Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy
Teng, L, Nakada, M, Zhao, S-G, Endo, Y, Furuyama, N, Nambu, E, Pyko, I V, Hayashi, Y +1 more·2011·British Journal of Cancer
Cited by (172)
Items 101–172 of 172
- 5-Aminolevulinic acid-mediated photodynamic activity in patient-derived cholangiocarcinoma organoidsHiroaki Fujiwara, Naminatsu Takahara, Keisuke Tateishi, Mariko Hori Tanaka, Sachiko Kanai, Hiroyuki Kato, Takuma Nakatsuka, Keisuke Yamamoto, Hirofumi Kogure, Junichi Arita et al. · 2020 · Surgical Oncology
- 5-aminolaevulinic acid (5-ALA) accumulates in GIST-T1 cells and photodynamic diagnosis using 5-ALA identifies gastrointestinal stromal tumors (GISTs) in xenograft tumor modelsMakiko Sasaki, Mamoru Tanaka, Hiroshi Ichikawa, Taketo Suzuki, Hirotada Nishie, Keiji Ozeki, Takaya Shimura, Eiji Kubota, Satoshi Tanida, Hiromi Kataoka · 2021 · PLoS ONE
- C5α secreted by tumor mesenchymal stem-like cells mediates resistance to 5-aminolevulinic acid-based photodynamic therapy against glioblastoma tumorspheresJunseong Park, Seung Jae Oh, Jin‐Kyoung Shim, Young Bin Ji, Ju Hyung Moon, Eui Hyun Kim, Yong‐Min Huh, Jin‐Suck Suh, Jong Hee Chang, Su‐Jae Lee et al. · 2022 · Journal of Cancer Research and Clinical Oncology
- Design and synthesis of 5-aminolaevulinic acid/3-hydroxypyridinone conjugates for photodynamic therapy: enhancement of protoporphyrin IX production and photo-toxicity in tumor cellsTao Zhou, Le-Le Shao, Sinan Battah, Chunfeng Zhu, Robert C. Hider, Brandon J. Reeder, Asma Jabeen, Alexander John MacRobert, Gerui Ren, Xinle Liang · 2016 · MedChemComm
- Experience Profiling of Fluorescence-Guided Surgery II: Non-Glioma PathologiesSo Young Ji, Jin Wook Kim, Chul‐Kee Park · 2019 · Brain Tumor Research and Treatment
- TCGA mRNA Expression Analysis of the Heme Biosynthesis Pathway in Diffusely Infiltrating Gliomas: A Comparison of Typically 5-ALA Fluorescent and Non-Fluorescent GliomasMario Mischkulnig, Barbara Kiesel, Daniela Lötsch, Thomas Roetzer-Pejrimovsky, Martin Borkovec, Lisa I. Wadiura, Petra Andreea Mercea, Florian J. Jaklin, Shawn L. Hervey‐Jumper, Karl Rössler et al. · 2020 · Cancers
- Protoporphyrin IX (PpIX) Fluorescence during Meningioma Surgery: Correlations with Histological Findings and Expression of Heme Pathway MoleculesDorothee Cäcilia Spille, Eva Christine Bunk, Christian Thomas, Zeynep Özdemir, Andrea Wagner, Burak Han Akkurt, Manoj Mannil, Werner Paulus, Oliver Martin Grauer, Walter Stummer et al. · 2023 · Cancers
- Visualizing protoporphyrin IX formation in the dura tail of meningiomas by mass spectrometry imagingBenjamin Brokinkel, Sabrina Kröger, Volker Senner, Astrid Jeibmann, Uwe Kärst, Walter Stummer · 2018 · Acta Neurochirurgica
- Loss of ferrochelatase is protective against colon cancer cells: ferrochelatase a possible regulator of the long noncoding RNA H19Rémi Safi, Tala Mohsen‐Kanson, Georges M. Nemer, Batoul Dekmak, Nelly Rubeiz, Marwan Eid El-Sabban, Dany Nassar, Assaad Antoine Eid, Ossama M. Abbas, Abdul‐Ghani Kibbi et al. · 2019 · Journal of Gastrointestinal Oncology
