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The emerging role of splicing factors in cancer
Open accessAbstract
Recent progress in global sequence and microarray data analysis has revealed the increasing complexity of the human transcriptome. Alternative splicing generates a huge diversity of transcript variants and disruption of splicing regulatory networks is emerging as an important contributor to various diseases, including cancer. Current efforts to establish the dynamic repertoire of transcripts that are generated in health and disease are showing that many cancer‐associated alternative‐splicing events occur in the absence of mutations in the affected genes. A growing body of evidence reveals changes in splicing‐factor expression that correlate with cancer development, progression and response to therapy. Here, we discuss how recent links between cancer and altered expression of proteins implicated in splicing regulation are bringing the splicing machinery to the fore as a potential target for anticancer treatment.
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Izquierdo, J. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800017200 · Cited by 156
Cited by
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
Graubert, T. A., Shen, D., Ding, L., Okeyo-Owuor, T., Lunn, C. L., Shao, J., Krysiak, K., Harris, C. C., Koboldt, D. C., Larson, D. E., et al. (2012) · Nature Genetics · doi:10.1038/ng.1031 · Cited by 580
Clower, C. V., Chatterjee, D., Wang, Z., Cantley, L. C., Vander Heiden, M. G., & Krainer, A. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914845107 · Cited by 424
Ward, A. J., & Cooper, T. A. (2010) · The Journal of Pathology · doi:10.1002/path.2649 · Cited by 414
Cancer-associated regulation of alternative splicing
Venables, J. P., Klinck, R., Koh, C., Gervais-Bird, J., Bramard, A., Inkel, L., Durand, M., Couture, S., Froehlich, U., Lapointe, E., et al. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1608 · Cited by 342
Tang, Y., Horikawa, I., Ajiro, M., Robles, A. I., Fujita, K., Mondal, A. M., Stauffer, J. K., Zheng, Z.-M., & Harris, C. C. (2013) · Oncogene · doi:10.1038/onc.2012.288 · Cited by 165
Metadata
- Authors
- Grosso, A. R., Martins, S., & Carmo‐Fonseca, M.
- Venue
- EMBO reports
- Published
- 2008-10
- Volume
- 9
- Issue
- 11
- Pages
- 1087-1093
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2101636442
- Cited by
- 179
- References
- 1
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Grosso, A. R., Martins, S., & Carmo‐Fonseca, M. (2008). The emerging role of splicing factors in cancer. EMBO reports. https://doi.org/10.1038/embor.2008.189
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
