The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Transforming growth factor-β 1 as a signal for induction of cell death by apoptosis
Open accessAbstract
Cell death by apoptosis is a major determinant of growth of normal tissues and tumours. The present study aimed to elucidate signal factors involved in its regulation. Epithelial cells in control liver, during regression of cyproterone acetate induced liver hyperplasia, in liver (pre)neoplasia and in uterus undergoing apoptosis in vivo show immunostaining for transforming growth factor beta 1 (TGF-beta 1) as detected by anti-pre(266-278) TGF-beta 1 antibodies. Positive immunostaining is also seen in a few intact cells of hyperplastic, regressing liver apparently preparing for apoptosis, but is virtually not found in hepatocytes of normal or growing liver nor in cells undergoing death by necrosis. Recombinant latency associated protein (rLAP, dimer of the pro-region non-covalently associated with the mature region) complex and mature TGF-beta 1 induce apoptosis in isolated hepatocytes cultured in vitro. These findings suggest an involvement of TGF-beta 1 in the induction of apoptosis in certain epithelia in vivo.
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Cites
Nuñez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J. P., & Korsmeyer, S. J. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.9.3602 · Cited by 899
Cited by
Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo
Hughes, D. E., Wright, K. R., Uy, H. L., Sasaki, A., Yoneda, T., Roodman, D. G., Mundy, G. R., & Dr. Boyce, B. F. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650101008 · Cited by 1,040
Roles of TGF-beta in hepatic fibrosis
Gressner, A. M. (2002) · Frontiers in Bioscience · doi:10.2741/a812 · Cited by 783
Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A., & Akhurst, R. J. (1996) · Cell · doi:10.1016/s0092-8674(00)80127-0 · Cited by 628
Metadata
- Authors
- Bursch, W., Oberhammer, F., Jirtle, R., Askari, M., Sedivy, R., Grasl-Kraupp, B., Purchio, A., & Schulte-Hermann, R.
- Venue
- British Journal of Cancer
- Published
- 1993-03
- Volume
- 67
- Issue
- 3
- Pages
- 531-536
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2066789432
- Cited by
- 172
- References
- 1
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bursch, W., Oberhammer, F., Jirtle, R., Askari, M., Sedivy, R., Grasl-Kraupp, B., Purchio, A., & Schulte-Hermann, R. (1993). Transforming growth factor-β 1 as a signal for induction of cell death by apoptosis. British Journal of Cancer. https://doi.org/10.1038/bjc.1993.98
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
