The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
A CD14-independent LPS receptor cluster
Open accessAbstract
Bacterial lipopolysaccharide (LPS), the major structural component of the outer wall of Gram-negative bacteria, is a potent initiator of an inflammatory response and serves as an indicator of bacterial infection. Although CD14 has been identified as the main LPS receptor, accumulating evidence has suggested the possible existence of other functional receptor(s). In this study, using affinity chromatography, peptide mass fingerprinting and fluorescence resonance energy transfer, we have identified four new proteins that form an activation cluster after LPS ligation and are involved in LPS signal transduction. Here we present evidence that implicates heat shock proteins 70 and 90, chemokine receptor 4 and growth differentiation factor 5 as the main mediators of activation by bacterial lipopolysaccharide.
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Cites
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
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Wright, S. D., Ramos, R. A., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,987
Molecular chaperones in cellular protein folding
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Stryer, L. (1978) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.47.070178.004131 · Cited by 2,406
Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction
Chow, J. C., Young, D. W., Golenbock, D. T., Christ, W. J., & Gusovsky, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10689 · Cited by 1,924
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Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)
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Cited by
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4
Pålsson‐McDermott, E. M., & O'Neill, L. A. J. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01976.x · Cited by 1,254
Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster
Triantafilou, M., & Triantafilou, K. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02233-0 · Cited by 730
Self-citationLipopolysaccharide signaling in endothelial cells
Dauphinee, S. M., & Karsan, A. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700366 · Cited by 614
Metadata
- Authors
- Triantafilou, K., Triantafilou, M., & Dedrick, R. L.
- Venue
- Nature Immunology
- Published
- 2001-04
- Volume
- 2
- Issue
- 4
- Pages
- 338-345
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1504160997
- Cited by
- 422
- References
- 40
- FWCI
- 10.74
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
