The DOI matches its Crossref record.
Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Secretion of Serpina3n on astrocyte ApoE lipoprotein may prevent extracellular matrix degradation.
“suggesting that secretion of Serpina3n on astrocyte ApoE lipoprotein may prevent extracellular matrix degradation (92).”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [92]
The Abstract and Discussion report that Serpina3n inhibits granzyme B-mediated cleavage of decorin, an extracellular-matrix proteoglycan, in a murine aortic-aneurysm model. They do not establish that Serpina3n is secreted on astrocyte ApoE lipoproteins or that this mechanism operates in astrocytes; the paper’s ApoE-KO mice are not evidence of lipoprotein carriage. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSerpina3n inhibits granzyme B activity.
“Serpina3n has been reported to inhibit granzyme B activity”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [92]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 43
- Thompson RW . Detection and management of small aortic aneurysms. N Engl J Med 2002; 346: 1484–1486. · DOI
- Ailawadi G, Eliason JL, Upchurch Jr GR . Current concepts in the pathogenesis of abdominal aortic aneurysm. J Vasc Surg 2003; 38: 584–588. · DOI
- Satta J, Laurila A, Paakko P, Haukipuro K, Sormunen R, Parkkila S et al. Chronic inflammation and elastin degradation in abdominal aortic aneurysm disease: an immunohistochemical and electron microscopic study. Eur J Vasc Endovasc Surg 1998; 15: 313–319. · DOI
- Baxter BT, Terrin MC, Dalman RL . Medical management of small abdominal aortic aneurysms. Circulation 2008; 117: 1883–1889. · DOI
- Boivin WA, Cooper DM, Hiebert PR, Granville DJ . Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma. Lab Invest 2009; 89: 1195–1220. · DOI
- Hiebert PR, Boivin WA, Abraham T, Pazooki S, Zhao H, Granville DJ . Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice. Exp Gerontol 2011; 46: 489–499. · DOI
- Chamberlain CM, Ang LS, Boivin WA, Cooper DM, Williams SJ, Zhao H et al. Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm. Am J Pathol 2010; 176: 1038–1049. · DOI
- Danielson KG, Baribault H, Holmes DF, Graham H, Kadler KE, Iozzo RV . Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol 1997; 136: 729–743. · DOI
- Pulkkinen L, Kainulainen K, Krusius T, Makinen P, Schollin J, Gustavsson KH et al. Deficient expression of the gene coding for decorin in a lethal form of Marfan syndrome. J Biol Chem 1990; 265: 17780–17785. · DOI
- Mohamed SA, Sievers HH, Hanke T, Richardt D, Schmidtke C, Charitos EI et al. Pathway analysis of differentially expressed genes in patients with acute aortic dissection. Biomark Insights 2009; 4: 81–90. · DOI
- Horvath AJ, Irving JA, Rossjohn J, Law RH, Bottomley SP, Quinsey NS et al. The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins. J Biol Chem 2005; 280: 43168–43178. · DOI
- Sipione S, Simmen KC, Lord SJ, Motyka B, Ewen C, Shostak I et al. Identification of a novel human granzyme B inhibitor secreted by cultured sertoli cells. J Immunol 2006; 177: 5051–5058. · DOI
- Reed CC, Iozzo RV . The role of decorin in collagen fibrillogenesis and skin homeostasis. Glycoconj J 2002; 19: 249–255. · DOI
- Granville DJ . Granzymes in disease: bench to bedside. Cell Death Differ 2010; 17: 565–566. · DOI
- Hendel A, Hiebert PR, Boivin WA, Williams SJ, Granville DJ . Granzymes in age-related cardiovascular and pulmonary diseases. Cell Death Differ 2010; 17: 596–606. · DOI
- Kurschus FC, Kleinschmidt M, Fellows E, Dornmair K, Rudolph R, Lilie H et al. Killing of target cells by redirected granzyme B in the absence of perforin. FEBS Lett 2004; 562: 87–92. · DOI
- Skjelland M, Michelsen AE, Krohg-Sorensen K, Tennoe B, Dahl A, Bakke S et al. Plasma levels of granzyme B are increased in patients with lipid-rich carotid plaques as determined by echogenicity. Atherosclerosis 2007; 195: e142–e146. · DOI
- Daugherty A, Manning MW, Cassis LA . Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest 2000; 105: 1605–1612. · DOI
- Saraff K, Babamusta F, Cassis LA, Daugherty A . Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2003; 23: 1621–1626. · DOI
- Dayan D, Hiss Y, Hirshberg A, Bubis JJ, Wolman M . Are the polarization colors of picrosirius red-stained collagen determined only by the diameter of the fibers? Histochemistry 1989; 93: 27–29. · DOI
- Sonesson B, Lanne T, Vernersson E, Hansen F . Sex difference in the mechanical properties of the abdominal aorta in human beings. J Vasc Surg 1994; 20: 959–969. · DOI
- Holzapfel GA . Collagen in arterial walls: Biomechanical aspects. In: Fratzl P (ed) Collagen: Structure and Mechanics. Springer: New York, 2008, pp 285–324. · DOI
- Thompson RW, Geraghty PJ, Lee JK . Abdominal aortic aneurysms: basic mechanisms and clinical implications. Curr Probl Surg 2002; 39: 110–230. · DOI
- Whittaker P, Schwab ME, Canham PB . The molecular organization of collagen in saccular aneurysms assessed by polarized light microscopy. Connect Tissue Res 1988; 17: 43–54. · DOI
