Genome-wide identification of CRISPR/Cas9 off-targets in human genome
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Other publications observed a much lower validation rate for dCas9 ChIP-Seq.
“However, other publications observed a much lower validation rate (Cencic et al., 2014; Duan et al., 2014; Tsai et al., 2015).”
From Off-target effects in CRISPR/Cas9 gene editing (2023) · cites this paper as Duan et al., 2014
Cas9 could associate with genomic loci without exerting its nuclease function, which is a major caveat in Cas9 ChIP-Seq-based off-target detection assays.
“These studies indicated that Cas9 could associate with genomic loci without exerting its nuclease function, deposing a major caveat in Cas9 ChIP-Seq-based off-target detection assay.”
From Off-target effects in CRISPR/Cas9 gene editing (2023) · cites this paper as Duan et al., 2014
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References 15 · Cited by 137
- Authors
- Duan, J., Lu, G., Xie, Z., Lou, M., Luo, J., Guo, L., & Zhang, Y.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Institute of Biological Sciences, Beijing (CN)
- Corresponding author
- Zhang, Yu
- Venue
- Cell Research
- Published
- 2014-07-01
- Volume
- 24
- Issue
- 8
- Pages
- 1009-1012
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC4123298
- OpenAlex
- W2020138382
- Cited by
- 137
- References
- 15
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 17 · 2021: 11 · 2020: 13 · 2019: 13 · 2018: 16 · 2017: 14 · 2016: 10 · 2015: 15 · 2014: 9
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Directorate for Biological Sciences
- Thousand Young Talents Program of China
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- CRISPR/Cas9, off-target binding, off-target cleavage, crRNA, PAM, seed sequence, genome-wide identification, human genome, genome editing specificity, homing endonucleases, zinc finger nucleases, TALEN
- MeSH terms
- Empty Spiracles Homeobox Proteins, Humans, Recombinant Fusion Proteins, RNA, Transcription Factors, Genome, Human, Protein Structure, Tertiary, Homeodomain Proteins, HEK293 Cells, CRISPR-Associated Proteins
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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