Mechanisms of apoptotic phosphatidylserine exposure
Open accessAbstract
It has been a long-standing enigma which scramblase causes phosphatidylserine residues to be exposed on the surface of apoptotic cells, thereby facilitating the phagocytic recognition, engulfment and destruction of apoptotic corpses. In a recent paper in Science, Nagata and coworkers reveal that the scramblases Xkr8 and its C. elegans ortholog, CED-8, are activated by caspase cleavage in apoptotic cells.
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Phosphatidylserine and phosphatidylethanolamine are known to play important roles in macrophage mobility, phagocytosis, and apoptosis.
“these lipid subspecies are known to play important roles in Mθ mobility, phagocytosis, and apoptosis (Greenberg et al., 2006; Marino and Kroemer, 2013; Shiratsuchi et al., 1998).”
From Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis (2017) · cites this paper as Marino and Kroemer, 2013
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Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis
Price, N. L., Rotllan, N., Canfrán-Duque, A., Zhang, X., Pati, P., Arias, N., Moen, J., Mayr, M., Ford, D. A., Baldán, Á., et al. (2017) · Cell reports · doi:10.1016/j.celrep.2017.10.023 · Cited by 129 · see citing works
- Authors
- Mariño, G., & Kroemer, G.
- Affiliations
- Inserm (FR)
- Corresponding author
- Kroemer, Guido
- Venue
- Cell Research
- Published
- 2013-08-27
- Volume
- 23
- Issue
- 11
- Pages
- 1247-1248
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC3817543
- OpenAlex
- W2079399167
- Cited by
- 194
- References
- 0
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 19 · 2023: 16 · 2022: 30 · 2021: 23 · 2020: 24 · 2019: 19 · 2018: 12 · 2017: 10 · 2016: 11 · 2015: 3 · 2014: 5
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- phospholipid scramblase, caspase cleavage, efferocytosis, phagocytosis, Caenorhabditis elegans
- MeSH terms
- Animals, Calcium, Cell Membrane, Humans, Phospholipids, Phospholipid Transfer Proteins
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