Three important components in the regeneration of the cavernous nerve: brain-derived neurotrophic factor, vascular endothelial growth factor and the JAK/STAT signaling pathway.
Open accessAbstract
Retroperitoneal operations, such as radical prostatectomy, often damage the cavernous nerve, resulting in a high incidence of erectile dysfunction. Although improved nerve-sparing techniques have reduced the incidence of nerve injury, and the administration of phosphodiesterase type 5 inhibitors has revolutionized the treatment of erectile dysfunction, this problem remains a considerable challenge. In recent years, scientists have focused on brain-derived neurotrophic factor and vascular endothelial growth factor in the treatment of cavernous nerve injury in rat models. Results showed that both compounds were capable of enhancing the regeneration of the cavernous nerve and that activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway played a major role in the process.
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The JAK/STAT signaling pathway is widely implicated in the proliferation and differentiation of neural stem cells (NSC) throughout central nervous system development, and it is important in controlling hippocampal nerve reorganization.
“The JAK/STAT signaling pathway is widely implicated in the proliferation and differentiation of neural stem cells (NSC) throughout central nervous system development, and it is important in controlling hippocampal nerve reorganization [61].”
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References 62 · Cited by 39
- Authors
- Zhang, H.-Y., Jin, X.-B., & Lue, T. F.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Lue, Tom F
- ORCID
- Lue, Tom F
- Venue
- Asian Journal of Andrology
- Publisher
- Medknow
- Published
- 2010-12-20
- Volume
- 13
- Issue
- 2
- Pages
- 231-235
- ISSN
- 1008-682X (ISSN-L)
- 1745-7262
- PMC
- PMC3739200
- OpenAlex
- W1984061147
- Cited by
- 39
- References
- 62
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Asian Journal of Andrology (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Urology › Urological Disorders and Treatments
- Keywords
- erectile dysfunction, brain-derived neurotrophic factor, vascular endothelial growth factor, JAK/STAT signaling, radical prostatectomy, retroperitoneal surgery, nerve injury, phosphodiesterase-5 inhibitors, nerve-sparing technique
- MeSH terms
- Animals, Humans, Erectile Dysfunction, Male, Models, Neurological, Nerve Regeneration, Penile Erection, Penis, Peripheral Nerves, Prostatectomy, Signal Transduction, Brain-Derived Neurotrophic Factor, Vascular Endothelial Growth Factor A, STAT Transcription Factors, Rats, Janus Kinases, Peripheral Nerve Injuries
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