The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Randomised controlled trials and population-based observational research: partners in the evolution of medical evidence
Open accessAbstract
Recent reports have highlighted the distinct roles and occasional tension between randomised controlled trials (RCTs) and population-based observational research ( Concato, 2012 ; Hershman and Wright, 2012 ; Goodwin et al, 2013 ). In this commentary, we will discuss the relative strengths and limitations of each form of research (see Table 1 ), and propose that well-designed RCTs and population-based observational studies can serve as complementary forms of research to ensure that the results of clinical trials translate into tangible benefits in the general population. Table 1 An overview of relative strengths and limitations of randomized controlled trials and population-based observational studies Full size table
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Cites
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
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Trastuzumab plus Adjuvant Chemotherapy for Operable HER2-Positive Breast Cancer
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Hospital Volume and Surgical Mortality in the United States
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Abiraterone and Increased Survival in Metastatic Prostate Cancer
de Bono, J. S., Logothetis, C. J., Molina, A., Fizazi, K., North, S., Chu, L., Chi, K. N., Jones, R. J., Goodman, O. B., Saad, F., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1014618 · Cited by 4,407 · cited 1×
“…major difference in generalisability between RCTs that report substantial gain and limited toxicity (e.g., abiraterone for advanced prostate cancer (de Bono et al, 2011), adjuvant traztuzumab for breast cancer (Romond et al, 2005)) and RCTs evaluating drugs with marginal effects and substantial…”
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Users' guides to the medical literature
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Receipt of Targeted Therapy and Survival Outcomes in Patients with Metastatic Colorectal Cancer
Koroukian, S. M., Booker, B. D., Vu, L., Schumacher, F. R., Rose, J., Cooper, G. S., Selfridge, J. E., & Markt, S. C. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.50030 · Cited by 27
Temporal relationship of computed and structured diagnoses in electronic health record data
Schulz, W. L., Young, H. P., Coppi, A., Mortazavi, B. J., Lin, Z., Jean, R. A., & Krumholz, H. M. (2021) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-021-01416-x · Cited by 20
Metadata
- Authors
- Booth, C. M., & Tannock, I. F.
- Venue
- British Journal of Cancer
- Published
- 2014-01-14
- Volume
- 110
- Issue
- 3
- Pages
- 551-555
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2055557358
- Cited by
- 469
- References
- 54
- FWCI
- 41.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
