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Cited by 97Liver physiology and pathologyImmune cells in cancerDrug-Induced Hepatotoxicity and Protection

Infiltrating monocytes in liver injury and repair

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Brempelis, Katherine J, Crispe, Ian N·2016·Clinical & Translational Immunology
DOI 10.1038/cti.2016.62PMC PMC5133365
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Abstract

Noninfectious liver injury causes many acute and chronic liver diseases around the globe, and particularly in developed nations. Bone marrow‐derived monocytes infiltrate the damaged liver tissue and are a critical component of the innate immune response that may drive injury resolution or host death in the short term or chronic inflammation, fibrosis and hepatocellular carcinoma in the long term. Monocytes often play dual roles in liver injury—both perpetuating inflammation and promoting resolution of inflammation and fibrosis. Thus, we will address the role that monocytes play in different experimental forms of noninfectious liver injury; considering in particular the importance of the transition from inflammatory Ly6Chi monocytes to pro‐resolution Ly6Clo monocyte‐derived macrophages and the consequences of this transition for disease progression and resolution.

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Authors
Brempelis, K. J., & Crispe, I. N.
Affiliations
University of Washington Medical Center (US)
Corresponding author
Crispe, Ian N
ORCID
Venue
Clinical & Translational Immunology
Publisher
Wiley
Published
2016-11
Volume
5
Issue
11
Pages
e113-e113
ISSN
2050-0068 (ISSN-L)
DOI
10.1038/cti.2016.62
PMC
PMC5133365
OpenAlex
W2546644646
Cited by
97
References
104
Citations by year
2026: 5 · 2025: 5 · 2024: 8 · 2023: 13 · 2022: 15 · 2021: 7 · 2020: 13 · 2019: 12 · 2018: 10 · 2017: 9
FWCI
1.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical & Translational Immunology (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords
monocytes, liver injury, liver repair, Ly6Chi monocytes, monocyte-derived macrophages, innate immunity, liver fibrosis, chronic inflammation, hepatocellular carcinoma, inflammation resolution

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