Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

Wong, Kwok-Kin, Chang, Sandy, Weiler, Sarah R., Ganesan, Shridar, Chaudhuri, Jayanta, Zhu, Chengming, Artandi, Steven E., Rudolph, Karl Lenhard +4 more·2000·Nature Genetics

DOI 10.1038/79232

Cited by (309)

Items 101–200 of 309

Stem cells, telomerase and dyskeratosis congenita
Philip J. Mason · 2003 · BioEssays
A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis
Imamura, Shintaro, Uchiyama, Junzo, Koshimizu, Eriko, Hanai, Jun-ichi, Raftopoulou, Christina, Murphey, Ryan D., Bayliss, Peter E., Imai, Yoichi, Burns, Caroline Erter, Masutomi, Kenkichi et al. · 2008 · PLoS ONE
The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction
Nagarajan Kannan, Nazmul Huda, LiRen Tu, Radina Droumeva, Geraldine Aubert, Elizabeth A. Chavez, Ryan R. Brinkman, Peter M. Lansdorp, Joanne T. Emerman, Satoshi Abe et al. · 2013 · Stem Cell Reports
Telomeres and cancer: a tale with many endings
Marı́a A. Blasco · 2003 · Current Opinion in Genetics & Development
PAF promotes stemness and radioresistance of glioma stem cells
Derrick Sek Tong Ong, Baoli Hu, Yan Wing Ho, Charles-Etienne Gabriel Sauvé, Christopher Aaron Bristow, Qianghu Wang, Asha S. Multani, Peiwen Chen, Luigi Nezi, Shan Jiang et al. · 2017 · Proceedings of the National Academy of Sciences
Increased Susceptibility of Vault Poly(ADP-Ribose) Polymerase–Deficient Mice to Carcinogen-Induced Tumorigenesis
Sujna Raval-Fernandes, Valerie A. Kickhoefer, Christina M. Ramirez, Leonard H. Rome · 2005 · Cancer Research
Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer
Samanthi A. Perera, Richard S. Maser, Huili Xia, Kate L. McNamara, Alexei I. Protopopov, Liang Chen, Aram F. Hezel, Carla F. Kim, Roderick Terry Bronson, Diego H. Castrillón et al. · 2008 · Carcinogenesis
The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems
Stefan Tümpel, K. Lenhard Rudolph · 2012 · Annals of the New York Academy of Sciences
Telomere dysfunction: multiple paths to the same end
Lea A. Harrington, Murray O. Robinson · 2002 · Oncogene
Molecular contribution of BRCA1 and BRCA2 to genome instability in breast cancer patients: review of radiosensitivity assays
Fatemeh Sadeghi, Marzieh Asgari, Mojdeh Matloubi, Maral Ranjbar, Nahid Karkhaneh Yousefi, Tahereh Azari, Majid Zaki‐Dizaji · 2020 · Biological Procedures Online
C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p
Chang‐Su Lim, Shahzad I. Mian, Abby F. Dernburg, Judith Campisi · 2001 · Current Biology
Radiation-induced lymphopenia during chemoradiation therapy for non-small cell lung cancer is linked with age, lung V5, and XRCC1 rs25487 genotypes in lymphocytes
Xiaoxue Xie, Steven Hsesheng Lin, James William Welsh, Xiong Wei, Hekun Jin, Radhe Mohan, Zhongxing X. Liao, Ting Xu · 2020 · Radiotherapy and Oncology
Telomere length modulates human radiation sensitivity in vitro
María Castellà, Silvia Puerto, Amadeu Creus, Ricard Marcos, Jordi Surrallés · 2007 · Toxicology Letters
New Insights into the Understanding of Mechanisms of Radiation-Induced Heart Disease
Kaixuan Wang, Cong Ye, Yang Xu, Ping Ma, Yan Chen, Lan Luo · 2023 · Current Treatment Options in Oncology
Non-telomeric activities of telomerase
