Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

Umaña, Pablo, Jean–Mairet, Joël, Moudry, Radmila, Amstutz, Hanspeter, Bailey, James E.·1999·Nature Biotechnology

Cited by (764)

Items 601–700 of 764

  1. Mammalian Cell Lines and Glycosylation: A Case Study
    Michael Butler · 2009 · Wiley eBooks
  2. Molecular Engineering III: Fc Engineering
    Matthias Peipp, Thomas D. Beyer, Michael Dechant, Thomas Valerius · 2007
  3. N-glycosylation engineering in chimeric antigen receptor T cells enhances anti-tumor activity
    Elien De Bousser, Nele Festjens, Evelyn Plets, Leander Meuris, Laura Vuylsteke, Daria Fijalkowska, Annelies Van Hecke, Elise Wyseure, Marie Goossens, Laure De Pryck et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  4. Overcoming Resistance to Therapeutic Antibodies by Targeting Fc Receptors
    Emily L. Williams, Sean H. Lim, Stephen A. Beers, Peter Johnson, Jonathan C. Strefford, Martin J. Glennie, Mark Steven Cragg · 2013 · Resistance to targeted anti-cancer therapeutics
  5. Molecular Variants Characterization in Protein Therapeutics Development
    Richard T. Ludwig, Jacob Bongers, Li Tao, Yunping Huang, Jinmei Fu, Wei Wu, Peiran Liu, Hangtian Song, Reb J. Russell · 2013 · Springer eBooks
  6. Monoclonal Antibodies: From Structure to Therapeutic Application
    Rong Deng, Junyi Li, C. Andrew Boswell, Amita Joshi, Chunze Li · 2024 · Springer eBooks
  7. Antibody Glycosylation
    Xiaojie Yu, Kavitha Baruah, Christopher N. Scanlan, Max Crispin · 2013 · Elsevier eBooks
  8. Rapid Antibody Glycoengineering in CHO Cells Via RNA Interference and CGE-LIF N-Glycomics
    Pavlos Kotidis, Masue M. Marbiah, Roberto Donini, Itzcóatl A. Gómez, Ioscani Jiménez del Val, Stuart M. Haslam, Karen Marie Polizzi, Cleo Kontoravdi · 2021 · Methods in molecular biology
  9. Therapeutic Antibodies and Immunologic Conjugates
    Konstantin Dobrenkov, Nai‐Kong V. Cheung · 2020 · Elsevier eBooks
  10. Choice of Cellular Protein Expression System
    David L. Gray, Shyam Subramanian · 2000 · Current Protocols in Protein Science
  11. Optimizing Chinese hamster ovary cell line development via targeted control of N-glycosylation
    Christina S. Alves, Shashi Prajapati · 2015 · Pharmaceutical Bioprocessing
  12. Glycosylation of Recombinant IgG Antibodies and Its Relevance for Therapeutic Applications
    Roy Jefferis · 2002 · Cell engineering
  13. Engineer Medium and Feed for Modulating N-Glycosylation of Recombinant Protein Production in CHO Cell Culture
    Yuzhou Fan, Helene Faustrup Kildegaard, Mikael Rørdam Andersen · 2017 · Methods in molecular biology
  14. Immunoglobulin G Glycosylation in Diseases
    Marija Pezer · 2021 · Experientia supplementum
  15. Protein Glycosylation: Analysis, Characterization, and Engineering
    Mikael Rørdam Andersen, Jong Hyun Nam, Susan T. Sharfstein · 2011 · Encyclopedia of Industrial Biotechnology
  16. Obinutuzumab (Gazyva®), a Novel Glycoengineered Type II CD20 Antibody for the Treatment of Chronic Lymphocytic Leukemia and Non‐Hodgkin's Lymphoma
    Christian Klein, Marina Bacac, Pablo Umaña, Michael Wenger · 2014
  17. Development of antibody-based therapeutics for oncology indications
    Yan Li, Zhenping Zhu · 2006 · Drug Development Research
  18. Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism
