Highlights from the International Transporter Consortium Second Workshop
Abstract
The Second International Transporter Consortium (ITC) Workshop was held with the purpose of expanding on previous white-paper recommendations, discussing recent regulatory draft guidance documents on transporter-drug interactions, and highlighting transporter-related challenges in drug development. Specific goals were to discuss additional clinically relevant transporters (MATEs, MRP2, BSEP) and best-practice methodologies and to re-evaluate ITC decision trees based on actual case studies. The outcome of the workshop will be a series of white papers targeted for publication in 2013.
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The protein expression of transporters important for drug influx and efflux in the liver is relatively stable throughout the 168-h culture.
“the protein expression of the transporters identified as being important for drug influx and efflux in the liver (Zamek-Gliszczynski et al. 2012) is relatively stable throughout the 168-h culture.”
From Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile (2017) · cites this paper as Zamek-Gliszczynski et al. 2012
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Heslop, J. A., Rowe, C., Walsh, J., Sison-Young, R., Jenkins, R., Kamalian, L., Kia, R., Hay, D., Jones, R. P., Malik, H. Z., et al. (2017) · Archives of Toxicology · doi:10.1007/s00204-016-1694-y · Cited by 141 · see citing works
- Authors
- Zamek-Gliszczynski, M. J., Hoffmaster, K. A., Tweedie, D. J., Giacomini, K. M., & Hillgren, K. M.
- Affiliations
- Boehringer Ingelheim (United States) (US)
- University of California, San Francisco (US)
- Eli Lilly (United States) (US)
- ORCID
- Giacomini, K M
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2012-11
- Volume
- 92
- Issue
- 5
- Pages
- 553-556
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2085134666
- Cited by
- 82
- References
- 0
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 7 · 2016: 12 · 2015: 11 · 2014: 14 · 2013: 18 · 2012: 1
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- drug transporters, mate, MRP2, bile salt export pump, drug development challenges, regulatory guidelines
- MeSH terms
- Cooperative Behavior, Decision Trees, Drug Interactions, Pharmaceutical Preparations, Humans, Drug Design, Membrane Transport Proteins, Internationality
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