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Use of haploidentical stem cell transplantation continues to increase: the 2015 European Society for Blood and Marrow Transplant activity survey report

Open access
for the European Society for Blood and Marrow Transplantation (EBMT), Passweg, J R, Baldomero, H, Bader, P, Bonini, C, Duarte, R F, Dufour, C, Gennery, A, Kröger, N, Kuball, J, Lanza, F, Montoto, S, Nagler, A, Snowden, J A, Styczynski, J, Mohty, M·2017·Bone Marrow Transplantation

Abstract

Hematopoietic stem cell transplantation (HSCT) is an established procedure for many acquired and congenital disorders of the hematopoietic system. A record number of 42 171 HSCT in 37 626 patients (16 030 allogeneic (43%), 21 596 autologous (57%)) were reported by 655 centers in 48 countries in 2015. Trends include continued growth in transplant activity over the last decade, with the highest percentage increase seen in middle-income countries but the highest absolute growth in the very-high-income countries in Europe. Main indications for HSCT were myeloid malignancies 9413 (25%; 96% allogeneic), lymphoid malignancies 24 304 (67%; 20% allogeneic), solid tumors 1516 (4%; 3% allogeneic) and non-malignant disorders 2208 (6%; 90% allogeneic). Remarkable is the decreasing use of allogeneic HSCT for CLL from 504 patients in 2011 to 255 in 2015, most likely to be due to new drugs. Use of haploidentical donors for allogeneic HSCT continues to grow: 2012 in 2015, a 291% increase since 2005. Growth is seen for all diseases. In AML, haploidentical HSCT increases similarly for patients with advanced disease and for those in CR1. Both marrow and peripheral blood are used as the stem cell source for haploidentical HSCT with higher numbers reported for the latter.

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Metadata

Authors
for the European Society for Blood and Marrow Transplantation (EBMT), Passweg, J. R., Baldomero, H., Bader, P., Bonini, C., Duarte, R. F., Dufour, C., Gennery, A., Kröger, N., Kuball, J., Lanza, F., Montoto, S., Nagler, A., Snowden, J. A., Styczynski, J., & Mohty, M.
Venue
Bone Marrow Transplantation
Published
2017-03-13
Volume
52
Issue
6
Pages
811-817
ISSN
  • 0268-3369 (ISSN-L)
  • 1476-5365
OpenAlex
W2595261904
Cited by
395
References
2
FWCI
38.54
Type
journal article
Language
en
Open access
hybrid

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for the European Society for Blood and Marrow Transplantation (EBMT), Passweg, J. R., Baldomero, H., Bader, P., Bonini, C., Duarte, R. F., Dufour, C., Gennery, A., Kröger, N., Kuball, J., Lanza, F., Montoto, S., Nagler, A., Snowden, J. A., Styczynski, J., & Mohty, M. (2017). Use of haploidentical stem cell transplantation continues to increase: the 2015 European Society for Blood and Marrow Transplant activity survey report. Bone Marrow Transplantation. https://doi.org/10.1038/bmt.2017.34

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.