    Yin‐Cheng Hsieh, Hong‐Hsiang Guan, Chien-Chih Lin, Teng-Yi Huang, Phimonphan Chuankhayan, Nai-Chi Chen, Nan-Hsuan Wang, Pu-Ling Hu, Yi-Chien Tsai, Yen‐Chieh Huang et al. · 2024 · JACS Au
  19. Genetic insights into across pancreatitis types: the causal influence of immunoglobulin G N-glycosylation variants on disease risk
    Yulin Chen, Xue Li, Ran Lu, Yinchun Lv, Junman Ye, Qiaorong Huang, Wentong Meng, Feiwu Long, Jonas Burman, Xianming Mo et al. · 2024 · Frontiers in Immunology
  20. The Autophagy Inhibitor Bafilomycin Inhibits Antibody-Dependent Natural Killer Cell-Mediated Killing of Breast Carcinoma Cells
    Bede Ákos Máté, Váróczy Csongor Attila, Zsuzsanna Polgár, Gergő Fazekas, Csaba Hegedűs, Endre Kókai, Katalin Éva Kovács, László Virág · 2025 · International Journal of Molecular Sciences
  21. Analysis and Manipulation of Recombinant Glycoproteins Manufactured in Mammalian Cell Culture
    Nigel Jenkins · 2003
  22. Glycomics
    Eoin F. J. Cosgrave, Jayesh J. Kattla, Matthew P. Campbell, Weston B. Struwe, Mark R. Wormald, Pauline Mary Rudd · 2016 · Elsevier eBooks
  23. Human IgG Glycosylation in Inflammation and Inflammatory Disease
    Yusuke Mimura, Roy Jefferis · 2020 · Elsevier eBooks
  24. Plant-Derived Monoclonal Antibodies for Prevention and Treatment of Infectious Disease
    Andrew Hiatt, Kevin J. Whaley, Larry Zeitlin · 2015 · ASM Press eBooks
  25. Glycoengineered Therapeutic Antibodies
    Peter Brünker, Peter Sondermann, Pablo Umaña · 2009 · Cambridge University Press eBooks
  26. Engineering the Secretory Pathway in Mammalian Cells
    Ren‐Wang Peng, Martin Fussenegger · 2009 · Cell engineering
  27. Expression of Human Anti-Rh (D) Monoclonal Antibodies into Different Cell Lines: Influence on their Functional Properties
    Christophe de Romeuf, Christine Gaucher, Arnaud Glacet, Sylvie Jorieux, Philippe Klein, Dominique Bourel · 2004 · Springer eBooks
  28. Glycoengineering: Recombinant Glycoproteins
    Michael J. Betenbaugh, Noboru Tomiya, Someet Narang · 2007 · Elsevier eBooks
  29. Monoclonal Antibodies: From Structure to Therapeutic Application
    Rong Deng, C. Andrew Boswell, Wendy S. Putnam, Meina Tao Tang, Amit Garg, Chunze Li, Shan Chung, Sandhya Girish · 2019 · Springer eBooks
  30. Redesigner drugs
    Alan Dove · 2004 · Nature Biotechnology
  31. An alpha-numeric code for representing N-linked glycan structures in secreted glycoproteins
    Faraaz N.K. Yusufi, Wonjun Park, May May Lee, Dong‐Yup Lee · 2008 · Bioprocess and Biosystems Engineering
  32. New Trends in Drug Discovery
    Gerd Schnorrenberg · 2018 · Wiley eBooks
  33. Glycosylation of Antibody Molecules
    Roy Jefferis · 2014
  34. Selective fluorination of Fc glycans enhances antibody-mediated effector functions
    Xianyang Wang, Margaryta Gomozkova, Siqi Li, B. N. Banerjee, Guanghui Zong, Dominique M. Missiakas, Lai‐Xi Wang · 2026 · Proceedings of the National Academy of Sciences
  35. Plant Glycobiology – a sweet world of lectins, glycoproteins, glycolipids and glycans
    Lannoo, Nausicaä, Els J. M. Van Damme, Cécile Albenne, Élisabeth Jamet · 2015 · Frontiers research topics
  36. Effectors of the Future: Universal Chimeric Antigen Receptor
    Lara Sophie Schlegel, Patrick Schlegel · 2024 · Transfusion Medicine and Hemotherapy
