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Comparison of the prognostic value of inflammation-based prognostic scores in patients with hepatocellular carcinoma

Open access
Kinoshita, A, Onoda, H, Imai, N, Iwaku, A, Oishi, M, Fushiya, N, Koike, K, Nishino, H, Tajiri, H·2012·British Journal of Cancer

Abstract

BACKGROUND: Inflammation-based prognostic scores including the Glasgow Prognostic Score (GPS), neutrophil to lymphocyte ratio (NLR), and Prognostic Nutritional Index (PNI) are associated with survival in patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the prognostic value of these inflammation-based prognostic scores in patients with HCC. METHODS: In total, 150 patients with newly diagnosed HCC were prospectively evaluated. Patients were divided according to the GPS, modified GPS, NLR, platelet to lymphocyte ratio (PLR), Prognostic Index (PI), and PNI. The area under the receiver operating characteristics curve (AUC) was calculated to compare the predictive ability of each of the scoring systems. A univariate and multivariate analysis were performed to identify the clinicopathological variables associated with overall survival. RESULTS: The GPS consistently had a higher AUC value at 6 months (0.768), 12 months (0.787), and 24 months (0.758) in comparison with other inflammation-based prognostic scores. A multivariate analysis showed that the GPS was independently associated with overall survival. CONCLUSION: This study demonstrates that the GPS, an inflammation-based prognostic score, is an independent marker of poor prognosis in patients with HCC and is superior to the other inflammation-based prognostic scores in terms of prognostic ability.

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Metadata

Authors
Kinoshita, A., Onoda, H., Imai, N., Iwaku, A., Oishi, M., Fushiya, N., Koike, K., Nishino, H., & Tajiri, H.
Venue
British Journal of Cancer
Published
2012-08-09
Volume
107
Issue
6
Pages
988-993
ISSN
  • 0007-0920 (ISSN-L)
  • 1532-1827
OpenAlex
W1991431093
Cited by
293
References
2
FWCI
6.82
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Comparison of the prognostic value of inflammation-based prognostic scores in patients with hepatocellular carcinoma. https://app.cochat.ai/papers/10.1038/bjc.2012.354
The paper
Kinoshita, A., Onoda, H., Imai, N., Iwaku, A., Oishi, M., Fushiya, N., Koike, K., Nishino, H., & Tajiri, H. (2012). Comparison of the prognostic value of inflammation-based prognostic scores in patients with hepatocellular carcinoma. British Journal of Cancer. https://doi.org/10.1038/bjc.2012.354

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