Jana Majerská, Eva Sýkorová, Jiřı́ Fajkus · 2011 · Molecular BioSystems
Ionizing Radiation Up-regulates Telomerase Activity in Cancer Cell Lines by Post-translational Mechanism via Ras/Phosphatidylinositol 3-Kinase/Akt Pathway
Ron Ram, Orit Uziel, Orit Eldan, Eyal Fenig, Einat Beery, Shelly Lichtenberg, Yardena Nordenberg, Meir Lahav · 2009 · Clinical Cancer Research
Telomeres and telomerase: new targets for the treatment of liver cirrhosis and hepatocellular carcinoma
André Lechel, Michael Peter Manns, K. Lenhard Rudolph · 2004 · Journal of Hepatology
Telomerase: biology and phase I trials
Lloyd R. Kèlland · 2001 · The Lancet Oncology
The telomere/telomerase binding factor PinX1 is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomas
Dong Qian, Bin Zhang, Liru He, Muyan Cai, Shi‐Juan Mai, Yi-Ji Liao, Yan‐Hui Liu, Marie C.M. Lin, Xiu‐Wu Bian, Yi‐Xin Zeng et al. · 2013 · The Journal of Pathology
Association of telomerase activity with radio- and chemosensitivity of neuroblastomas
Simone Wesbuer, Claudia Lanvers‐Kaminsky, Ines Duran-Seuberth, Tobias Bölling, K.-L. Schäfer, Yvonne Braun, Normann A. Willich, Burkhard Greve · 2010 · Radiation Oncology
Potential mechanisms of disease progression and management of advanced-phase chronic myeloid leukemia
Elias Joseph Jabbour, Timothy P. Hughes, Jörge E. Cortes, Hagop M. Kantarjian, Andreas Hochhaus · 2013 · Leukemia & lymphoma/Leukemia and lymphoma
Protection against chromosome degradation at the telomeres
Nathalie Grandin, Michel Charbonneau · 2007 · Biochimie
Telomeric sequences, radiation sensitivity and genomic instability
Simon D Bouffler, Marı́a A. Blasco, R. Cox, P. J. Smith · 2001 · International Journal of Radiation Biology
Telomere Shortening Alters the Kinetics of the DNA Damage Response after Ionizing Radiation in Human Cells
Rachid Drissi, Jing Wu, Yafang Hu, Carol A. Bockhold, Jeffrey S. Dome · 2011 · Cancer Prevention Research
Genome-wide association study identifies genetic susceptibility loci and pathways of radiation-induced acute oral mucositis
Da-Wei Yang, Tong‐Min Wang, Jiangbo Zhang, Xi‐Zhao Li, Yong‐Qiao He, Ruowen Xiao, Wen‐Qiong Xue, Xiao‐Hui Zheng, Pei‐Fen Zhang, Shaodan Zhang et al. · 2020 · Journal of Translational Medicine
Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase
Sofia Luz Vidal-Cardenas, Carol W. Greider · 2009 · Nucleic Acids Research
Telomerase as a Growth-Promoting Factor
Vera A. Gorbunova, Andrei Seluanov · 2003 · Cell Cycle
Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant
François Delhommeau, Antoine Thierry, D. Feneux, Evelyne Lauret, Edwige Leclercq, Marie Hélène Courtier, Françoise Sainteny, William Vainchenker, Annelise Bennaceur Griscelli · 2002 · Oncogene
Telomere Targeting with a New G4 Ligand Enhances Radiation-Induced Killing of Human Glioblastoma Cells
Patrick Merle, Bertrand Evrard, Anne Petitjean, Jean‐Maríe Lehn, Marie‐Paule Teulade‐Fichou, Emmanuel Chautard, Anne De Cian, Lionel Guittat, Phong Lan Thao Tran, Jean‐Louis Mergny et al. · 2011 · Molecular Cancer Therapeutics
DNA damage response, telomere maintenance and ageing in light of the integrative model
Predrag Slijepčević · 2007 · Mechanisms of Ageing and Development
Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?