  37. The nonglycosylated variant in therapeutic monoclonal antibodies preferentially forms large aggregates under typical thermal stresses used in forced degradation studies
    Gaoyuan Liu, Jenny Kim Kim, Shuli Tang, Yuetian Yan, Mandi M. Hopkins, Dalia Laredo, Teng‐Chieh Yang, James Mutino, Douglas E. Kamen, Kenneth S. Graham et al. · 2025 · mAbs
  38. Glyco-engineering of Fc Glycans to Enhance the Biological Functions of Therapeutic IgGs
    T. Raju, D. Knight, R. Jordan · 2010 · Springer eBooks
  39. The drug discovery process: From ancient times to the present day
    Benjamin E. Blass · 2021 · Elsevier eBooks
  40. Production of Monoclonal Antibodies in Glycoengineered Pichia pastoris
    Dongxing Zha, Thomas O. Linden, Thomas I. Potgieter · 2011 · Cell engineering
  41. Antibody-Based Targeting of Tumor Vasculature and Stroma
    Katharina Frey, Dario Neri · 2011 · Springer eBooks
  42. Assessment of the interactions between bioprocess conditions and protein glycosylation in antibody- producing mammalian cell cultures
    Ioscani Jiménez del Val · 2012
  43. Generation, Structure, and Function of Antibodies
    Melvyn Little · 2021 · Springer eBooks
  44. Techniques for Developing and Assessing Immune Responses Induced by Synthetic DNA Vaccines for Emerging Infectious Diseases
    Ziyang Xu, Michelle Ho, Devivasha Bordoloi, Sagar B. Kudchodkar, Makan Khoshnejad, Leila B. Giron, Faraz I. Zaidi, Moonsup Jeong, Christine C. Roberts, Young K. Park et al. · 2021 · Methods in molecular biology
  45. Antibody Engineering
    Kin-Ming Lo, Olivier J.P. Léger, Björn M Hock · 2015 · ASM Press eBooks
  46. Future Prospects in Antibody Engineering and Therapy
    Sophie Sibéril, Jean‐Luc Teillaud · 2004 · Springer eBooks
  47. Asparagine-Linked Glycosylational Modifications in Yeast
    Jyh-Ming Wu, Cheng‐Kang Lee, Tsu‐An Hsu · 2006 · Kluwer Academic Publishers eBooks
  48. Cell Products—Antibodies
    John R. Birch · 2000
  49. Letter to the Editor
    Guoqiang Chen, Li Zhang, Yanying Wang, Yumei Guo, Hui Liu, Zhili Li · 2013 · Rapid Communications in Mass Spectrometry
  50. Editorial: Structure, Isotypes, Targets, and Post-translational Modifications of Immunoglobulins and Their Role in Infection, Inflammation and Autoimmunity
    Jean Harb, Bridget Smith Wilson, Sylvie Hermouet · 2020 · Frontiers in Immunology
  51. Antibody Engineering
    Esther M. Yoo, Sherie Leaver Morrison · 2009 · Encyclopedia of Industrial Biotechnology
  52. Dynamic <scp>pH</scp> profiles drive higher cell‐specific and volumetric productivity
    Klaubert, Stephanie R., Chitwood, Dylan G., Peng, Danqia, Redman, Erin, Anderson, Ji Young L., Sandoval, Nicholas R., Harcum, Sarah W. · 2026 · Biotechnology Progress
  53. AANL6 is a new efficient tool to probe non-reducing N-acetylglucosamine of N-linked glycans
    Yanting Su, Yang Li, Tianqing Meng, Bo Xu, He Zhu, Li Zhang, Xueqing Wang, Xiaomei Liu, Hui Zhi Sun · 2023 · Carbohydrate Research
  54. Multi-scale design and optimization of antibody production via flexible nets
    Jorge Lázaro, Teresa Joven, Diana Széliová, Jürgen Zanghellini, Jorge Júlvez · 2025 · Computational and Structural Biotechnology Journal
  55. N-Glycoengineering of insect cells for tri-antennary N-glycan biosynthesis
    Hiroyuki Kajiura, Naokuni Nishiguchi, Reimi Lai Sang Sawada‐Choi, Yuto Sana, Ryo Misaki, Kazuhito Fujiyama · 2026 · Scientific Reports
