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Cited by 128Antifungal resistance and susceptibilityPharmaceutical studies and practicesAntibiotics Pharmacokinetics and Efficacy

The DOI matches its Crossref record.

Pharmacokinetics of fluconazole in very low birth weight infants during the first two weeks of life

Saxén, Harri, Hoppu, Kalle, Pohjavuori, Maija·1993·Clinical Pharmacology and Therapeutics
DOI 10.1038/clpt.1993.147
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Abstract

OBJECTIVE: To find a dose of fluconazole for very low birth weight infants during an outbreak of Candida parapsilosis. METHODS: Twelve premature infants (mean gestational age, 27.4 weeks; mean birth weight, 912 gm) receiving fluconazole prophylactically from the first day of life were enrolled in an open phase I-II pharmacokinetics, safety, and tolerance trial. Up to 5 doses of 6 mg/kg were administered intravenously every 72 hours during the first 2 weeks of life. Pharmacokinetic characteristics of fluconazole were determined after the first, third, and fifth doses. RESULTS: The mean peak and trough concentrations after the 3 doses were 5.5 and 2.6 micrograms/ml, 12.8 and 4.3 micrograms/ml, and 10.0 and 2.9 micrograms/ml (p = 0.0002 and p = 0.07), respectively. The mean fluconazole half-lives were 88.6 hours (n = 7), 67.5 hours (n = 9), and 55.2 hours (n = 4; p = 0.3). The mean total clearance corrected for weight (CL/kg) was 0.18 ml/min/kg (n = 7), 0.33 ml/min/kg (n = 7), and 0.52 ml/min/kg (n = 4; p = 0.02), and the mean volume of distribution 1.18 L/kg (n = 7), 1.84 L/kg (n = 7), and 2.25 L/kg (n = 4; p = 0.05). Weight-corrected clearance increased with postnatal age (r = 0.61; p = 0.007). CONCLUSIONS: With the used fluconazole dose (6 mg/kg every 3 days), the mean serum peak and trough concentrations increased during the first week but decreased during the second week. After the first week we suggest a dose of 6 mg/kg every 2 days, or even daily.

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Metadata

Authors
Saxén, H., Hoppu, K., & Pohjavuori, M.
Affiliations
University of Helsinki (FI)
Corresponding author
Hoppu, Kalle
ORCID
Hoppu, Kalle
Venue
Clinical Pharmacology and Therapeutics
Publisher
Wiley
Published
1993
Volume
54
Issue
3
Pages
269-277
ISSN
  • 0009-9236 (ISSN-L)
  • 1532-6535
DOI
10.1038/clpt.1993.147
OpenAlex
W1969659982
Cited by
127
References
0
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 6 · 2012: 4
FWCI
2.72
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
Keywords
fluconazole, pharmacokinetics, very low birth weight infants, preterm infants, Candida parapsilosis, antifungal prophylaxis, intravenous administration, drug clearance, volume of distribution, half-life, postnatal age
MeSH terms
Candidiasis, Female, Half-Life, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Male, Pilot Projects, Fluconazole

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