- In Vitro Evaluation of Antimicrobial Photodynamic Therapy Associated with Hydroalcoholic Extracts of Schinopsis brasiliensis Engl.: New Therapeutic PerspectivesAmaro Lafayette Nobre Formiga Filho, Vanda Sanderana Macêdo Carneiro, Emmanuel Albuquerque‐Souza, Ravely Lucena Santos, Maria Helena Chaves de Vasconcelos Catão, Ana Cláudia Dantas de Medeiros · 2015 · Photomedicine and Laser Surgery
- Repeated 5-aminolevulinic acid mediated sonodynamic therapy using magnetic resonance guided focused ultrasound in rat brain tumour modelsSheng‐Kai Wu, Chia‐Lin Tsai, Aisha Mir, Stuart L. Marcus, Kullervo Hynynen · 2025 · Scientific Reports
- Photodynamic Therapy for Glioblastoma: Potential Application of TiO2 and ZnO Nanoparticles as PhotosensitizersEmma Ortiz-Islas, Ma. Elena Manríquez-Ramírez, Pedro Montes, Citlali Ekaterina Rodríguez-Pérez, Elizabeth Ruiz-Sánchez, Karla Carvajal, Victoria Campos‐Peña · 2025 · Pharmaceutics
- FECH Expression Correlates with the Prognosis and Tumor Immune Microenvironment in Clear Cell Renal Cell CarcinomaGuanghui Zhong, Qing Li, Yang Luo, Yufeng Liu, Dawei Liu, Бин Ли, Tao Wang · 2022 · Journal of Oncology
- The sustaining of fluorescence in photodynamic diagnosis after the administration of 5-aminolevulinic acid in carcinogen-induced bladder cancer orthotopic rat model and urothelial cancer cell linesTakuya Owari, Takashi Iwamoto, Satoshi Anai, Makito Miyake, Yasushi Nakai, Shunta Hori, Takeshi Hara, Takuya Ishii, Urara Ota, Kazumasa Torimoto et al. · 2021 · Photodiagnosis and Photodynamic Therapy
- Influence of Corticosteroids and Antiepileptic Drugs on Visible 5-Aminolevulinic Acid Fluorescence in a Series of Initially Suspected Low-Grade Gliomas Including World Health Organization Grade II, III, and IV GliomasLisa Irina Wadiura, Mario Mischkulnig, Arthur Hosmann, Martin Borkovec, Barbara Kiesel, Thomas Roetzer-Pejrimovsky, Petra Andreea Mercea, Julia Furtner, Shawn L. Hervey‐Jumper, Karl Rössler et al. · 2020 · World Neurosurgery
- Fluorescence intensity and bright spot analyses using a confocal microscope for photodynamic diagnosis of brain tumorsTakeshi YONEYAMA, Tetsuyou Watanabe, Hiroyuki Kagawa, Yutaka Hayashi, Mitsutoshi Nakada · 2016 · Photodiagnosis and Photodynamic Therapy
- Immunocytochemical studies on the nuclear ubiquitous casein and cyclin-dependent kinases substrate following 5-aminolevulinicacid-mediated photodynamic therapy on MCF-7 cellsKatarzyna Hotowy, Marta Woźniak, Kamila Duś‐Szachniewicz, Elżbieta Czapińska, Beata J. Osiecka, Małgorzata Krzystek‐Korpacka, Andrzej Bronowicz, Jacek R. Wiśniewski, Andrzej Gamian, Grzegorz Terlecki et al. · 2013 · Photodiagnosis and Photodynamic Therapy
- Correlative analysis of metallomic gene expression and metal ion content within the mouse hippocampusSomayra S. A. Mamsa, Gaewyn Ellison, Julia Köhn‐Gaone, Keea R. Inder-Smith, Cameron W. Evans, Ross M. Graham, Daryl L. Howard, Mark J. Hackett · 2025 · Metallomics
- Comparison of commercial 5-aminolevulinic acid (Gliolan®) and the pharmacy-compounded solution fluorescence in glioblastomaSantiago Garfias-Arjona, Mónica Lara Almunia, Javier Ibáñez, Olga Delgado Sánchez, Priam Villalonga, Ruth Villalonga-Planells, Javier Pierola Lopetegui, Joan Bestard-Escalas, Albert Maimó‐Barceló, Marta Brell Doval · 2019 · Acta Neurochirurgica
