The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Caspase-1: is IL-1 just the tip of the ICEberg?
Open accessAbstract
Caspase-1, formerly known as interleukin (IL)-1-converting enzyme is best established as the protease responsible for the processing of the key pro-inflammatory cytokine IL-1β from an inactive precursor to an active, secreted molecule. Thus, caspase-1 is regarded as a key mediator of inflammatory processes, and has become synonymous with inflammation. In addition to the processing of IL-1β, caspase-1 also executes a rapid programme of cell death, termed pyroptosis, in macrophages in response to intracellular bacteria. Pyroptosis is also regarded as a host response to remove the niche of the bacteria and to hasten their demise. These processes are generally accepted as the main roles of caspase-1. However, there is also a wealth of literature supporting a direct role for caspase-1 in non-infectious cell death processes. This is true in mammals, but also in non-mammalian vertebrates where caspase-1-dependent processing of IL-1β is absent because of the lack of appropriate caspase-1 cleavage sites. This literature is most prevalent in the brain where caspase-1 may directly regulate neuronal cell death in response to diverse insults. We attempt here to summarise the evidence for caspase-1 as a cell death enzyme and propose that, in addition to the processing of IL-1β, caspase-1 has an important and a conserved role as a cell death protease.
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Cites
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Human ICE/CED-3 Protease Nomenclature
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Cited by
Tilg, H., Moschen, A. R., & Szabo, G. (2016) · Hepatology · doi:10.1002/hep.28456 · Cited by 319
AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3
Denes, A., Coutts, G., Lénárt, N., Cruickshank, S. M., Pelegrin, P., Skinner, J., Rothwell, N., Allan, S. M., & Brough, D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419090112 · Cited by 269
Self-citationAngelova, A. L., Grekova, S. P., Heller, A., Kuhlmann, O., Soyka, E., Giese, T., Aprahamian, M., Bour, G., Rüffer, S., Cziepluch, C., et al. (2014) · Journal of Virology · doi:10.1128/jvi.03688-13 · Cited by 76
Kim, L. A., Amarnani, D., Gnanaguru, G., Tseng, W. A., Vavvas, D. G., & D'Amore, P. A. (2014) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.13-13662 · Cited by 47
NLRP3 inflammasome as therapeutic targets in inflammatory diseases
Prakash, A. V., Park, I.-H., Park, J. W., Bae, J. P., Lee, G. S., & Kang, T. J. (2023) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2023.099 · Cited by 31
Metadata
- Authors
- Denes, A., Lopez-Castejon, G., & Brough, D.
- Venue
- Cell Death & Disease
- Published
- 2012-07-05
- Volume
- 3
- Issue
- 7
- Pages
- e338-e338
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W2152174954
- Cited by
- 265
- References
- 113
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- gold
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