Frustrated Alzheimer’s researchers seek better lab mice
Open accessAbstract
Several projects are trying to develop animal models that more closely mimic how the brain disease affects people. Several projects are trying to develop animal models that more closely mimic how the brain disease affects people.
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It typically requires additional expression of human tau harboring mutations associated with primary tauopathy or seeding mutant human APP knock-in mouse brain with human AD brain-derived tau to develop tau pathology in mouse models.
“It typically requires additional expression of human tau harboring mutations associated with primary tauopathy (94–96) or seeding mutant human APP knock-in mouse brain with human AD brain-derived tau (97) to develop the tau pathology.”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [96]
The cited portion of the sentence concerns seeding mutant human APP knock-in mouse brains with human Alzheimer’s disease brain-derived tau. The article discusses mice engineered to show amyloid plaques and tau tangles (p. 2), but does not describe that seeding method; searches for tau seeding and APP knock-in mice found no supporting passage. (LLM, conf=0.74)
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Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming
Sun, Z., Kwon, J.-S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., et al. (2024) · Science · doi:10.1126/science.adl2992 · Cited by 77 · see citing works
“It typically requires additional expression of human tau harboring mutations associated with primary tauopathy (94–96) or seeding mutant human APP knock-in mouse brain with human AD brain-derived tau (97) to develop the tau pathology.”
Toward improved <i>in vitro</i> models of human cancer
Ayuso, J. M., Park, K.-Y., Virumbrales-Muñoz, M., & Beebe, D. J. (2021) · APL Bioengineering · doi:10.1063/5.0026857 · Cited by 40 · see citing works
- Authors
- Reardon, S.
- Corresponding author
- Reardon, Sara
- Venue
- Nature
- Published
- 2018-11-21
- Volume
- 563
- Issue
- 7733
- Pages
- 611-612
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2901006118
- Cited by
- 35
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 1
- Type
- other
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature (publishedVersion, other-oa)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, animal models, transgenic mice, disease modeling
- MeSH terms
- Alzheimer Disease, Animals, Animals, Wild, Disease Models, Animal, Genetic Engineering, Humans, Inflammation, Memory, Mice, Inbred Strains, Amyloid beta-Peptides, Aspartic Acid Endopeptidases, Neurofibrillary Tangles, tau Proteins, Age of Onset, Genetic Predisposition to Disease, Mice, Amyloid Precursor Protein Secretases, Plaque, Amyloid, Diet, High-Fat, Gene-Environment Interaction
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