- Impact of thiosemicarbazones on the accumulation of PpIX and the expression of the associated genesRobert Gawecki, Katarzyna Malarz, Marta Rejmund, Jarosław Polański, Anna Mrozek‐Wilczkiewicz · 2019 · Journal of Photochemistry and Photobiology B Biology
- Current Applications of 5-ALA in Glioma Diagnostics and TherapyLei Teng, Mitsutoshi Nakada, Yutaka Hayashi, Takeshi YONEYAMA, Shiguang Zhao, Jun-ichiro Ham · 2013 · InTech eBooks
- Erythropoietic protoporphyria a clinical and molecular study from Lebanon: Ferrochelatase a potential tumor suppressor gene in colon cancerHumam N. Kadara, Georges M. Nemer, Rémi Safi, Natalie Rebeiz, Laetitia Daou, D. Delbani, Waed Btadini, Ossama M. Abbas, Mona Tofaili, Fadi Fouad Bitar et al. · 2017 · Clinical Genetics
- Bright spot analysis for photodynamic diagnosis of brain tumors using confocal microscopyTakeshi YONEYAMA, Tetsuyou Watanabe, Sho Tamai, Katsuyoshi Miyashita, Mitsutoshi Nakada · 2019 · Photodiagnosis and Photodynamic Therapy
- Exact Kinetics of Drug Permeation Using Transition Interface SamplingSina Safaei, Lukas Baldauf, Titus S. van Erp, An Ghysels · 2025 · The Journal of Physical Chemistry B
- Magnetically Driven Lasing Microrobots for Precise Photodynamic TherapyXiaoniu Guo, Guocheng Fang, Ningyuan Nie, Tseng Po-Hao, Weian Wang, Zhiyi Yuan, Xiaoxue Xu, Fei Hu, Niancai Peng, Yu-Cheng Chen · 2026 · ACS Nano
- Mitochondrial respiration supports cancer growth independent of OXPHOSChristos Chinopoulos · 2026 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Photodynamic therapy in glioma cell cultureDavid Aebisher, Kacper Rogóż, Zakariya Abdi Yakub, Klaudia Dynarowicz, Angelika Myśliwiec, Wiktoria Mytych, Katarzyna Komosińska‐Vassev, Maciej Misiołek, Aleksandra Kawczyk‐Krupka, Dorota Bartusik‐Aebisher · 2024 · ONCOLOGIE
- 5-Aminolevulinic acid (5-ALA) in paediatric brain tumour surgery—a systematic review and exploration of fluorophore alternativesVictoria Grace Collins, Charvi Kanodia, Qalisya Binti Yahya, Marianna Liistro, Chandrasekaran Kaliaperumal · 2025 · Child s Nervous System
- Evaluation of autofluorescence and photodynamic diagnosis in assessment of bladder lesionsKamil Bochynek, David Aebisher, Monika Gasiorek, Grzegorz Cieślar, Aleksandra Kawczyk‐Krupka · 2020 · Photodiagnosis and Photodynamic Therapy
- Effects of Supplemental Drugs on Hexaminolevulinate (HAL)-Induced PpIX Fluorescence in Bladder Cancer Cell SuspensionsKit Man Chan, Krasimir A. Vasilev, Melanie MacGregor · 2022 · International Journal of Molecular Sciences
- Intraoperative Photodynamic Diagnosis of Brain Tumors Using 5-Aminolevulinic AcidSatoshi Utsuki, Hidehiro Oka, Kiyotaka Fujii · 2011 · InTech eBooks
- Advancements and Technical Considerations for Extracellular Vesicle Isolation and Biomarker Identification in GlioblastomaLuz Milbeth Cumba Garcia, Samantha M. Bouchal, Megan M. J. Bauman, Ian F. Parney · 2023 · Neurosurgery
