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Cited by 50Autophagy in Disease and TherapyHepatocellular Carcinoma Treatment and PrognosisUbiquitin and proteasome pathways

P300/CBP-associated factor (PCAF) inhibits the growth of hepatocellular carcinoma by promoting cell autophagy

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Jia, Yu-Li, Xu, Meng, Dou, Chang-Wei, Liu, Zhi-Kui, Xue, Yu-Mo, Yao, Bo-Wen, Ding, Ling-Long, Tu, Kang-Sheng +2 more·2016·Cell Death & Disease
DOI 10.1038/cddis.2016.247PMC PMC5133959
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Abstract

Aberrant autophagic processes have been found to have fundamental roles in the pathogenesis of different kinds of tumors, including hepatocellular carcinoma (HCC). P300/CBP-associated factor (PCAF), a histone acetyltransferase (HAT), performs its function by acetylating both histone and non-histone proteins. Our previous studies showed that PCAF was downregulated in HCC tissues and its high expression was significantly associated with patient survival after surgery, serving as a prognostic marker. In this study we found that overexpression of PCAF induced autophagy of HCC cells and its knockdown depressed autophagy. As type II programmed cell death, autophagy induced by PCAF-elicited cell death in HCC cells. In vivo experiments confirmed that PCAF-induced autophagy inhibited tumor growth. Subsequent in vitro experiments showed that PCAF promoted autophagy by inhibiting Akt/mTOR signaling pathway. Our findings show that PCAF is a novel modulator of autophagy in HCC, and can serve as an attractive therapeutic strategy of HCC treatment.

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  • Notable perturbation-specific gene ontology terms include ribosome assembly (SETD5), mitochondrion organization (FOXP1), lipid homoeostasis (IRF2BPL), autophagosome maturation (KAT2B), and cilium development (MECP2).

    “Some notable examples include the gene ontology terms ribosome assembly (SETD5 perturbation)36, mitochondrion organization (FOXP1 perturbation)37, lipid homoeostasis (IRF2BPL perturbation)38, autophagosome maturation (KAT2B perturbation)39 and cilium development (MECP2 perturbation)40.”

    From Single-cell brain organoid screening identifies developmental defects in autism (2023) · cites this paper as [39]

    Citation 39 is attached to the KAT2B–autophagosome maturation example. The Results section reports that perturbing PCAF affects autophagy and autophagosome formation in hepatocellular carcinoma cells, but it does not identify autophagosome maturation as a perturbation-specific gene ontology term or establish an effect specifically on maturation. (LLM, conf=0.85)

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Research works printed but not linked: 36

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Cited by

Sorted by citations

Authors
Jia, Y.-L., Xu, M., Dou, C.-W., Liu, Z.-K., Xue, Y.-M., Yao, B.-W., Ding, L.-L., Tu, K.-S., Zheng, X., & Liu, Q.-G.
Affiliations
First Affiliated Hospital of Xi'an Jiaotong University (CN)
Corresponding author
Zheng, Xin
ORCID
Venue
Cell Death & Disease
Publisher
Springer Science and Business Media LLC
Published
2016-10-06
Volume
7
Issue
10
Pages
e2400-e2400
ISSN
2041-4889 (ISSN-L)
DOI
10.1038/cddis.2016.247
PMC
PMC5133959
OpenAlex
W2529330887
Cited by
50
References
1
Citations by year
2026: 4 · 2025: 8 · 2024: 6 · 2023: 5 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 8 · 2017: 3
FWCI
4.99
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Death and Disease (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords
PCAF, histone acetyltransferase, hepatocellular carcinoma, autophagy, tumor growth inhibition, Akt/mTOR signaling, prognostic factors, histone acetylation
MeSH terms
p300-CBP-Associated Factor, Adenine, Animals, Autophagy, Female, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Mice, Inbred BALB C, Mice, Nude, Oligopeptides, Signal Transduction, Apoptosis, Macrolides, Xenograft Model Antitumor Assays, Cell Line, Tumor, Cell Proliferation, p300-CBP Transcription Factors, Proto-Oncogene Proteins c-akt, Gene Knockdown Techniques, TOR Serine-Threonine Kinases

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