The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons
Abstract
Most mammalian central neurons receive synaptic input over complicated dendritic arbors. Therefore, timing of synaptic information should vary with synapse location. However, I report that temporal summation at CA1 pyramidal somata does not depend on the location of synaptic input. This spatial normalization of temporal integration requires a dendritic hyperpolarization-activated current (lh). Shaping of synaptic activity by deactivating a nonuniform lh could counterbalance filtering by dendrites and effectively remove location-dependent variability in temporal integration, thus enhancing synchronization of neuronal populations and functional capabilities of the hippocampal CA1 region.
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“Second, distal EPSPs in CA1 neurons are locally attenuated by the active properties of the dendrites, including the presence of a very high density of HCN1 channels in the distal dendrites, which act as a depolarizing shunt conductance (George et al., 2009; Magee, 1999).”
From Strong CA2 Pyramidal Neuron Synapses Define a Powerful Disynaptic Cortico-Hippocampal Loop (2010) · cites this paper as Magee, 1999
Citations
Cites
Phase relationship between hippocampal place units and the EEG theta rhythm
O'Keefe, J. M., & Recce, M. L. (1993) · Hippocampus · doi:10.1002/hipo.450030307 · Cited by 2,643
K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons
Hoffman, D. A., Magee, J. C., Colbert, C. M., & Johnston, D. (1997) · Nature · doi:10.1038/43119 · Cited by 1,392
Self-citationQueer Current and Pacemaker: The Hyperpolarization-Activated Cation Current in Neurons
Pape, H.-C. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.001503 · Cited by 1,152
Magee, J. C. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07613.1998 · Cited by 981
Self-citationTemporal structure in spatially organized neuronal ensembles: a role for interneuronal networks
Buzsáki, G., & Chrobak, J. J. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80012-3 · Cited by 878
Action potential initiation and backpropagation in neurons of the mammalian CNS
Stuart, G., Spruston, N., Sakmann, B., & Häusser, M. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10075-8 · Cited by 768
Active Properties of Neuronal Dendrites
Johnston, D., Magee, J. C., Colbert, C. M., & Christie, B. R. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001121 · Cited by 608
Self-citationDendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurons.
Rall, W., Burke, R. E., Smith, T., Nelson, P. G., & Frank, K. (1967) · Journal of Neurophysiology · doi:10.1152/jn.1967.30.5.1169 · Cited by 607
Determinants of Voltage Attenuation in Neocortical Pyramidal Neuron Dendrites
Stuart, G. J., & Spruston, N. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03501.1998 · Cited by 527
Maccaferri, G., & McBain, C. J. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021754 · Cited by 503
Research works printed but not linked: 1
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Theta oscillations in the hippocampus
Buzsáki, G. (2002) · Neuron · doi:10.1016/s0896-6273(02)00586-x · Cited by 3,332
Pyramidal neurons: dendritic structure and synaptic integration
Spruston, N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2286 · Cited by 1,688
Hyperpolarization-Activated Cation Currents: From Molecules to Physiological Function
Robinson, R. B., & Siegelbaum, S. A. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142734 · Cited by 1,177
Spike Timing-Dependent Plasticity of Neural Circuits
Dan, Y., & Poo, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.007 · Cited by 1,029
Hyperpolarization-Activated Cation Channels: From Genes to Function
Biel, M., Wahl‐Schott, C., Michalakis, S., & Zong, X. (2009) · Physiological Reviews · doi:10.1152/physrev.00029.2008 · Cited by 1,035
Metadata
- Authors
- Magee, J. C.
- Affiliations
- Louisiana State University (US)
- Corresponding author
- Magee, Jeffrey C.
- ORCID
- Magee, Jeffrey C.
- Venue
- Nature Neuroscience
- Published
- 1999-06
- Volume
- 2
- Issue
- 6
- Pages
- 508-514
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- DOI
- 10.1038/9158
- OpenAlex
- W2020505352
- Cited by
- 617
- References
- 30
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 18 · 2023: 14 · 2022: 19 · 2021: 21 · 2020: 26 · 2019: 14 · 2018: 26 · 2017: 15 · 2016: 22 · 2015: 31 · 2014: 18 · 2013: 33 · 2012: 29
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Update notices
- erratum (1999-09-01)
- Open access
- closed
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS35865)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- hyperpolarization-activated current, dendritic integration, temporal summation, CA1 pyramidal neurons, neuronal synchronization
- MeSH terms
- Animals, Dendrites, Electric Conductivity, Electric Stimulation, Hippocampus, Neurons, Synapses, Time Factors, Rats, Sprague-Dawley, Excitatory Postsynaptic Potentials, Rats
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