- Deep proteome investigation of high-grade gliomas reveals heterogeneity driving differential metabolism of 5-aminolevulinic acidSaicharan Ghantasala, Amruth Bhat, Unnati Agarwal, Deeptarup Biswas, Prawesh Bhattarai, Sridhar Epari, Aliasgar V. Moiyadi, Sanjeeva Srivastava · 2023 · Neuro-Oncology Advances
- Depth-resolved imaging of photosensitizer in the rodent brain using fluorescence laminar optical tomographyBrandon Gaitan, Collin T. Inglut, Yi Liu, Yu Chen, Huang‐Chiao Huang · 2020 · Journal of Biomedical Optics
- A patient with scirrhous stomach cancer treated with combination of hyperthermotherapy and 5-aminolevulinic acid (ALA).Mariko Saito, Kazuhito Yano, Takashi Kamigaki, Shigenori Goto · 2013 · PubMed
- Single-Cell Analysis of 5-ALA Intraoperative Labeling Specificity for GlioblastomaZhouzerui Liu, Angeliki Mela, Julia Lynn Furnari, Michael Argenziano, Corina P. Kotidis, Colin P. Sperring, Nelson Humala, Jeffrey N. Bruce, Peter Canoll, Peter A. Sims · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- 5-Aminolevulinic acid-mediated protoporphyrin IX accumulation in the tumor microenvironment of glioma and its implications for 5-aminolevulinic acid-based local tumor therapies: A review of the literatureZeynep Oezdemir, Marco Gallus, Michael Müther, Walter Stummer · 2026 · Neuro-Oncology
- Synthetic Efforts toward the Synthesis of a Fluorinated Analog of 5-Aminolevulinic Acid: Practical Synthesis of Racemic and Enantiomerically Defined 3-Fluoro-5-aminolevulinic AcidGouthami Pashikanti, Lahu N. Chavan, Lanny S. Liebeskind, Mark M. Goodman · 2024 · The Journal of Organic Chemistry
- Three Decades of Photodynamic Therapy for Glioblastoma: A Comprehensive Scientometric AnalysisJiheng Zhang, Xiuwei Yan, Xin Gao, Jiahe Hu, Hongtao Zhao, Cheng-Yun Yang, Lei Xu, Yapeng Niu, Mo Geng, Nan Wang et al. · 2025 · Photodiagnosis and Photodynamic Therapy
- Advances and Technical Standards in NeurosurgeryJohannes Schramm · 2015 · Advances and technical standards in neurosurgery
- Fluorescence and immune-cell infiltration of nonneoplastic, postbrachytherapy brain tissue in 5-ALA–guided resection of recurrent anaplastic meningioma: illustrative caseRishab Ramapriyan, Victoria Elizabeth Clark, _ _, Maria Martinez‐Lage, Brian Hsueh, _ _, Brian Vala Nahed, _ _, William T. Curry, Bryan D. Choi et al. · 2024 · Journal of Neurosurgery Case Lessons
- Molecular Determinants for Photodynamic Therapy Resistance and Improved Photosensitizer Delivery in GliomaDavid Aebisher, Paweł Woźnicki, Magdalena Czarnecka–Czapczyńska, Klaudia Dynarowicz, Ewelina Szliszka, Aleksandra Kawczyk‐Krupka, Dorota Bartusik‐Aebisher · 2024 · International Journal of Molecular Sciences
- In vitro evaluation of the efficacy of photodynamic therapy using 5-ALA on homologous feline mammary tumors in 2D and 3D culture conditions and a mouse subcutaneous model with 3D cultured cellsSiyao Lin, Urara Ota, Hideo Imazato, Kiwamu Takahashi, Masahiro Ishizuka, Tomohiro Osaki · 2024 · Photodiagnosis and Photodynamic Therapy
- Proteomic Analysis Uncovers Enhanced Inflammatory Phenotype and Distinct Metabolic Changes in IDH1 Mutant Glioma CellsSigrid Ravn Berg, Alessandro Brambilla, Lars Hagen, Animesh Sharma, Cathrine Broberg Vågbø, Nina‐Beate Liabakk, Miroslava Kiššová, Miquel Arano Barenys, Magnar Bjørås, SVERRE HELGE TORP et al. · 2025 · International Journal of Molecular Sciences
