Hypoxia-regulated microRNAs in human cancer
Open accessAbstract
Hypoxia plays an important role in the tumor microenvironment by allowing the development and maintenance of cancer cells, but the regulatory mechanisms by which tumor cells adapt to hypoxic conditions are not yet well understood. MicroRNAs are recognized as a new class of master regulators that control gene expression and are responsible for many normal and pathological cellular processes. Studies have shown that hypoxia inducible factor 1 (HIF1) regulates a panel of microRNAs, whereas some of microRNAs target HIF1. The interaction between microRNAs and HIF1 can account for many vital events relevant to tumorigenesis, such as angiogenesis, metabolism, apoptosis, cell cycle regulation, proliferation, metastasis, and resistance to anticancer therapy. This review will summarize recent findings on the roles of hypoxia and microRNAs in human cancer and illustrate the machinery by which microRNAs interact with hypoxia in tumor cells. It is expected to update our knowledge about the regulatory roles of microRNAs in regulating tumor microenvironments and thus benefit the development of new anticancer drugs.
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A large number of miRNAs have been identified as being regulated by hypoxia and mediate events such as cell proliferation, differentiation, invasion and metastasis that are relevant to placental biology.
“A large number of miRNAs have been identified from the field of cancer biology as being regulated by hypoxia, and mediate events such as cell proliferation, differentiation, invasion and metastasis that are relevant to placental biology (109, 499).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [499]
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References 65 · Cited by 164
- Authors
- Shen, G., Li, X., Jia, Y.-F., Piazza, G. A., & Xi, Y.
- Affiliations
- University of South Alabama (US)
- Corresponding author
- Xi, Yaguang
- Venue
- Acta Pharmacologica Sinica
- Published
- 2013-02-04
- Volume
- 34
- Issue
- 3
- Pages
- 336-341
- ISSN
- 0253-9756 (ISSN-L)
- 1671-4083
- 1745-7254
- PMC
- PMC3587916
- OpenAlex
- W1976897524
- Cited by
- 164
- References
- 65
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 11 · 2023: 7 · 2022: 12 · 2021: 23 · 2020: 19 · 2019: 13 · 2018: 10 · 2017: 9 · 2016: 16 · 2015: 16 · 2014: 10 · 2013: 6
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Acta Pharmacologica Sinica (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R21CA160280)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- hypoxia, microRNA, HIF-1, tumor microenvironment, cancer, angiogenesis, metastasis, drug resistance, carcinogenesis, gene expression regulation
- MeSH terms
- Gene Expression Regulation, Humans, Neoplasms, Neovascularization, Pathologic, Cell Hypoxia, Up-Regulation, MicroRNAs, Hypoxia-Inducible Factor 1, alpha Subunit
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