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Cited by 414

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Operational Implementation of Prospective Genotyping for Personalized Medicine: The Design of the Vanderbilt PREDICT Project

Open access
Pulley, J M, Denny, J C, Peterson, J F, Bernard, G R, Vnencak-Jones, C L, Ramirez, A H, Delaney, J T, Bowton, E, Brothers, K, Johnson, K, Crawford, D C, Schildcrout, J, Masys, D R, Dilks, H H, Wilke, R A, Clayton, E W, Shultz, E, Laposata, M, McPherson, J, Jirjis, J N, Roden, D M·2012·Clinical Pharmacology & Therapeutics
DOI 10.1038/clpt.2011.371
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Abstract

The promise of "personalized medicine" guided by an understanding of each individual's genome has been fostered by increasingly powerful and economical methods to acquire clinically relevant information. We describe the operational implementation of prospective genotyping linked to an advanced clinical decision-support system to guide individualized health care in a large academic health center. This approach to personalized medicine entails engagement between patient and health-care provider, identification of relevant genetic variations for implementation, assay reliability, point-of-care decision support, and necessary institutional investments. In one year, approximately 3,000 patients, most of whom were scheduled for cardiac catheterization, were genotyped on a multiplexed platform that included genotyping for CYP2C19 variants that modulate response to the widely used antiplatelet drug clopidogrel. These data are deposited into the electronic medical record (EMR), and point-of-care decision support is deployed when clopidogrel is prescribed for those with variant genotypes. The establishment of programs such as this is a first step toward implementing and evaluating strategies for personalized medicine.

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Registry

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Metadata

Authors
Pulley, J. M., Denny, J. C., Peterson, J. F., Bernard, G. R., Vnencak-Jones, C. L., Ramirez, A. H., Delaney, J. T., Bowton, E., Brothers, K., Johnson, K., Crawford, D. C., Schildcrout, J., Masys, D. R., Dilks, H. H., Wilke, R. A., Clayton, E. W., Shultz, E., Laposata, M., McPherson, J., Jirjis, J. N., & Roden, D. M.
Venue
Clinical Pharmacology & Therapeutics
Publisher
Wiley
Published
2012-05-16
Volume
92
Issue
1
Pages
87-95
ISSN
  • 0009-9236 (ISSN-L)
  • 1532-6535
DOI
10.1038/clpt.2011.371
OpenAlex
W2050697524
Cited by
414
References
37
FWCI
52.77
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Operational Implementation of Prospective Genotyping for Personalized Medicine: The Design of the Vanderbilt PREDICT Project. https://app.cochat.ai/papers/10.1038/clpt.2011.371
The paper
Pulley, J. M., Denny, J. C., Peterson, J. F., Bernard, G. R., Vnencak-Jones, C. L., Ramirez, A. H., Delaney, J. T., Bowton, E., Brothers, K., Johnson, K., Crawford, D. C., Schildcrout, J., Masys, D. R., Dilks, H. H., Wilke, R. A., Clayton, E. W., Shultz, E., Laposata, M., McPherson, J., . . . Roden, D. M. (2012). Operational Implementation of Prospective Genotyping for Personalized Medicine: The Design of the Vanderbilt PREDICT Project. Clinical Pharmacology & Therapeutics. https://doi.org/10.1038/clpt.2011.371

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.