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Cited by 38Ovarian cancer diagnosis and treatmentGene expression and cancer classificationBreast Cancer Treatment Studies

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A seven-gene prognostic model for platinum-treated ovarian carcinomas

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Sabatier, R, Finetti, P, Bonensea, J, Jacquemier, J, Adelaide, J, Lambaudie, E, Viens, P, Birnbaum, D, Bertucci, F·2011·British Journal of Cancer
DOI 10.1038/bjc.2011.219PMC PMC3142802
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Abstract

BACKGROUND: Prognosis of ovarian carcinoma is poor, heterogeneous, and not accurately predicted by histoclinical features. We analysed gene expression profiles of ovarian carcinomas to identify a multigene expression model associated with survival after platinum-based therapy. METHODS: Data from 401 ovarian carcinoma samples were analysed. The learning set included 35 cases profiled using whole-genome DNA chips. The validation set included 366 cases from five independent public data sets. RESULTS: Whole-genome unsupervised analysis could not distinguish poor from good prognosis samples. By supervised analysis, we built a seven-gene optimal prognostic model (OPM) out of 94 genes identified as associated with progression-free survival. Using the OPM, we could classify patients in two groups with different overall survival (OS) not only in the learning set, but also in the validation set. Five-year OS was 57 and 27% for the predicted 'Favourable' and 'Unfavourable' classes, respectively. In multivariate analysis, the OPM outperformed the individual current prognostic factors, both in the learning and the validation sets, and added independent prognostic information. CONCLUSION: We defined a seven-gene model associated with outcome in 401 ovarian carcinomas. Prospective studies are warranted to confirm its prognostic value, and explore its potential ability for better tailoring systemic therapies in advanced-stage tumours.

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    “Oprin has a metalloproteinase inhibitor function and is similar to TIMP (tissue inhibitor of metalloproteinase), which can have a role in angiogenesis, cellular proliferation, and tumour progression (Chirco et al, 2006).”
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Metadata

Authors
Sabatier, R., Finetti, P., Bonensea, J., Jacquemier, J., Adelaide, J., Lambaudie, E., Viens, P., Birnbaum, D., & Bertucci, F.
Affiliations
Inserm (FR)
Corresponding author
Bertucci, F
ORCID
Venue
British Journal of Cancer
Publisher
Springer Science and Business Media LLC
Published
2011-06-07
Volume
105
Issue
2
Pages
304-311
ISSN
  • 0007-0920 (ISSN-L)
  • 1532-1827
DOI
10.1038/bjc.2011.219
PMC
PMC3142802
OpenAlex
W2030328721
Cited by
38
References
1
Citations by year
2024: 3 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 1 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 1 · 2012: 2
FWCI
2.87
Type
journal article
Language
en
Open access
Licence
Locations
  • British Journal of Cancer (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Association pour la Recherche sur le Cancer
  • Institut National de la Santé et de la Recherche Médicale
  • Ligue Contre le Cancer
Topics
  • Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
ovarian carcinoma, prognostic gene signature, platinum-based chemotherapy, progression-free survival, overall survival, gene expression profiling, survival prediction, personalized treatment
MeSH terms
Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Decision Support Techniques, Female, Humans, Middle Aged, Ovarian Neoplasms, Prognosis, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Treatment Outcome, Platinum Compounds, Gene Expression Profiling, Microarray Analysis, Genes, Neoplasm, Biomarkers, Pharmacological

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