The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Studies with bleomycin and misonidazole on aerated and hypoxic cells
Open accessAbstract
Bleomycin is a chemotherapuetic drug used primarily in the treatment of squamous-cell carcinoma, while misonidazole is an effective radiosensitizer and potent cytotoxic agent selectively affecting hypoxic cells. V79 Chinese hamster cells were used to investigate the cytotoxicity of bleomycin (BLM) under aerated and hypoxic conditions as a function of drug concentration. At a lowered temperature of 17.5 degrees C, or at an elevated temperature of 42.5 degrees C, hypoxic cells are more sensitive to killing by BLM than aerated cells. At either of these temperatures, progression through the cell cycle is inhibited. However, at 37.5 degrees C, mimicking a clinical situation, the sensitivies are reversed, and hypoxic cells are appreciably more resistant. Although many factors are involved, the major reason for this is that aerated cells are cycling while hypoxic cells are not. Aerated cells can progress into phases of the cell cycle where they are more sensitive to killing by BLM. Misoinidazole (=Ro-07-0582) was used in combination with BLM, since its mode of action has been shown to be psecific for killing hypoxic cells. It concomitant use with BLM could be of potential use in chemotherapy when confronted with the hypoxic cell component of solid tumours.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It has been known since the 1950s that hypoxia is a crucial mediator of chemo-and radioresistance (Gray et al., 1953;Roizin-Towle & Hall, 1978).”
From Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer (2016) · cites this paper as Roizin-Towle & Hall, 1978
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Combination Chemotherapy in the Treatment of Advanced Hodgkin's Disease
DeVita, V. T., SERPICK, A. A., & CARBONE, P. P. (1970) · Annals of Internal Medicine · doi:10.7326/0003-4819-73-6-881 · Cited by 1,445
New antibiotics, bleomycin A and B.
Umezawa, H., Maeda, K., Takeuchi, T., & Okami, Y. (1966) · PubMed · Cited by 725
Hahn, G. M., Braun, J., & Har-Kedar, I. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.3.937 · Cited by 480
The effects of bleomycin on survival and cell progression in Chinese hamster cells in vitro.
BARRANCO, S. C., & Humphrey, R. M. (1971) · PubMed · Cited by 218
Hypoxic Sensitizers: Radiobiological Studies at the Cellular Level
Hall, E. J., & Roizin-Towle, L. (1975) · Radiology · doi:10.1148/117.2.453 · Cited by 201
Self-citationCHEMICAL RADIOSENSITIZATION OF HYPOXIC CELLS
ADAMS, G. E. (1973) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a070956 · Cited by 180
Stratford, I. J., & Adams, G. E. (1977) · British Journal of Cancer · doi:10.1038/bjc.1977.44 · Cited by 139
Bleomycin Treatment of the Tumors of Penis and Scrotum
Ichikawa, T., Nakano, I., & 広川, 勲. (1969) · The Journal of Urology · doi:10.1016/s0022-5347(17)62235-3 · Cited by 128
Braun, J. G., & Hahn, G. M. (1975) · PubMed · Cited by 112
Ro-07-0582 as a radiosensitizer and cytotoxic agent
Hall, E. J., & Biaglow, J. E. (1977) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(77)90163-8 · Cited by 89
Self-citation
Cited by
Sorted by citations
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
Wigerup, C., Påhlman, S., & Bexell, D. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.009 · Cited by 687
“It has been known since the 1950s that hypoxia is a crucial mediator of chemo- and radioresistance (Gray et al., 1953; Roizin-Towle & Hall, 1978).”
BackgroundHow the Warburg effect supports aggressiveness and drug resistance of cancer cells?
Icard, P., Shulman, S. D., Farhat, D., Steyaert, J., Alifano, M., & Lincet, H. (2018) · Drug Resistance Updates · doi:10.1016/j.drup.2018.03.001 · Cited by 661
Rohwer, N., & Cramer, T. (2011) · Drug Resistance Updates · doi:10.1016/j.drup.2011.03.001 · Cited by 628
Teicher, B. A., Lazo, J. S., & Sartorelli, A. C. (1981) · PubMed · Cited by 555
Hyperthermia in the treatment of cancer
Field, S. B., & Bleehen, N. M. (1979) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(79)80043-2 · Cited by 322
Metadata
- Authors
- Roizin-Towle, L., & Hall, E. J.
- Affiliations
- Columbia University (US)
- ORCID
- Hall, E J
- Venue
- British Journal of Cancer
- Published
- 1978-02
- Volume
- 37
- Issue
- 2
- Pages
- 254-260
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC2009591
- OpenAlex
- W2054043592
- Cited by
- 63
- References
- 20
- Citations by year
- 2025: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2016: 1 · 2015: 3 · 2012: 3
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- British Journal of Cancer (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
- Keywords
- bleomycin, misonidazole, hypoxic cells, radiosensitizers, V79 cells, cell cycle progression, solid tumors, squamous cell carcinoma
- MeSH terms
- Hypoxia, Bleomycin, Cell Line, Cell Survival, Dose-Response Relationship, Drug, Nitroimidazoles, Oxygen, Temperature
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Studies with bleomycin and misonidazole on aerated and hypoxic cells. https://app.cochat.ai/papers/10.1038/bjc.1978.34
- The paper
- Roizin-Towle, L., & Hall, E. J. (1978). Studies with bleomycin and misonidazole on aerated and hypoxic cells. British Journal of Cancer. https://doi.org/10.1038/bjc.1978.34