  56. Analytical Physicochemical and Functional Studies to Compare AryoTrust, a Follow-On Biologics, with the Originator Trastuzumab (Herceptin)
    Khalid Kadhem Al-Kinani, Hussein K. Alkufi, Salam Shanta Taher · 2026 · Pharmaceutics
  57. Crystal Structures of Human IgG-Fc Fragments and Their Complexes with Fcγ Receptors
    Peter Sondermann · 2013 · Springer eBooks
  58. Strategies for Development of Next Generation Antibody-Based Therapeutics
    Mohammad A. Tabrizi, Gadi Gazit Bornstein · 2012 · Springer eBooks
  59. Antibody Therapy of Cancer
    Hossein Borghaei, Liat Binyamin, Igor A. Astsaturov, Louis M. Weiner · 2007 · Humana Press eBooks
  60. Antikörper – neue Krebsmedikamente. Gezielt wirksame Biomedizin
    Max Hasmann, Christian Klein, Georg‐Burkhard Kresse · 2009 · Chemie in unserer Zeit
  61. Glycoengineering and Modeling of Protein N-Glycosylation
    Sandra V. Bennun, Frederick J. Krambeck, Michael J. Betenbaugh · 2009 · Cell engineering
  62. Monoclonal Antibodies for Lymphoma
    Guillaume Cartron, Philippe Solal‐Céligny · 2013 · Humana Press eBooks
  63. Analysis of 2-Aminoacridone-Derivatized Complex Oligosaccharides Using Micellar Electrokinetic Capillary Chromatography and Laser-Induced Fluorescence Detection
    Helen C. Birrell, Patrick Camilleri · 2003 · Humana Press eBooks
  64. The Drug Discovery Process
    Benjamin E. Blass · 2015 · Elsevier eBooks
  65. Cutting back on the carbs
    Vivian H. Trang, Peter D. Senter · 2016 · Proceedings of the National Academy of Sciences
  66. Glycomics
    Eoin F. J. Cosgrave, Weston B. Struwe, Jayesh J. Kattla, Matthew P. Campbell, Mark R. Wormald, Pauline Mary Rudd · 2011 · Elsevier eBooks
  67. Glycosylation analysis
    Christoph Gstöttner, Harleen Kaur, Manfred Wuhrer · 2021 · Elsevier eBooks
  68. Original drugs approved by the Food and Drug Administration (Center for Drug Evaluation and Research) in 2024
    Д. В. Куркин, Осадченко Назар Андреевич, A. R. Makarova, DARIA A. GALKINA, Dmitry Aleksandrovich Bakulin, Olga V. Shatalova, Andrey V. Strygin, Vladimir Ivanovich Petrov, O. V. Marincheva, Yu. V. Gorbunova et al. · 2025 · Pharmacy & Pharmacology
  69. Advancing Protein Therapeutics: Innovations In Rational Drug Design: A Review
    Bhakti. Y. Sabale, Nidhi N. Shimpi, Akash V. Rahinj, Vaibhav V. Bangar · 2025 · Asian Journal of Research in Chemistry
  70. Human IgG Glycosylation in Inflammation and Inflammatory Disease
    Roy Jefferis · 2007 · Elsevier eBooks
  71. Novel Generation of Antibody-Based Therapeutics
    Randall J. Brezski · 2015 · Elsevier eBooks
  72. A tribute to Professor Jay Bailey: A pioneer in biochemical engineering
    Chaitan Khosla, Douglas S. Clark, Wilfred Chen · 2018 · AIChE Journal
  73. Animal Cell Technology: Basic & Applied Aspects
    Shinji Iijima, Nishijima, Ken-Ichi · 2006 · Springer eBooks
  74. Posttranslational Modifications to Improve Biopharmaceuticals
    Gary Walsh · 2013
  75. Characterization of Monoclonal Antibody Variants and Glycosylation
    Ting Zheng, Srinivasa Rao, Jeff S. Rohrer, Christopher A. Pohl · 2012
  76. Production of Antibodies in Plants
    Kevin M. Cox, Jeffrey T. Regan, Jason D. Sterling, Vincent P. M. Wingate, Lynn F. Dickey · 2009
  77. Emerging Alternative Production Systems
    Thomas Jostock · 2007
  78. Functional Glycomics and the Future of Glycomic Drugs
