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Cited by 366Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and MetabolismNuclear Receptors and Signaling

PPARs: diverse regulators in energy metabolism and metabolic diseases

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Wang, Yong-Xu·2010·Cell Research
DOI 10.1038/cr.2010.13PMC PMC4084607
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Abstract

The nuclear receptor PPARs are fundamentally important for energy homeostasis. Through their distinct yet overlapping functions and tissue distribution, the PPARs regulate many aspects of energy metabolism at the transcriptional level. Functional impairment or dysregulation of these receptors leads to a variety of metabolic diseases, while their ligands offer many metabolic benefits. Studies of these receptors have advanced our knowledge of the transcriptional basis of energy metabolism and helped us understand the pathogenic mechanisms of metabolic syndrome.

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References 117 · Cited by 366

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Authors
Wang, Y.-X.
Affiliations
University of Massachusetts Chan Medical School (US)
Corresponding author
Wang, Yong-Xu
ORCID
Wang, Yong-Xu
Venue
Cell Research
Publisher
Springer Science and Business Media LLC
Published
2010-01-26
Volume
20
Issue
2
Pages
124-137
ISSN
  • 1001-0602 (ISSN-L)
  • 1748-7838
DOI
10.1038/cr.2010.13
PMC
PMC4084607
OpenAlex
W2126218858
Cited by
366
References
117
Citations by year
2026: 25 · 2025: 23 · 2024: 31 · 2023: 24 · 2022: 35 · 2021: 30 · 2020: 32 · 2019: 24 · 2018: 23 · 2017: 14 · 2016: 20 · 2015: 18 · 2014: 13 · 2013: 17 · 2012: 23
FWCI
1.52
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Cell Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders
  • American Diabetes Association
  • Richard and Susan Smith Family Foundation
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (R56DK076118, R01DK076118)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
peroxisome proliferator-activated receptors, energy metabolism, energy homeostasis, metabolic disorders, metabolic syndrome, transcriptional regulation, PPAR ligands, nuclear receptors
MeSH terms
Animals, Energy Metabolism, Humans, Insulin Resistance, Metabolic Diseases, Models, Biological, Thiazolidinediones, Peroxisome Proliferator-Activated Receptors, Adipogenesis

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