How a cigarette is smoked determines blood nicotine levels
Abstract
Indirect evidence suggests that smoking low-tar and nicotine cigarettes does not necessarily reduce exposure to these substances. Puff volume, duration and number, interpuff interval, and volume and duration of inhalation were measured while 11 subjects smoked two or four tobacco cigarettes. Nicotine blood levels and breath CO were measured before and after smoking. The machine-determined nicotine yields of the cigarettes correlated (r = 0.52) with the increase in nicotine blood levels after smoking but, when individual differences in smoking behavior were taken into account along with the nicotine yield, there was a stronger correlation with nicotine blood levels (r = 0.84 to 0.93).
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Salivary nicotine concentrations of 1 μM have been reported.
“salivary nicotine concentrations of 1 gM (25)”
From Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro. (1986) · cites this paper as [25]
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Signs and Symptoms of Tobacco Withdrawal
Hughes, J. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800030107013 · Cited by 1,669 · see citing works
Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro.
Barbieri, R. L., Gochberg, J., & Ryan, K. J. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112494 · Cited by 197 · see citing works
Slawecki, C. J., Thorsell, A. K., Khoury, A. E., Mathé, A. A., & Ehlers, C. L. (2005) · Neuropeptides · doi:10.1016/j.npep.2005.06.002 · Cited by 64 · see citing works
- Authors
- Herning, R. I., Jones, R. T., Benowitz, N. L., & Mines, A. H.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Herning, Ronald I
- ORCID
- Benowitz, Neal L
- Venue
- Clinical Pharmacology and Therapeutics
- Publisher
- Wiley
- Published
- 1983-01
- Volume
- 33
- Issue
- 1
- Pages
- 84-90
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2168368029
- Cited by
- 185
- References
- 0
- Citations by year
- 2024: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 4
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- nicotine yield, low-tar cigarettes, low-nicotine cigarettes, puff volume, puff duration, inhalation volume, carbon monoxide, tobacco smoke exposure
- MeSH terms
- Breath Tests, Carbon Monoxide, Female, Humans, Male, Nicotine, Smoking
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