The DOI matches its Crossref record.
Age and morphine analgesia in cancer patients with postoperative pain
Abstract
Our objective was to identify age-related differences in analgesia after 8 and 16 mg morphine intramuscularly. Retrospective analyses of controlled relative analgesic potency assays in 947 postoperative cancer patients revealed differences among age groups (18 to 29, 30 to 49, 50 to 69, and 70 to 89 yr) in total pain relief and duration of relief with little differences in peak relief. Weight and initial pain intensity were in the same range among age and dose groups. Aging was associated with enhanced analgesia. The difference in total relief between the extremes of adult age was approximately twice that with twice the dose. While in 50% of the oldest group relief was no longer obtained at 5 hr, in 50% of the youngest group relief was no longer obtained at 3 hr. These observations suggest that age is a factor in morphine analgesia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Predictors of Postoperative Pain and Analgesic Consumption: A Qualitative Systematic Review
Ip, H. Y. V., Abrishami, A., Peng, P. W. H., Wong, J., & Chung, F. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181aae87a · Cited by 1,055
Pergolizzi, J., Böger, R. H., Budd, K., Dahan, A., Erdine, S., Hans, G., Kress, H., Langford, R., Likar, R., Raffa, R. B., et al. (2008) · Pain Practice · doi:10.1111/j.1533-2500.2008.00204.x · Cited by 854
Clinical Pharmacokinetics of Fentanyl and its Newer Derivatives
Mather, L. E. (1983) · Clinical Pharmacokinetics · doi:10.2165/00003088-198308050-00004 · Cited by 393
Management of drug therapy in the elderly
Desforges, J. F., Montamat, S. C., Cusack, B. J., & Vestal, R. E. (1989) · New England Journal of Medicine · doi:10.1056/nejm198908033210507 · Cited by 388
Desbiens, N. A., Wu, A. W., Broste, S. K., Wenger, N. S., Connors, A. F., Lynn, J., Yasui, Y., Phillips, R. S., & Fulkerson, W. (1996) · Critical Care Medicine · doi:10.1097/00003246-199612000-00005 · Cited by 353
Metadata
- Authors
- Kaiko, R. F.
- Venue
- Clinical Pharmacology and Therapeutics
- Publisher
- Wiley
- Published
- 1980-12
- Volume
- 28
- Issue
- 6
- Pages
- 823-826
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2095574179
- Cited by
- 188
- References
- 0
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Age and morphine analgesia in cancer patients with postoperative pain. https://app.cochat.ai/papers/10.1038/clpt.1980.241
- The paper
- Kaiko, R. F. (1980). Age and morphine analgesia in cancer patients with postoperative pain. Clinical Pharmacology and Therapeutics. https://doi.org/10.1038/clpt.1980.241
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
