Structural studies of NF-κB signaling
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NF-κBs are a family of transcription factors that control a number of essential cellular functions including immune responses, cell proliferation and antiapoptosis. NF-κB activities are tightly regulated through upstream signaling molecules and downstream feedback loops. In this review, structural discoveries in the NF-κB pathway are presented. With the structure information, the following questions may be addressed: (1) How do NF-κBs activate their target genes? (2) How do IκBs inhibit NF-κB activities in the steady state? (3) How do upstream signaling molecules activate the NF-κB pathway? and (4) How do the feedback loops shut down the NF-κB pathway to avoid constitutive NF-κB activation?
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Microglial NFκB is sequestered in the cytoplasm by inhibitor of κB (IκB).
“Microglial NFκB is a dimer of p50 (NFκB1) and p65 (Rel-A) [138,139] and is sequestered in the cytoplasm by inhibitor of κB (IκB).”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [139]
NFκB is a master transcription factor controlling pro-inflammatory gene expression in microglia.
“Nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) is a master transcription factor controlling pro-inflammatory gene expression in microglia.”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [139]
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References 97 · Cited by 134
- Authors
- Zheng, C., Yin, Q., & Wu, H.
- Affiliations
- Weill Cornell Medicine (US)
- Corresponding author
- Wu, Hao
- Venue
- Cell Research
- Published
- 2010-12-07
- Volume
- 21
- Issue
- 1
- Pages
- 183-195
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC3044936
- OpenAlex
- W2006699608
- Cited by
- 134
- References
- 97
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 7 · 2023: 11 · 2022: 7 · 2021: 13 · 2020: 8 · 2019: 11 · 2018: 9 · 2017: 12 · 2016: 8 · 2015: 8 · 2014: 7 · 2013: 4 · 2012: 14
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R37AI050872, AI050872, AI045937, R01AI050872, AI079260, R01AI079260, R01AI045937)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- NF-κB signaling, transcription factors, NF-κB activation, feedback loops, gene expression regulation, protein structure, immune response, apoptosis
- MeSH terms
- DNA, Humans, Protein Binding, Signal Transduction, NF-kappa B, Protein Structure, Tertiary, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins, I-kappa B Kinase
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