Julian Barwell, Laurent Pangon, A Georgiou, Zoe Docherty, Ian Kesterton, J Ball, Richard S. Camplejohn, J. Berg, Abraham Aviv, Jeffery P. Gardner et al. · 2007 · British Journal of Cancer
Replication Proteins Influence the Maintenance of Telomere Length and Telomerase Protein Stability
Maria Dahlén, Per Sunnerhagen, Teresa S.‐F. Wang · 2003 · Molecular and Cellular Biology
Telomerase inhibition and the future management of head-and-neck cancer
James Anthony McCaul, Katrina Gordon, Louise Clark, Eric Kenneth Parkinson · 2002 · The Lancet Oncology
Telomeres and Telomerase in Stem Cells during Aging and Disease
Zhenyu Ju, K. Lenhard Rudolph · 2006 · KARGER eBooks
The Pleiotropy of Telomerase against Cell Death
Young Hoon Sung, Yoon Sik Choi, Cheolho Cheong, Han‐Woong Lee · 2005 · Molecules and Cells
Telomere biology: integrating chromosomal end protection with DNA damage response
Predrag Slijepčević, Suliman Al-Wahiby · 2005 · Chromosoma
Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound
Patrick Merle, Marine Gueugneau, Marie‐Paule Teulade‐Fichou, Mélanie Müller-Barthélémy, Simon Amiard, Emmanuel Chautard, Corinne Guetta, Veronique Dedieu, Yves Communal, Jean‐Louis Mergny et al. · 2015 · Scientific Reports
Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs
Ina Patties, Rolf‐Dieter Kortmann, Franziska Menzel, Annegret Glasow · 2016 · Journal of Experimental & Clinical Cancer Research
Telomeres in cancer and aging: lessons from the mouse
Marı́a A. Blasco · 2003 · Cancer Letters
Loss of Telomere Protection: Consequences and Opportunities
Jacqueline J.L. Jacobs · 2013 · Frontiers in Oncology
Chromosome Translocations, Inversions and Telomere Length for Retrospective Biodosimetry on Exposed U.S. Atomic Veterans
Miles J. McKenna, Erin Robinson, Lynn E. Taylor, Christopher Tompkins, Michael N. Cornforth, Steven L. Simon, Susan M. Bailey · 2019 · Radiation Research
Telomere Profiling: Toward Glioblastoma Personalized Medicine
Sylvain Ferrandon, Paul Saultier, Julien Carras, Priscillia Battiston-Montagne, Gersende Alphonse, Michaël Beuve, Céline Malleval, Jérôme Honnorat, Tania L. Slatter, Noelyn Anne Hung et al. · 2012 · Molecular Neurobiology
Telomere erosion is independent of microsatellite instability but related to loss of heterozygosity in gastric cancer
Dian-Chun Fang · 2001 · World Journal of Gastroenterology
Telomerase: not just for the elongation of telomeres
Rodrigo T. Calado, Jichun Chen · 2006 · BioEssays
Telomerase antagonist imetelstat inhibits esophageal cancer cell growth and increases radiation-induced DNA breaks
Xuping Wu, Shirin Smavadati, Katarina Nordfjäll, Krister Karlsson, Fredrik Qvarnström, Martin Simonsson, Michael Bergqvist, Sergei M Gryaznov, Simon Ekman, Ylva Paulsson-Karlsson · 2012 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Telomere loss, not average telomere length, confers radiosensitivity to TK6-irradiated cells
Francesco Berardinelli, Dino Nieri, Antonella Sgura, Caterina Tanzarella, Antonio Antoccia · 2012 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
The role of telomeres in predicting individual radiosensitivity of patients with cancer in the era of personalized radiotherapy
Céline Mirjolet, Romain Boidot, Sébastien Saliques, François Ghiringhelli, P. Maingon, G. Créhange · 2015 · Cancer Treatment Reviews
Molecular adaptation of telomere associated genes in mammals
Claire C. Morgan, Ann M. Mc Cartney, Mark T.A. Donoghue, Noeleen B. Loughran, Charles Spillane, Emma C. Teeling, Mary J. O’Connell · 2013 · BMC Evolutionary Biology
Modeling aging and cancer in the telomerase knockout mouse
Sandy S. Chang · 2005 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
Immunological disorders and DNA repair
Mark O’Driscoll, Penny Ann Jeggo · 2002 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
Radiation sensitivity increases with proliferation‐associated telomere dysfunction in nontransformed human epithelial cells
David Soler, Judit Pampalona, Laura Tusell, Anna Genescà · 2009 · Aging Cell
Efficient inhibition of human telomerase activity by antisense oligonucleotides sensitizes cancer cells to radiotherapy
Xuemei Ji, Conghua Xie, Minghao Fang, Fuxiang Zhou, Wenjie Zhang, Mingsheng Zhang, Yunfeng Zhou · 2006 · Acta Pharmacologica Sinica
Genotoxic risk of ethyl‐paraben could be related to telomere shortening
Francis Finot, Akram Kaddour, Luc Morat, Isabelle Mouche, Narjes Zaguia, Corina Cuceu, D. Souverville, S. Négrault, Olivier Cariou, A. Essahli et al. · 2016 · Journal of Applied Toxicology
Telomere-Binding Protein TPP1 Modulates Telomere Homeostasis and Confers Radioresistance to Human Colorectal Cancer Cells
Lei Yang, Wenbo Wang, Hu Liu, Xiaoxi Yang, Juan Zhong, Zheng Li, Hui Yang, Han Lei, Haijun Yu, Zhengkai Liao et al. · 2013 · PLoS ONE
Telomere shortening: a new prognostic factor for cardiovascular disease post-radiation exposure
Radhia M’kacher, T. Girinsky, Bruno Colicchio, Michelle Ricoul, Alain Dieterlen, Éric Jeandidier, Leonhard Heidingsfelder, Corina Cuceu, Grace Shim, Monika Frenzel et al. · 2014 · Radiation Protection Dosimetry
Naphthalene diimide‐derivatives G‐quadruplex ligands induce cell proliferation inhibition, mild telomeric dysfunction and cell cycle perturbation in U251MG glioma cells
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Telomere length inversely correlates with radiosensitivity in human carcinoma cells with the same tissue background
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Telomere dysfunction: a new player in radiation sensitivity
Anna Genescà, Marta Martı́n, Laura Latre, David Soler, Judit Pampalona, Laura Tusell · 2006 · BioEssays
Is There a Link between Telomere Maintenance and Radiosensitivity?