- Multimodal method of tissue differentiation in neurooncology using Raman spectroscopy, fluorescence and diffuse reflectance spectroscopyIgor D. Romanishkin, Anuar Ospanov, Tatiana A. Savelieva, S.V. Shugay, Sergey A. Goryainov, Galina Valerievna Pavlova, Igor Pronin, В. Б. Лощенов · 2022 · Burdenko s Journal of Neurosurgery
- Fluorescence-Guided Resection of Malignant GliomasWalter Stummer · 2016 · Springer eBooks
- Combination of iron chelator deferoxamine and ABCG2 transporter inhibitor lapatinib for therapeutic enhancement of 5‐aminolevulinic acidJordyn Olsen, Sharayu Chandratre, Lolwah Alsalamah, Daniel Merenich, Kenneth A. Myers, Bin Chen · 2025 · Photochemistry and Photobiology
- Emerging minimally invasive laser and light-based therapies for glioblastoma: a systematic reviewJosé Geraldo Medeiros Netto, Lio Moreira, Rafaella Mafezoni Caetano, Clara Peixoto Cirillo Costa, Lucas Longo Ferreira, Billy McBenedict, BRUNO LIMA PESSOA · 2026 · Frontiers in Oncology
- 18 Brain tumor imaging with ALAHerbert G. Stepp, Oliver Schnell · 2017 · Series in cellular and clinical imaging
- Improving 5-Aminolevulinic acid photodynamic therapy through the modulation of iron metabolismChenhan Li, Shun-ichiro OGURA · 2025 · Photodiagnosis and Photodynamic Therapy
- Recent advances in microbial production of 5-aminolevulinic acid by metabolic engineeringPing Jiang, Mingke Lian, Guiyu Liu, Pengfei Gu · 2025 · 3 Biotech
- Rothia mucilaginosa membrane vesicles stabilize labile iron to alleviate UVB-induced ferroptosisSiyuan Fan, Xinyue Cai, Weiqi Wang, Meiling Wu, Xiaoyao Huang, Feng Ding, Hao Guo, Geng Dou, Haotian Luo, Shuai Shao et al. · 2026 · Cell Host & Microbe
- Is Intraoperative 5-ALA PDD Effective for Brain Tumors Other than Malignant Gliomas!?—5-ALA PDD and Preoperative Image Analysis in Metastatic Brain Tumors—Ryokichi Yagi, Shinji Kawabata, Masao Fukumura, Naoki Omura, Ryo Hiramatsu, Masahiro Kameda, Naokado Ikeda, Naosuke Nonoguchi, Motomasa Furuse, Yoshinaga Kajimoto et al. · 2023 · Nippon Laser Igakkaishi
- Protoporphyrin IX regulates peripheral benzodiazepine receptor associated protein 7 (PAP7) and divalent metal transporter 1 (DMT1) in K562 cellsYasumasa Okazaki, Jonathan Glass · 2017 · Biochemistry and Biophysics Reports
- Noninvasive, Drug Augmented, Ultra Low Intensity Transcranial Light Photodynamic Treatment of Glioblastoma: LIT-PDTRichard Eric Kast, Laura Milla Sanabria, Anton Kast, Erasmo Barros da Silva · 2024 · Preprints.org
- Brain tumor imaging with ALAHerbert G. Stepp, Oliver Schnell · 2017
- Characterising Peritumoural Progression of Glioblastoma using Multimodal MRIJiun‐Lin Yan · 2017 · Apollo (University of Cambridge)
- Photosensitizers for Glioma Therapy – A Role of 5 -Aminolevulinic AcidJunkoh Yamamoto, Takehiro Kitagwa, Ryo Miyaoka, Kohei Suzuki, Takeshi Saito, Yoshiteru Nakano · 2019 · Progress in Neuro-Oncology
- Benefits and Problems of Photodynamic Diagnosis in Brain Tumor TreatmentMasayuki Nitta, Yoshihiro Muragaki · 2020 · Nippon Laser Igakkaishi
