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Age-related morphine kinetics
Abstract
The kinetic disposition of morphine was compared in 13 young and 7 older healthy subjects after a single intravenous dose of 10 mg/70 kg morphine. The apparent volume of distribution at steady state in elderly subjects was only half of that in young subjects. This difference was derived from reductions in both central and peripheral kinetic compartment volumes in the older subjects. The beta elimination phase for morphine was more rapid, but its plasma clearance was reduced in older subjects. Calculation of the peripheral compartment morphine concentration for these subjects indicated that drug concentration in this kinetic space was higher in older subjects for 1.5 hr after dosing.
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Citations
Cited by
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Poulin, P., & Theil, F. (2002) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10005 · Cited by 568
Management of drug therapy in the elderly
Desforges, J. F., Montamat, S. C., Cusack, B. J., & Vestal, R. E. (1989) · New England Journal of Medicine · doi:10.1056/nejm198908033210507 · Cited by 388
Desbiens, N. A., Wu, A. W., Broste, S. K., Wenger, N. S., Connors, A. F., Lynn, J., Yasui, Y., Phillips, R. S., & Fulkerson, W. (1996) · Critical Care Medicine · doi:10.1097/00003246-199612000-00005 · Cited by 353
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Macintyre, P. E., & Jarvis, D. A. (1996) · Pain · doi:10.1016/0304-3959(95)00128-x · Cited by 305
Metadata
- Authors
- Owen, J. A., Sitar, D. S., Berger, L., Brownell, L., Duke, P. C., & Mitenko, P. A.
- Venue
- Clinical Pharmacology and Therapeutics
- Publisher
- Wiley
- Published
- 1983-09
- Volume
- 34
- Issue
- 3
- Pages
- 364-368
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2112249040
- Cited by
- 173
- References
- 0
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Age-related morphine kinetics. https://app.cochat.ai/papers/10.1038/clpt.1983.180
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- Owen, J. A., Sitar, D. S., Berger, L., Brownell, L., Duke, P. C., & Mitenko, P. A. (1983). Age-related morphine kinetics. Clinical Pharmacology and Therapeutics. https://doi.org/10.1038/clpt.1983.180
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