Predrag Slijepčević · 2004 · Radiation Research
Telomere Dysfunction Increases Cisplatin and Ecteinascidin-743 Sensitivity of Melanoma Cells
Annamaria Biroccio, Chiara Gabellini, Sarah Amodei, Barbara Benassi, Donatella Del Bufalo, Raffaella Elli, Anna Antonelli, Maurizio D’Incalci, Gabriella Zupi · 2003 · Molecular Pharmacology
Suppression of telomere-binding protein TPP1 resulted in telomere dysfunction and enhanced radiation sensitivity in telomerase-negative osteosarcoma cell line
Weiguang Qiang, Wu Qinqin, Fuxiang Zhou, Conghua Xie, Changping Wu, Yunfeng Zhou · 2014 · Biochemical and Biophysical Research Communications
Telomerase antagonist imetelstat increases radiation sensitivity in esophageal squamous cell carcinoma
Xuping Wu, Jing Zhang, Sijun Yang, Zhihui Kuang, Guolei Tan, Gang Yang, Qichun Wei, Zhigang Guo · 2017 · Oncotarget
Cellular senescence, telomere recombination and maintenance
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Telomere dysfunction is related to the intrinsic radio-resistance of human oral cancer cells
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Brief Report: Long-Term Functional Engraftment of Mesenchymal Progenitor Cells in a Mouse Model of Accelerated Aging
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TERRA Expression Levels Do Not Correlate with Telomere Length and Radiation Sensitivity in Human Cancer Cell Lines
Alexandra Smirnova, Riccardo Gamba, Lela Khoriauli, Valerio Vitelli, Solomon G. Nergadze, Elena Giulotto · 2013 · Frontiers in Oncology
Single-Strand DNA-Binding Protein SSB1 Facilitates TERT Recruitment to Telomeres and Maintains Telomere G-Overhangs
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Protection of the genome and central protein-coding sequences by non-coding DNA against DNA damage from radiation
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Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage
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Telomere shortening and ionizing radiation: A possible role in vascular dysfunction?
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Telomere maintenance in clinical medicine
Gary A. Ulaner · 2004 · The American Journal of Medicine
Telomeres and DNA double-strand breaks: ever the twain shall meet?
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Telomere dysfunction results in enhanced organismal sensitivity to the alkylating agent N-methyl-N-nitrosourea.
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Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization
Yue Liu, Rick C. Betori, Joanna Pagacz, Grant B. Frost, Elena V. Efimova, Ding Wu, Donald J. Wolfgeher, Tracy M. Bryan, Scott B. Cohen, Karl A. Scheidt et al. · 2022 · Cell chemical biology
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Radiation Sensitivity and Radiation Necrosis in the Short Telomere Syndromes
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Telomere Maintenance as Therapeutic Target in Embryonal Tumours
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Telomerase as a novel and potentially selective target for cancer chemotherapy
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Human Telomerase Reverse Transcriptase (hTERT): A Target Molecule for the Treatment of Cisplatin-resistant Tumors
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Long but dysfunctional telomeres correlate with chromosomal radiosensitivity in a mouse AML cell line
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