- Susceptibility of Malignant Brain Tumors to 5-aminolaevulinic Acid Mediated Photodynamic Therapy: Direct Phototoxicity and Immunological EffectsAngeliki Datsi, Rüdiger V. Sorg · 2020 · Journal of Cancer Immunology
- PPIX-binding Proteins Reveal Porphyrin Synthesis and Ferroptosis LinkJohn Lynch, Yao Wang, Yuxin Li, Kanisha Kavdia, Yu Fukuda, Sabina Ranjit, Camenzind G. Robinson, Christy R. Grace, Youlin Xia, Junmin Peng et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Photodynamic Diagnosis and Therapy for Brain TumorsYu Kawanishi, Hitoshi Fukuda, Tetsuya Ueba · 2022 · Nippon Laser Igakkaishi
- Fluorescence-guided Surgery using 5-Aminolevulinic Acid in Neurosurgery: The Current Situation and Related IssuesJunkoh Yamamoto, Kohei Suzuki, Keita Toh, Ryo Miyaoka, Shohei Nagasaka, Seishiro Takamatsu, Takeru Umemura, Takeshi Saito, Yoshiteru Nakano · 2023 · Nippon Laser Igakkaishi
- Exploratory analyses of factors related to 5-aminolevulinic acid-induced intraoperative hypotension during malignant glioma surgery via literature reviewKyoichi Tomoto, Akihiko Teshigawara, Tomohiro Aoki, Masahiko Itani, Yuzuru Hasegawa, Yuichi Murayama, Toshihide Tanaka · 2025 · Photodiagnosis and Photodynamic Therapy
- Additional file 1 of Mesoporous silica nanoparticles boost aggressive cancer response to hydrophilic chlorin e6-mediated photodynamic therapyAbdel Gaber, Sara A., Herbert G. Stepp, Mahmoud H. Abdel Kader, Mika Lindén · 2024 · Figshare
- 5-Aminolevulinic Acid-Based Radiodynamic Therapy for Malignant Gliomas: A Conceptual Framework for Mitochondria-Centered Mechanisms, Target Cell States and Translational PerspectivesJunkoh Yamamoto · 2026 · Life
- EVT-701 : targeting electron transport chain complex I as therapeutic approach in cancerRaquel Luna Yolba · 2021 · theses.fr (ABES)
- Enhanced accumulation of protoporphyrin IX via SLC6A6 and SLC36A1 sensitizes cisplatin-resistant cells to 5-aminolevulinic acid-based photodynamic therapySayo Horibe, Toru Tanaka, Shoji Kawauchi, Naoto Sasaki, Yoshiyuki Rikitake · 2026 · Photodiagnosis and Photodynamic Therapy
- Tunable Technologies for the Glioma Tumor Microenvironment: A Comprehensive Review on Bench-to-Bedside Neurosurgical AdvancesEshita Sharma, Julieta Serobyan, Numa Rajab, Aisha Rizwan Ahmed, Santosh Guru, Michael K. Lim · 2026 · Brain Sciences
- A Sequence-Dependent Combination of Photodynamic Therapy and Carboxyamidotriazole Orotate for Enhanced Treatment of GlioblastomaJ U N T A O Qiu, YJ Li, Jiaming Zou, Yucheng Wang, Rui Jü, Lei Guo · 2026 · International Journal of Molecular Sciences
- Targeting the Heme biosynthesis pathway: strategies to enhance 5-ALA-mediated photodynamic therapyJinhui Ren, Yinghui Li, Jiani Fu, Rubing Zhou, Changjun Zhang, Yuanyuan Xie · 2026 · Bioorganic & Medicinal Chemistry Letters
- Biopolymer‐Based Polyelectrolyte Nanoplatforms for Targeted Photodynamic Therapy of Breast CancerAthira Narayanan, Benedetta Di Chiara Stanca, Daniela Pinheiro, Laura Giannotti, Fabrizio Damiano, André Ferreira Moreira, Sónia P. Miguel, Leonardo Lamanna, Eleonora Stanca, Maria Grazia Raucci et al. · 2026 · Open Research (University of Surrey)