- Satta J, Juvonen T, Haukipuro K, Juvonen M, Kairaluoma MI . Increased turnover of collagen in abdominal aortic aneurysms, demonstrated by measuring the concentration of the aminoterminal propeptide of type III procollagen in peripheral and aortal blood samples. J Vasc Surg 1995; 22: 155–160. · DOI
- Bode MK, Soini Y, Melkko J, Satta J, Risteli L, Risteli J . Increased amount of type III pN-collagen in human abdominal aortic aneurysms: evidence for impaired type III collagen fibrillogenesis. J Vasc Surg 2000; 32: 1201–1207. · DOI
- Carmo M, Colombo L, Bruno A, Corsi FR, Roncoroni L, Cuttin MS et al. Alteration of elastin, collagen and their cross-links in abdominal aortic aneurysms. Eur J Vasc Endovasc Surg 2002; 23: 543–549. · DOI
- Lindeman JH, Ashcroft BA, Beenakker JW, van Es M, Koekkoek NB, Prins FA et al. Distinct defects in collagen microarchitecture underlie vessel-wall failure in advanced abdominal aneurysms and aneurysms in Marfan syndrome. Proc Natl Acad Sci USA 2010; 107: 862–865. · DOI
- Scott JE . Supramolecular organization of extracellular matrix glycosaminoglycans, in vitro and in the tissues. Faseb J 1992; 6: 2639–2645. · DOI
- Orgel JP, Eid A, Antipova O, Bella J, Scott JE . Decorin core protein (decoron) shape complements collagen fibril surface structure and mediates its binding. PLoS One 2009; 4: e7028. · DOI
- Zhang G, Ezura Y, Chervoneva I, Robinson PS, Beason DP, Carine ET et al. Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development. J Cell Biochem 2006; 98: 1436–1449. · DOI
- Pins GD, Christiansen DL, Patel R, Silver FH . Self-assembly of collagen fibers. Influence of fibrillar alignment and decorin on mechanical properties. Biophys J 1997; 73: 2164–2172. · DOI
- Iwasaki S, Hosaka Y, Iwasaki T, Yamamoto K, Nagayasu A, Ueda H et al. The modulation of collagen fibril assembly and its structure by decorin: an electron microscopic study. Arch Histol Cytol 2008; 71: 37–44. · DOI
- Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA et al. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem J 1994; 302 (Pt 2): 527–534. · DOI
- Penc SF, Pomahac B, Winkler T, Dorschner RA, Eriksson E, Herndon M et al. Dermatan sulfate released after injury is a potent promoter of fibroblast growth factor-2 function. J Biol Chem 1998; 273: 28116–28121. · DOI
- Tufvesson E, Westergren-Thorsson G . Tumour necrosis factor-alpha interacts with biglycan and decorin. FEBS Lett 2002; 530: 124–128. · DOI
- Nili N, Cheema AN, Giordano FJ, Barolet AW, Babaei S, Hickey R et al. Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: potential mechanism for inhibition of intimal hyperplasia after balloon angioplasty. Am J Pathol 2003; 163: 869–878. · DOI
- Pardo J, Wallich R, Ebnet K, Iden S, Zentgraf H, Martin P et al. Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin. Cell Death Differ 2007; 14: 1768–1779. · DOI
- Buzza MS, Zamurs L, Sun J, Bird CH, Smith AI, Trapani JA et al. Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. J Biol Chem 2005; 280: 23549–23558. · DOI
- Choy JC, Hung VH, Hunter AL, Cheung PK, Motyka B, Goping IS et al. Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation. Arterioscler Thromb Vasc Biol 2004; 24: 2245–2250. · DOI
- Theocharis AD, Karamanos NK . Decreased biglycan expression and differential decorin localization in human abdominal aortic aneurysms. Atherosclerosis 2002; 165: 221–230. · DOI
- Abraham T, Carthy J, McManus B . Collagen matrix remodeling in 3-dimensional cellular space resolved using second harmonic generation and multiphoton excitation fluorescence. J Struct Biol 2010; 169: 36–44. · DOI
- Abraham T, Hogg J . Extracellular matrix remodeling of lung alveolar walls in three dimensional space identified using second harmonic generation and multiphoton excitation fluorescence. J Struct Biol 2010; 171: 189–196. · DOI
Cited by
Sorted by citations
McElhaney, J. E., Zhou, X., Talbot, H. K., Soethout, E., Bleackley, R. C., Granville, D. J., & Pawelec, G. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.01.015 · Cited by 229
Self-citationExtracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm
Jana, S., Hu, M., Shen, M., & Kassiri, Z. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0286-3 · Cited by 226
Omura, S., Sato, F., Martinez, N. E., Park, A.-M., Fujita, M., Kennett, N. J., Cvek, U., Minagar, A., Alexander, J. S., & Tsunoda, I. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00516 · Cited by 20
Strickland, M. R., Wang, Z., Golden, L. R., Wang, H., Lu, P., Ren, Y., Tabor, G. T., Zhao, N., Ulrich, J. D., Han, X., et al. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101000 · Cited by 8
Metadata
- Authors
- Ang, L. S., Boivin, W. A., Williams, S. J., Zhao, H., Abraham, T., Carmine-Simmen, K., McManus, B. M., Bleackley, R. C., & Granville, D. J.
- Venue
- Cell Death & Disease
- Published
- 2011-09-08
- Volume
- 2
- Issue
- 9
- Pages
- e209-e209
- ISSN
- 2041-4889
- PMC
- PMC3186906
- Cited by
- 55
- References
- 0
- Language
- en
- Update notices
- erratum (2011-10-13)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review