The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL
Open accessAbstract
Apoptotic cell death is mediated by caspase activation. Autophagy involves the sequestration of cytoplasmic contents into autophagosomes for traffic to lysosomes for degradation. Although autophagy is antiapoptotic, increased numbers of autophagosomes have been associated with forms of non-apoptotic cell death. Apoptosis and autophagy may be co-regulated in the same directions, as the antiapoptotic Bcl-2 and Bcl-xL proteins negatively regulate autophagy by binding to Beclin 1 (mammalian Atg6), and proapoptotic BH3-only proteins may reverse this effect by displacing these interactions. Here, we show that apoptosis can suppress autophagy. Apoptosis induced by the proapoptotic protein Bax reduced autophagy by enhancing caspase-mediated cleavage of Beclin 1 at D149. After cleavage, both N- and C-terminal Beclin 1 fragments change their localisations and these fragments do not interact normally with Vps34, which is required for autophagy. The cleavage of Beclin 1 is a critical event whereby caspases inhibit autophagy, as a non-cleavable Beclin 1 mutant restored autophagy in cells overexpressing Bax.
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Citations
Cites
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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
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Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
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“Endogenous LC3-I levels appear very low in HeLa cells as LC3 antibody has stronger immunoreactivity to LC3-II than LC3 I.(33) (c) GFP-LC3 was co-transfected with increasing levels of Bax plasmid, as indicated in duplicate.”
Cited by
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Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Self-citationGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
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Self-citationThe Beclin 1 network regulates autophagy and apoptosis
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Self-consumption: the interplay of autophagy and apoptosis
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Crosstalk between apoptosis.; necrosis and autophagy
Nikoletopoulou, V., Markaki, M., Palikaras, K., & Tavernarakis, N. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.001 · Cited by 1,366
“The fi nding that the pro-apoptotic protein BAX reduces autophagy by enhancing caspase-mediated cleavage of Beclin 1 at D149 and the fact that non-caspase cleavable Beclin 1, as well as, BCL-X L can rescue BAX-induced autophagy, indicates that apoptosis can suppress autophagy [102].”
Background
Metadata
- Authors
- Luo, S., & Rubinsztein, D. C.
- Venue
- Cell Death & Differentiation
- Published
- 2009-08-28
- Volume
- 17
- Issue
- 2
- Pages
- 268-277
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- OpenAlex
- W2145434871
- Cited by
- 482
- References
- 35
- FWCI
- 17.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Luo, S., & Rubinsztein, D. C. (2010). Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death & Differentiation. https://doi.org/10.1038/cdd.2009.121
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