Presenting mitochondrial antigens: PINK1, Parkin and MDVs steal the show
Open accessAbstract
In a recent paper published in Cell, Matheoud et al. demonstrated that, in response to cellular stress, self-antigens can be extracted from mitochondria via mitochondrial-derived vesicles and presented at the cell surface to trigger an immune response; this pathway, termed mitochondrial antigen presentation (MitAP), is repressed by PINK1 and Parkin. These findings implicate autoimmune mechanisms in Parkinson's disease.
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References 10 · Cited by 30
Research works printed but not linked: 10
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- Authors
- Roberts, R. F., & Fon, E. A.
- Affiliations
- Montreal Neurological Institute and Hospital (CA)
- Corresponding author
- Fon, Edward A
- Venue
- Cell Research
- Published
- 2016-09-02
- Volume
- 26
- Issue
- 11
- Pages
- 1180-1181
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC5099861
- OpenAlex
- W2507170775
- Cited by
- 30
- References
- 10
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 8 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 2
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- mitochondrial-derived vesicles, PINK1, Parkin, autoantigen presentation, cellular stress, autoimmunity, Parkinson's disease, mitochondrial stress response
- MeSH terms
- Humans, Mitochondria, Parkinson Disease, Protein Kinases, Antigen Presentation, Ubiquitin-Protein Ligases
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