ROS sets the stage for macrophage differentiation
Open accessAbstract
While M1 macrophages are highly pro-inflammatory and microbicidal, M2 macrophages and the related tumor associated macrophages (TAMs) regulate tissue remodeling and angiogenesis and can display immunomodulatory activity. In July issue of Cell Research, Zhang et al. show that ROS production, critical for the activation and functions of M1 macrophages, is necessary for the differentiation of M2 macrophages and TAMs, and that antioxidant therapy blocks TAM differentiation and tumorigenesis in mouse models of cancer.
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Activated macrophages can produce large amounts of ROS, and ROS production is higher in M1 macrophages compared to M2 macrophages.
“Activated macrophages can produce large amounts of ROS. ROS production are higher in M1 macrophages compared to in M2 macrophages [39].”
From Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway (2020) · cites this paper as [39]
The discussion paragraph beginning “Collectively” says ROS production is usually associated with M1 rather than M2 activation and identifies ROS production as important to M1 antimicrobial activity. The Figure 1 caption also says ROS production increases during macrophage differentiation. Neither passage establishes that activated macrophages produce “large amounts” of ROS or directly compares ROS production levels in M1 and M2 macrophages; page numbers are unavailable in our copy. (LLM, conf=0.84)
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References 10 · Cited by 150
Research works printed but not linked: 10
- [1]1. Rakoff-Nahoum S, Medzhitov R. Nat Rev Cancer 2009; 9:57-63.
- [2]2. Gordon S, Taylor PR. Nat Rev Immunol 2005; 5:953-964.
- [3]3. Allavena P, Mantovani A. Clin Exp Immunol 2012; 167:195-205.
- [4]4. Zhang Y, Choksi S, Chen K, et al. Cell Res 2013; 23:898-914.
- [5]5. Sardina JL, Lopez-Ruano G, Sanchez- Abarca LI, et al. Cell Death Differ 2010; 17:1842-1854.
- [6]6. Storz P. Front Biosci 2005; 10:1881-1896.
- [7]7. Reuter S, Gupta SC, Chaturvedi MM, et al. Free Radic Biol Med 2010; 49:1603-1616.
- [8]8. O'Neill LA, Hardie DG. Nature 2013; 493:346-355.
- [9]9. Grivennikov SI, Greten FR, Karin M. Cell 2010; 140:883-899.
- [10]10. Finkel T. J Cell Biol 2011; 194:7-15.
- Authors
- Covarrubias, A., Byles, V., & Horng, T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Horng, Tiffany
- Venue
- Cell Research
- Published
- 2013-07-09
- Volume
- 23
- Issue
- 8
- Pages
- 984-985
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC3731567
- OpenAlex
- W2006328613
- Cited by
- 150
- References
- 10
- Citations by year
- 2026: 17 · 2025: 21 · 2024: 31 · 2023: 22 · 2022: 16 · 2021: 5 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 2 · 2014: 2
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI102964)
- National Institute of Environmental Health Sciences (T32ES016645)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- reactive oxygen species, macrophage differentiation, M2 macrophages, tumor-associated macrophages, M1 macrophages, antioxidant therapy, carcinogenesis, immunomodulation, angiogenesis, tissue remodeling
- MeSH terms
- Animals, Female, Humans, Macrophages, Reactive Oxygen Species
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