The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.
Kindlins: essential regulators of integrin signalling and cell-matrix adhesion
Open accessAbstract
Integrin-mediated cell-ECM (extracellular matrix) adhesion is a fundamental process that controls cell behaviour. For correct cell-ECM adhesion, both the ligand-binding affinity and the spatial organization of integrins must be precisely controlled; how integrins are regulated, however, is not completely understood. Kindlins constitute a family of evolutionarily conserved cytoplasmic components of cell-ECM adhesions that bind to beta-integrin cytoplasmic tails directly and cooperate with talin in integrin activation. In addition, kindlins interact with many components of cell-ECM adhesions--such as migfilin and integrin-linked kinase--to promote cytoskeletal reorganization. Loss of kindlins causes severe defects in integrin signalling, cell-ECM adhesion and cytoskeletal organization, resulting in early embryonic lethality (kindlin-2), postnatal lethality (kindlin-3) and Kindler syndrome (kindlin-1). It is therefore clear that kindlins, together with several other integrin-proximal proteins, are essential for integrin signalling and cell-ECM adhesion regulation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“FERMT1 (also known as kindlin-1) directly binds the cytoplasmic tail of β1 integrin to enable signaling and mediate cell spreading and controls murine cutaneous stem cell homeostasis (Kloeker et al., 2004, Larjava et al., 2008, Rognoni et al., 2014).”
From Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma (2020) · cites this paper as Larjava et al., 2008
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“FERMT1 (also known as kindlin-1) directly binds the cytoplasmic tail of β1 integrin to enable signaling and mediate cell spreading and controls murine cutaneous stem cell homeostasis (Kloeker et al., 2004, Larjava et al., 2008, Rognoni et al., 2014).”
From Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma (2020) · cites this paper as Larjava et al., 2008
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606
Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation
Tadokoro, S., Shattil, S. J., Eto, K., Tai, V., Liddington, R., de Pereda, J. M., Ginsberg, M. H., & Calderwood, D. (2003) · Science · doi:10.1126/science.1086652 · Cited by 1,211
Ramirez, A., Fisher, G., George, E. L., Sanning, E., Forouzani, M., Allen, J., Bak, R., Halley, W., Wheeler, G., her, et al. (2003) · Cited by 960
Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins
Kim, M., Carman, C. V., & Springer, T. A. (2003) · Science · doi:10.1126/science.1084174 · Cited by 786
Calderwood, D. A., Zent, R., Grant, R., Rees, D. J. G., Hynes, R. O., & Ginsberg, M. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28071 · Cited by 720
Kindlin-3 is essential for integrin activation and platelet aggregation
Moser, M., Nieswandt, B., Ussar, S., Požgajová, M., & Fässler, R. (2008) · Nature Medicine · doi:10.1038/nm1722 · Cited by 700
Krüger, M., Moser, M., Ussar, S., Thievessen, I., Luber, C. A., Forner, F., Schmidt, S., Zanivan, S., Fässler, R., & Mann, M. (2008) · Cell · doi:10.1016/j.cell.2008.05.033 · Cited by 680
Structural Basis of Integrin Activation by Talin
Wegener, K. L., Partridge, A. W., Han, J., Pickford, A. R., Liddington, R., Ginsberg, M. H., & Campbell, I. D. (2007) · Cell · doi:10.1016/j.cell.2006.10.048 · Cited by 677
Pearson, M. A., Reczek, D., Bretscher, A. P., & Karplus, P. A. (2000) · Cell · doi:10.1016/s0092-8674(00)80836-3 · Cited by 614
Hughes, P. E., Díaz‐González, F., Leong, L., Wu, C., McDonald, J. A., Shattil, S. J., & Ginsberg, M. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.12.6571 · Cited by 571
Self-citationVinogradova, O., Vėlyvis, A., Velyviene, A., Hu, B., Haas, T. A., Plow, E. F., & Qin, J. (2002) · Cell · doi:10.1016/s0092-8674(02)00906-6 · Cited by 529
Self-citationStructural Determinants of Integrin Recognition by Talin
García‐Álvarez, B., de Pereda, J. M., Calderwood, D., Ulmer, T. S., Critchley, D. R., Campbell, I. D., Ginsberg, M. H., & Liddington, R. (2003) · Molecular Cell · doi:10.1016/s1097-2765(02)00823-7 · Cited by 514
Kindlin-2 controls bidirectional signaling of integrinsPreprint
Montañez, E., Ussar, S., Schifferer, M., Bösl, M. R., Zent, R., Moser, M., & Fässler, R. (2008) · Genes & Development · doi:10.1101/gad.469408 · Cited by 452
Reconstructing and Deconstructing Agonist-Induced Activation of Integrin αIIbβ3
Han, J., Lim, C. J., Watanabe, N., Soriani, A., Ratnikov, B. I., Calderwood, D., Puzon-McLaughlin, W., Lafuente, E. M., Boussiotis, V. A., Shattil, S. J., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.035 · Cited by 447
The Phosphotyrosine Binding-like Domain of Talin Activates Integrins
Calderwood, D., Yan, B., de Pereda, J. M., García‐Álvarez, B., Fujioka, Y., Liddington, R., & Ginsberg, M. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111996200 · Cited by 412
Tu, Y., Wu, S., Shi, X., Chen, K., & Wu, C. (2003) · Cell · doi:10.1016/s0092-8674(03)00163-6 · Cited by 375
Self-citationKindlin-2 (Mig-2): a co-activator of β3 integrins
Ma, Y., Qin, J., Wu, C., & Plow, E. F. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710196 · Cited by 352
Self-citationSiegel, D. H., Ashton, G. H. S., Penagos, H., Lee, J. V., Feiler, H. S., Wilhelmsen, K. C., South, A. P., Smith, F. J. D., Prescott, A. R., Wessagowit, V., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/376609 · Cited by 346
C. elegans PAT-4/ILK Functions as an Adaptor Protein within Integrin Adhesion Complexes
Mackinnon, A. C., Qadota, H., Norman, K. R., Moerman, D. G., & Williams, B. D. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00810-2 · Cited by 319
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis
Petrich, B. G., Marchese, P., Ruggeri, Z. M., Spiess, S., Weichert, R. A. M., Ye, F., Tiedt, R., Skoda, R. C., Monkley, S. J., Critchley, D. R., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071800 · Cited by 310
Nieswandt, B., Moser, M., Pleines, I., Varga-Szabó, D., Monkley, S., Critchley, D. R., & Fässler, R. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071827 · Cited by 273
Jobard, F. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg097 · Cited by 259
The Kindlins: Subcellular localization and expression during murine development
Ussar, S., Wang, H., Linder, S., Fässler, R., & Moser, M. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.06.030 · Cited by 255
Chen, Y. P., Djaffar, I., Pidard, D., Steiner, B., Cieutat, A.-M., Caen, J., & Rosa, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10169 · Cited by 226
CONGENITAL POIKILODERMA WITH TRAUMATIC BULLA FOKMATION AND PROGRESSIVE CUTANEOUS ATROPHY.
