2020 · The Philosophical Quarterly
- Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and UgandaAnne Stevenson, Dickens Howard Akena, Rocky E. Stroud, Lukoye Atwoli, Megan Campbell, Lori Beth Chibnik, Edith Kwobah, Symon M. Kariuki, Alicia R. Martin, Victoria Pattison de Menil et al. · 2019 · BMJ Open
- Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancerJinyoung Byun, Younghun Han, Yafang Li, Jun Xia, Erping Long, Jiyeon Choi, Xiangjun Xiao, Meng Zhu, Wen Zhou, Ryan Sun et al. · 2022 · Nature Genetics
- Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populationsMichael Elgart, Genevieve Ray Lyons, Santiago Romero Brufau, Nuzulul Kurniansyah, Jennifer A. Brody, Xiuqing Guo, Henry J. Lin, Laura M. Raffield, Yan Lin Gao, Han Chen et al. · 2022 · Communications Biology
- Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean HispanicsElizabeth Blue, Andréa R. V. R. Horimoto, Shubhabrata Mukherjee, Ellen M. Wijsman, Timothy A. Thornton · 2019 · Alzheimer s & Dementia
- Addressing underrepresentation in genomics research through community engagementAmy A. Lemke, Edward D. Esplin, Aaron J. Goldenberg, Claudia G. Gonzaga-Jauregui, Neil A. Hanchard, Julie N. Harris-Wai, Justin E. Ideozu, Rosario M. Isasi, Andrew Paul Landstrom, Anya E. R. Prince et al. · 2022 · The American Journal of Human Genetics
- Embracing Genetic Diversity to Improve Black HealthAkinyemi Oni‐Orisan, Yusuph Mavura, Yambazi Banda, Timothy A. Thornton, Ronnie Sebro · 2021 · New England Journal of Medicine
- Host and Microbiome Genome-Wide Association Studies: Current State and ChallengesDenis Awany, Imane Allali, Shareefa Dalvie, Sian M. J. Hemmings, Kilaza Samson Mwaikono, Nicholas Ekow Thomford, Andres M. Gomez, Nicola Mulder, Emile Rugamika Chimusa · 2019 · Frontiers in Genetics
- The clinical utility of exome and genome sequencing across clinical indications: a systematic reviewSalma Shickh, Chloe E. Mighton, Elizabeth M. Uleryk, Petros Pechlivanoglou, Yvonne Bombard · 2021 · Human Genetics
- Recommendations on the use and reporting of race, ethnicity, and ancestry in genetic research: Experiences from the NHLBI TOPMed programAlyna Khan, Stephanie M. Gogarten, Caitlin McHugh, Adrienne M. Stilp, Tamar Sofer, Michael Bowers, Quenna Wong, L. Adrienne Cupples, Bertha Hidalgo, Andrew D. Johnson et al. · 2022 · Cell Genomics
- Interpreting polygenic scores, polygenic adaptation, and human phenotypic differencesRosenberg, Noah A, Edge, Michael D, Pritchard, Jonathan K, Feldman, Marcus W · 2019 · Evolution, Medicine, and Public Health
- Warfarin Pharmacogenomics in Diverse PopulationsJustin Kaye, Lauren E. Schultz, Heidi E. Steiner, Rick A. Kittles, Larisa H. Cavallari, Jason H. Karnes · 2017 · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
- A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traitsMingxuan Cai, Jiashun Xiao, Shunkang Zhang, Xiang Wan, Hongyu Zhao, Gang Chen, Can Yang · 2021 · The American Journal of Human Genetics
- Gallstones, Body Mass Index, C‐Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype DataCarol Barahona Ponce, Dominique Scherer, Regina Brinster, Felix Boekstegers, Katherine Marcelain, Valentina Gárate‐Calderón, Bettina Müller, Gonzalo de Toro, Javier Retamales, Olga Barajas et al. · 2020 · Hepatology
- Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individualsDavide Marnetto, Katri Pärna, Kristi Läll, Ludovica Molinaro, Francesco Montinaro, Toomas Haller, Mait Metspalu, Reedik Mägi, Krista Fischer, Luca Pagani · 2020 · Nature Communications
- Artificial intelligence in medicine and the disclosure of risksKiener, Maximilian · 2021 · AI & SOCIETY
- Cultural evolution of genetic heritabilityRyutaro Uchiyama, Rachel Spicer, Michael Muthukrishna · 2021 · Behavioral and Brain Sciences
- HIV-1 and human genetic variationPaul J. McLaren, Jacques Fellay · 2021 · Nature Reviews Genetics
- Type 1 diabetes in diverse ancestries and the use of genetic risk scoresMARIA JOSE REDONDO, Christopher R. Gignoux, Dana Dabelea, William Hagopian, Suna Önengüt-Gümüşcü, Richard A. Oram, Stephen S. Rich · 2022 · The Lancet Diabetes & Endocrinology
- Tread Lightly Interpreting Polygenic Tests of SelectionNovembre, John, Barton, Nicholas H · 2018 · Genetics
- Genomic Predictors of Asthma Phenotypes and Treatment ResponseNatalia Hernandez‐Pacheco, Maria del Mar Pino-Yanes, Carlos Flores · 2019 · Frontiers in Pediatrics
- Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populationsMichelle Daya, Nicholas M. Rafaels, Tonya M. Brunetti, Sameer Chavan, Albert M. Levin, Aniket Shetty, Christopher R. Gignoux, Meher Preethi Boorgula, Genevieve L. Wojcik, Monica Campbell et al. · 2019 · Nature Communications
- Underrepresented Populations in Parkinson's Genetics Research: Current Landscape and Future DirectionsArtur Francisco Schumacher Schuh, Andrei Bieger, Olaitan Okunoye, Kin Ying Mok, Shen‐Yang Lim, Soraya Bardien, Azlina Ahmad‐Annuar, Bruno Lopes Santos‐Lobato, Matheus Zschornack Strelow, Mohamed Salama et al. · 2022 · Movement Disorders
- Meta-analysis of the diagnostic and clinical utility of exome and genome sequencing in pediatric and adult patients with rare diseases across diverse populationsClaudia Ching Yan Chung, Shirley Pik Ying Hue, Nicole Ying Ting Ng, Phoenix Hoi Lam Doong, Annie Tsz-Wai Chu, Brian Hon‐Yin Chung · 2023 · Genetics in Medicine
- Understanding What Information Is Valued By Research Participants, And WhyConsuelo Hopkins Wilkins, Brandy M. Mapes, Rebecca N Jerome, Victoria Villalta‐Gil, Jill M. Pulley, Paul A. Harris · 2019 · Health Affairs
- The transferability of lipid loci across African, Asian and European cohortsKaroline B. Kuchenbaecker, Nikita Telkar, Theresa Reiker, Robin G. Walters, Kuang Lin, Anders Eriksson, Deepti Gurdasani, Arthur Gilly, Lorraine Southam, Emmanouil Tsafantakis et al. · 2019 · Nature Communications
- Use of machine learning in geriatric clinical care for chronic diseases: a systematic literature reviewAvishek Choudhury, Emily Renjilian, Onur Asan · 2020 · JAMIA Open
- Enhancing Recruitment and Retention of Minority Populations for Clinical Research in Pulmonary, Critical Care, and Sleep Medicine: An Official American Thoracic Society Research StatementNeeta Thakur, Stephanie Lovinsky‐Desir, Donna Appell, Christian Bime, Lauren Castro, Juan Carlos Celedon, Juliana Carvalho Ferreira, Maureen George, Yolanda N. Mageto, Arch G. Mainous et al. · 2021 · American Journal of Respiratory and Critical Care Medicine
- Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptationShaohua Fan, Jeffrey P. Spence, Yuanqing Feng, Matthew E.B. Hansen, Jonathan Terhorst, Márcia Holsbach Beltrame, Alessia Ranciaro, Jibril B Hirbo, William R. Beggs, Neil Thomas et al. · 2023 · Cell
