Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency
Abstract
Increased secretion and levels of ApoB-containing lipoproteins (BLp) commonly occur in familial hyperlipidemia, obesity and diabetes. The plasma phospholipid-transfer protein (PLTP) is known to mediate transfer of phospholipids between BLp and HDL during their intravascular metabolism. To address a possible role of PLTP in dyslipidemia and atherogenesis, we bred mice deficient in the gene encoding PLTP (PLTP-deficient mice) using different hyperlipidemic mouse strains. In ApoB-transgenic and ApoE-deficient backgrounds, PLTP deficiency resulted in reduced production and levels of BLp and markedly decreased atherosclerosis. BLp secretion was diminished in hepatocytes from ApoB-transgenic PLTP-deficient mice, a defect that was corrected when PLTP was reintroduced in adenovirus. The studies reveal a major, unexpected role of PLTP in regulating the secretion of BLp and identify PLTP as a therapeutic target.
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PLTP-deficient mice models exhibited lower plasma lipids and reduced atherosclerosis.
“PLTP-deficient mice models exhibited lower plasma lipids and reduced atherosclerosis.62”
From Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets (2025) · cites this paper as [62]
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- Authors
- Jiang, X.-C., Qin, S., Qiao, C., Kawano, K., Lin, M., Skold, A., Xiao, X., & Tall, A. R.
- Affiliations
- Columbia University (US)
- University of Pittsburgh (US)
- Corresponding author
- Tall, Alan R.
- Venue
- Nature Medicine
- Published
- 2001-07
- Volume
- 7
- Issue
- 7
- Pages
- 847-852
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1551851929
- Cited by
- 256
- References
- 1
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 5 · 2018: 10 · 2017: 2 · 2016: 4 · 2015: 7 · 2014: 7 · 2013: 14 · 2012: 13
- FWCI
- 21.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (P01HL054591, HL 54591)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- phospholipid transfer protein, apolipoprotein B, apolipoprotein B-containing lipoproteins, lipoprotein secretion, atherosclerosis, dyslipidemia, hepatocytes, ApoE-deficient mice, HDL cholesterol, therapeutic target
- MeSH terms
- Animals, Apolipoproteins B, Arteriosclerosis, Cells, Cultured, Lipid Metabolism, Inborn Errors, Mice, Inbred C57BL, Mice, Transgenic, Hepatocytes, Mice
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