Cell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells
Open accessAbstract
Stimulated by the 2012 Nobel Prize in Physiology or Medicine awarded for Shinya Yamanaka and Sir John Gurdon, there is an increasing interest in the induced pluripotent stem (iPS) cells and reprograming technologies in medical science. While iPS cells are expected to open a new era providing enormous opportunities in biomedical sciences in terms of cell therapies and regenerative medicine, safety-related concerns for iPS cell-based cell therapy should be resolved prior to the clinical application of iPS cells. In this review, the pre-clinical investigations of cell therapy for spinal cord injury (SCI) using neural stem/progenitor cells derived from iPS cells, and their safety issues in vivo, are outlined. We also wish to discuss the strategy for the first human trails of iPS cell-based cell therapy for SCI patients.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a mouse spinal cord injury model, transplanting neural stem/progenitor cells made from human iPSCs was reported to promote ongoing motor recovery.
“Similarly, transplantation of neural stem or progenitor cells derived from human induced pluripotent stem cells (iPSCs) in a mouse of model of spinal cord injury was reported to stimulate continual motor function recovery148,149.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [149]
The citation lists haven’t been fetched yet
References 52 · Cited by 214
- Authors
- Nakamura, M., & Okano, H.
- Affiliations
- Keio University (JP)
- Corresponding author
- Okano, Hideyuki
- Venue
- Cell Research
- Published
- 2012-12-11
- Volume
- 23
- Issue
- 1
- Pages
- 70-80
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC3541652
- OpenAlex
- W2034271168
- Cited by
- 214
- References
- 52
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 13 · 2023: 13 · 2022: 17 · 2021: 15 · 2020: 17 · 2019: 13 · 2018: 16 · 2017: 23 · 2016: 18 · 2015: 15 · 2014: 28 · 2013: 9
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- California Institute for Regenerative Medicine
- Keio University
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- spinal cord injury, induced pluripotent stem cells, cell transplantation, neural stem/progenitor cells, cell therapy safety, reprogramming, regenerative medicine, clinical trials
- MeSH terms
- Animals, Cell Differentiation, Humans, Spinal Cord Injuries, Regenerative Medicine, Induced Pluripotent Stem Cells, Neural Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