- Sex differences in the genetic architecture of depressionHee‐Ju Kang, Yoomi Park, Kyung-Hun Yoo, Ki Tae Kim, Eun-Song Kim, Ju-Wan Kim, Sung‐Wan Kim, Il‐Seon Shin, Jin‐Sang Yoon, Ju Han Kim et al. · 2020 · Scientific Reports
- Using human genetics to improve safety assessment of therapeuticsKeren Carss, Aimée M. Deaton, Alberto Del Río-Espínola, Dorothée Diogo, Mark R. Fielden, Diptee A. Kulkarni, Jonathan G. Moggs, Peter Newham, Matthew R. Nelson, Frank D. Sistare et al. · 2022 · Nature Reviews Drug Discovery
- Equitable Participation in Biobanks: The Risks and Benefits of a “Dynamic Consent” ApproachMegan Prictor, Harriet Teare, Jane S. Kaye · 2018 · Frontiers in Public Health
- Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary DataHuwenbo Shi, Kathryn S. Burch, Ruth Johnson, Malika Kumar Freund, Gleb Kichaev, Nicholas Mancuso, Astrid Marilyn Manuel, Natalie Dong, Bogdan Paşaniuc · 2020 · The American Journal of Human Genetics
- Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architectureLinda Kachuri, Angel C. Y. Mak, Donglei Hu, Celeste S. Eng, Scott Huntsman, Jennifer R. Elhawary, Namrata Gupta, Stacey Gabriel, Shujie Xiao, Kevin L. Keys et al. · 2023 · Nature Genetics
- Opportunities and challenges for the computational interpretation of rare variation in clinically important genesMcInnes, Gregory, Sharo, Andrew G., Koleske, Megan L., Brown, Julia E.H., Norstad, Matthew, Adhikari, Aashish N., Wang, Sheng, Brenner, Steven E., Halpern, Jodi, Koenig, Barbara A. et al. · 2021 · The American Journal of Human Genetics
- Two Novel Susceptibility Loci for Prostate Cancer in Men of African AncestryDavid V. Conti, Kan Wang, Xin Sheng, Jeannette T. Bensen, Dennis J. Hazelett, Michael B. Cook, Sue A. Ingles, Rick A. Kittles, Sara S. Strom, Benjamin A. Rybicki et al. · 2017 · JNCI Journal of the National Cancer Institute
- Defining and Achieving Health Equity in Genomic MedicineSonya Jooma, Michael J. Hahn, Lucia A. Hindorff, Vence L. Bonham · 2019 · Ethnicity & Disease
- Views Of Primary Care Providers On Testing Patients For Genetic Risks For Common Chronic DiseasesDiane Hauser, Aniwaa Owusu Obeng, Kezhen Fei, Michelle A. Ramos, Carol R. Horowitz · 2018 · Health Affairs
- Sequencing Newborns:A Call for Nuanced Use of Genomic TechnologiesJosephine Johnston, John D. Lantos, Aaron J. Goldenberg, Flavia Chen, Erik Parens, Barbara Ann Koenig, members of the NSIGHT Ethics and Policy Advisory Board · 2018 · The Hastings Center Report
- Genetic Predisposition to NeuroblastomaErin K. Barr, Mark A. Applebaum · 2018 · Children
- Will Big Data Close the Missing Heritability Gap?Hwasoon Kim, Alexander Grueneberg, Ana Ines Vazquez, Stephen Hsu, Gustavo de los Campos · 2017 · Genetics
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- Genetic contributions to suicidal thoughts and behaviorsDiBlasi, Emily, Kang, Jooeun, Docherty, Anna R. · 2021 · Psychological Medicine
- The Advantages and Challenges of Diversity in Pharmacogenomics: Can Minority Populations Bring Us Closer to Implementation?Honghong Zhang, Tanima De, Yizhen Zhong, Minoli A. Perera · 2019 · Clinical Pharmacology & Therapeutics