    Ram Sasisekharan, Karthik Viswanathan · 2008 · Wiley eBooks
  79. Impacts of glycans attached to therapeutic glycoproteins
    Seonghun Kim, Ohsuk Kwon, Doo‐Byoung Oh · 2010 · Journal of Plant Biotechnology
  80. 20 The Role of Glycosylation in Engineered Antibodies
    Sherie Leaver Morrison · 2005
  81. Immunomics: Entwicklung einer ESI-MS basierten Methodik zur Differenzierung und Quantifizierung von humanen Immunglobulinen und ihrer Glykosylierung
    Lejon Martens · 2003 · Kölner Universitäts PublikationsServer (Universität zu Köln)
  82. Impact of Process Parameters on Cell Growth, Metabolism and Antibody Glycosylation
    Marija Ivarsson · 2014 · Repository for Publications and Research Data (ETH Zurich)
  83. Overview Of Antibody- Based Therapeutics Present And Future Promise
    Iqbal S. Grewal · 2009 · CRC Press eBooks
  84. Synthesis of Glycopeptides and Glycoproteins
    David P. Gamblin, Eoin Martin Scanlan, Benjamin G. Davis · 2007 · Elsevier eBooks
  85. The Impact beyond Recombinant Antibody: Recent Advances in Understanding the Disease Associated Glycan Alterations in Endogenous Antibodies
    Qun Zhou, Protein Engineering, Sanofi, Framingham, MA, 01701, the United States · 2016 · Journal of Biochemistry and Molecular Biology Research
  86. The History of Therapeutic Monoclonal Antibodies
    Régis Sodoyer · 2016 · Wiley eBooks
  87. Antibody Posttranslational Modifications
    Roy Jefferis · 2016
  88. Protein Engineering: Methods and Applications
    Claire Dobson, William F. Dall’Acqua · 2017 · Methods and principles in medicinal chemistry
  89. Discovery and Development of Obinutuzumab (GAZYVA, GAZYVARO), a Glycoengineered Type II Anti‐CD20 Antibody for the Treatment of Non‐Hodgkin Lymphoma and Chronic Lymphocytic Leukemia
    Christian Klein, Ekkehard Mössner, Marina Bacac, Günter Fingerle‐Rowson, Pablo Umaña · 2018 · Wiley eBooks
  90. Antibody Glycosylation
    Roy Jefferis · 2009
  91. Enhancement of Antibody-dependent Cellular Cytotoxicity by Tandem Fc Multimerization
    Hiroaki Nagashima, Yasuhiko Masuho · 2010 · YAKUGAKU ZASSHI
  92. References
    2012 · Elsevier eBooks
  93. Emerging Alternative Production Systems
    Benjamin Sommer, Holger Laux, André Frenzel, Thomas Jostock · 2014
  94. Monoclonal Antibodies
    Beate Diefenbach‐Streiber, Markus M Enzelberger, Johanna Kölln, Josef Prassler, Michael Tesar · 2010 · Ullmann's Encyclopedia of Industrial Chemistry
  95. Overview Of Antibody- Based Therapeutics Present And Future Promise
    Iqbal S. Grewal · 2009 · CRC Press eBooks
  96. A 2-year calorie restriction intervention reduces glycomic biological age biomarkers
    Tea Pribić, Jayanta Das, Lovorka Đerek, Daniel W. Belsky, Melissa C. Orenduff, Kim M. Huffman, William E. Kraus, Helena Deriš, Jelena Šimunović, Tamara Štambuk et al. · 2024 · medRxiv
  97. Glycoengineering of Monoclonal Antibodies
    Caterina Giorno · 2010
  98. Thirty Years of Monoclonal Antibodies: A Long Way to Pharmaceutical and Commercial Success
    Uwe Gottschalk, Kirsten Mundt · 2005
  99. Empowered Antibodies for Cancer Therapy
    Stephen C. Alley, Simone Jeger, Robert P. Lyon, Django R. Sussman, Peter D. Senter · 2011
  100. Optimization of Fc Domains to Enhance Antibody Therapeutics
    Greg A. Lazar, Aaron K. Chamberlain · 2009 · Cambridge University Press eBooks