Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa
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In the RPE, an additional source of 11-cis-retinal is a pathway with retinal G protein-coupled receptor (RGR) as the key enzyme; RGR preferentially binds all-trans-retinal, and within RGR a photon of light converts all-trans-retinal to 11-cis-retinal.
“In RPE, an additional source of 11-cis-retinal is also a pathway with retinal G protein-coupled receptor (RGR) as the key enzyme. RGR is a RHO homologue, which, contrary to RHO, preferentially binds all-trans-retinal. Within RGR, a photon of light converts all-trans-retinal to 11-cis-retinal, the chromophore of the visual pigments.”
From The Role of Vitamin A in Retinal Diseases (2022) · cites this paper as [56]
RGR, together with RPE65, contributes to the regeneration of 11-cis-retinal.
“Therefore, RGR, together with RPE65, contributes to the regeneration of 11-cis-retinal [55,56,57,58].”
From The Role of Vitamin A in Retinal Diseases (2022) · cites this paper as [56]
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References 11 · Cited by 143
- Authors
- Morimura, H., Saindelle-Ribeaudeau, F., Berson, E. L., & Dryja, T. P.
- Affiliations
- Massachusetts Eye and Ear Infirmary (US)
- ORCID
- Morimura, Hiroyuki
- Venue
- Nature Genetics
- Published
- 1999-12
- Volume
- 23
- Issue
- 4
- Pages
- 393-394
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1607116816
- Cited by
- 143
- References
- 11
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 7 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 6
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (R01EY008683, EY 08683, EY00169)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- retinitis pigmentosa, G protein-coupled receptors, all-trans-retinal, retinal pigment epithelium, Müller cells, photoreceptor degeneration, genetic mutations
- MeSH terms
- Aged, Eye Proteins, Female, Heterozygote, Homozygote, Humans, Male, Mutation, Pedigree, Receptors, Cell Surface, Retinitis Pigmentosa, Rod Opsins, Receptors, G-Protein-Coupled
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