- Risk-based breast cancer screening strategies in womenElaine F. Harkness, Susan Astley, D. Gareth Evans · 2019 · Best Practice & Research Clinical Obstetrics & Gynaecology
- Bridging genomics’ greatest challenge: The diversity gapManuel Corpas, Mkpouto Pius, Crystal Vincent, Heinner Guio, Miriam Victoria Dwek, Shivashankar Hiriyur Nagaraj, Catalina López-Correa, Alice B. Popejoy, Segun Fatumo · 2024 · Cell Genomics
- Toward a New Common SenseIsabella Bakker, Stephen R. Gill, Dillon Wamsley · 2021 · Cambridge University Press eBooks
- Comparative genetic architectures of schizophrenia in East Asian and European populationsSchizophrenia Working Group of the Psychiatric Genomics Consortium, Chia-Yen Chen, Zhiqiang Li, Alicia R. Martin, Julien Bryois, Xixian Ma, Héléna A. Gaspar, Masashi Ikeda, Beben Benyamin, Brielin C. Brown et al. · 2019 · Lancaster EPrints (Lancaster University)
- The role of race and ethnicity in views toward and participation in genetic studies and precision medicine research in the United States: A systematic review of qualitative and quantitative studiesElena R. Fisher, Rebekah J. Pratt, R.P. van Esch, Megan Kocher, Katie Wilson, Whiwon Lee, Heather A. Zierhut · 2019 · Molecular Genetics & Genomic Medicine
- Barriers to clinical adoption of pharmacogenomic testing in psychiatry: a critical analysisCatherine R. Virelli, Ayeshah G. Mohiuddin, James L. Kennedy · 2021 · Translational Psychiatry
- False discovery rate control in genome-wide association studies with population structureMatteo Sesia, Stephen Bates, Emmanuel J. Candès, Jonathan Marchini, Chiara Sabatti · 2021 · Proceedings of the National Academy of Sciences
- The complete and fully-phased diploid genome of a male Han ChineseChentao Yang, Yang Zhou, Yanni Song, Dongya Wu, Yan Zeng, Lei Nie, Panhong Liu, Shilong Zhang, Guangji Chen, Jinjin Xu et al. · 2023 · Cell Research
- Cognitive ability and education: How behavioural genetic research has advanced our knowledge and understanding of their associationMargherita Malanchini, Kaili Rimfeld, Andrea G. Allegrini, Stuart James Ritchie, Robert J. Plomin · 2020 · Neuroscience & Biobehavioral Reviews
- Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traitsGaurav Thareja, Yasser A. Al-Sarraj, Aziz Belkadi, Maryam Al-Motawa, Qatar Genome Project Management, Said I. Ismail, Wadha Al‐Muftah, Radja Messai Badji, Hamdi Mbarek, Dima Darwish et al. · 2021 · Nature Communications
- Sources of gene expression variation in a globally diverse human cohortDylan J. Taylor, Surya B. Chhetri, Michael G. Tassia, Arjun Biddanda, Stephanie M. Yan, Genevieve L. Wojcik, Alexis J. Battle, Rajiv C. McCoy · 2024 · Nature
- From the outside in: biological mechanisms linking social and environmental exposures to chronic disease and to health disparitiesBagby, Susan P., Martin, Damali, Chung, Stephanie T., Rajapakse, Nishadi · 2019 · American Journal of Public Health
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- Genomic Testing for Human Health and Disease Across the Life Cycle: Applications and Ethical, Legal, and Social ChallengesGemma A. Bilkey, Belinda L. Burns, Emily P. Coles, Faye L. Bowman, John P. Beilby, Nicholas Pachter, Gareth S Baynam, Hugh J. S. Dawkins, Kristen J. Nowak, Tarun Stephen Weeramanthri · 2019 · Frontiers in Public Health
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