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The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells
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HIF-dependent metabolic reprogramming and redox dysregulation exacerbate ER stress, linking hypoxic signaling to UPR activation, particularly through the IRE1α-XBP1 axis.
“Moreover, HIF dependent metabolic reprogramming and redox dysregulation exacerbate endoplasmic reticulum (ER) stress, linking hypoxic signaling to activation of the unfolded protein response (UPR), particularly through the IRE1α–XBP1 axis [[241], [242], [243], [244]].”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [243]
The Dear Editor section describes IRE1α–XBP1 as a branch of the UPR and reports increased Xbp1 splicing and ER-stress markers in pancreatic islets under high-fat-diet-induced metabolic stress (page not specified). It does not link that response to HIF, hypoxic signaling, metabolic reprogramming, or redox dysregulation. (LLM, conf=0.86)
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References 16 · Cited by 60
Research works printed but not linked: 15
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Metadata
- Authors
- Xu, T., Yang, L., Yan, C., Wang, X., Huang, P., Zhao, F., Zhao, L., Zhang, M., Jia, W., Wang, X., & Liu, Y.
- Affiliations
- Shandong University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Wang, Xiaoxia
- Wang, Xiangdong
- Liu, Yong
- Venue
- Cell Research
- Published
- 2014-05-06
- Volume
- 24
- Issue
- 9
- Pages
- 1137-1140
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC4152740
- OpenAlex
- W2034792944
- Cited by
- 60
- References
- 16
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 4 · 2018: 8 · 2017: 8 · 2016: 2 · 2015: 4 · 2014: 1
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (973 Program, 81321062, 31230036, 2012CB524900, 81170814, 91213306)
- Ministry of Education of the People's Republic of China
- Chinese Academy of Sciences
- National Key Research and Development Program of China (2011CB910900, 2012CB524900)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- IRE1α, XBP1, unfolded protein response, endoplasmic reticulum stress, pancreatic beta cells, metabolic stress, glucose-stimulated insulin secretion, insulin secretion, pancreatic islets, diabetes mellitus, hypothalamus
- MeSH terms
- Regulatory Factor X Transcription Factors, X-Box Binding Protein 1, Animals, DNA-Binding Proteins, Endoribonucleases, Glucose, Homeostasis, Stress, Physiological, Transcription Factors, Signal Transduction, Protein Serine-Threonine Kinases, Cell Proliferation, Insulin-Secreting Cells, Mice, Diet, High-Fat
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