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Association between celiac disease and primary lactase deficiency
Abstract
Primary lactase deficiency (PLD) is a common inherited condition caused by a reduced activity of lactase. Two single-nucleotide polymorphisms C/T(-13910) and G/A(-22018) upstream of the lactase gene are associated with lactase nonpersistence. In celiac disease (CD) patients, lactose intolerance could be due to secondary lactase deficiency and to PLD. The aim of this study were to evaluate the association of PLD and CD using genetic test, and to define the prevalence of PLD in celiac subjects compared with a control population. A total of 188 controls and 92 biopsy-proven CD patients were included in the study. More than 70% of all subjects were found homozygous for the polymorphisms. Differences in the prevalence of PLD were not found between CD patients and controls.In conclusions, the hereditary lactase deficiency is frequent in Italian CD children as in control population.
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The prevalence of genotypes predisposing to adult-onset primary hypolactasia in celiac disease patients is comparable to the rate within the general population.
“The prevalence of genotypes predisposing to adult-onset primary hypolactasia in CD patients is comparable to the rate within the general population (62, 63).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [62]
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ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease.
Mearin, M. L., Agardh, D., Antunes, H., Al‐toma, A., Auricchio, R., Castillejo, G., Catassi, C., Ciacci, C., Discepolo, V., Dolinsek, J., et al. (2022) · Journal of pediatric gastroenterology and nutrition · doi:10.1097/mpg.0000000000003540 · Cited by 186
Metadata
- Authors
- Basso, M. S., Luciano, R., Ferretti, F., Muraca, M., Panetta, F., Bracci, F., Ottino, S., & Diamanti, A.
- Affiliations
- Bambino Gesù Children's Hospital (IT)
- Corresponding author
- Basso, M S
- Venue
- European Journal of Clinical Nutrition
- Published
- 2012-12
- Volume
- 66
- Issue
- 12
- Pages
- 1364-1365
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- OpenAlex
- W2003159102
- Cited by
- 15
- References
- 0
- Citations by year
- 2026: 2 · 2022: 3 · 2020: 1 · 2019: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 1
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Digestive system and related health
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- celiac disease, lactase non-persistence, lactose intolerance, secondary lactase deficiency, prevalence, genetic association, children
- MeSH terms
- Adolescent, Celiac Disease, Child, Child, Preschool, Deficiency Diseases, Female, Homozygote, Humans, Italy, Male, Prevalence, Case-Control Studies, Polymorphism, Single Nucleotide, Lactase
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