Kindler, T. (1954) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1954.tb12598.x · Cited by 207
Critchley, D. R., & Gingras, A. R. (2008) · Journal of Cell Science · doi:10.1242/jcs.018085 · Cited by 206
Rogalski, T. M., Mullen, G. P., Gilbert, M., Williams, B. D., & Moerman, D. G. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.1.253 · Cited by 195
Integrin Bidirectional Signaling: A Molecular View
Qin, J., Vinogradova, O., & Plow, E. F. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020169 · Cited by 189
Self-citationThe MIG-2/Integrin Interaction Strengthens Cell-Matrix Adhesion and Modulates Cell Motility
Shi, X., Ma, Y., Tu, Y., Chen, K., Wu, S., Fukuda, K., Qin, J., Plow, E. F., & Wu, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611680200 · Cited by 182
Self-citationKloeker, S., Major, M. B., Calderwood, D. A., Ginsberg, M. H., Jones, D. A., & Beckerle, M. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307978200 · Cited by 163
Dowling, J. J., Gibbs, E. M., Russell, M. W. W., Goldman, D. J., Minarcik, J. C., Golden, J. A., & Feldman, E. L. (2008) · Circulation Research · doi:10.1161/circresaha.107.161489 · Cited by 161
The PINCH–ILK–parvin complexes: assembly, functions and regulation
Wu, C. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.01.006 · Cited by 149
Self-citationHerz, C., Aumailley, M., Schulte, C., Schlötzer-Schrehardt, U. M., Bruckner‐Tuderman, L., & Has, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606259200 · Cited by 142
Chen, Y., O'Toole, T., Ylänne, J., Rosa, J., & Ginsberg, M. (1994) · Blood · doi:10.1182/blood.v84.6.1857.bloodjournal8461857 · Cited by 125
Petrich, B. G., Fogelstrand, P., Partridge, A. W., Yousefi, N., Ablooglu, A. J., Shattil, S. J., & Ginsberg, M. H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31024 · Cited by 119
Lai-Cheong, J. E., Ussar, S., Arita, K., Hart, I. R., & McGrath, J. A. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.58 · Cited by 96
Chronic colitis due to an epithelial barrier defect: the role of kindlin‐1 isoforms
Kern, J. S., Herz, C., Haan, E., Moore, D., Nottelmann, S., von Lilien, T., Greiner, P., Schmitt-Graeff, A. H., OPITZ, O. G., Bruckner‐Tuderman, L., et al. (2007) · The Journal of Pathology · doi:10.1002/path.2253 · Cited by 91
Migfilin and its binding partners: from cell biology to human diseases
Wu, C. (2005) · Journal of Cell Science · doi:10.1242/jcs.01639 · Cited by 84
Self-citationWeinstein, E. J., Bourner, M. J., Head, R., Zakeri, H., Bauer, C., & Mazzarella, R. A. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(03)00035-8 · Cited by 80
The Cytoplasmic Domain of αIIbβ3
Haas, T. A., & Plow, E. F. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6017 · Cited by 76
Self-citationRegulation of Integrin αIIbβ3 Activation by Distinct Regions of Its Cytoplasmic Tails
Ma, Y., Yang, J., Pesho, M. M., Vinogradova, O., Qin, J., & Plow, E. F. (2006) · Biochemistry · doi:10.1021/bi060279h · Cited by 70
Self-citationZhang, Y., Tu, Y., Gkretsi, V., & Wu, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512107200 · Cited by 68
Self-citationShimizu, H. (1997) · Archives of Dermatology · doi:10.1001/archderm.1997.03890450057007 · Cited by 64
Kindler Syndrome and Periodontal Disease: Review of the Literature and a 12‐Year Follow‐Up Case
Wiebe, C. B., Petricca, G., Häkkinen, L., Jiang, G., Wu, C., & Larjava, H. (2008) · Journal of Periodontology · doi:10.1902/jop.2008.070167 · Cited by 63
Self-citationGenetic, biochemical and structural approaches to talin function
Critchley, D. R. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051308 · Cited by 51
A Suppressive Role of Mitogen Inducible Gene-2 in Mesenchymal Cancer Cell Invasion
Shi, X., & Wu, C. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-2026 · Cited by 47
Self-citationAbnormal deposition of type VII collagen in Kindler syndrome
Wiebe, C. B., & Larjava, H. (1999) · Archives of Dermatological Research · doi:10.1007/s004030050377 · Cited by 32
Self-citationIntegrin activation—the importance of a positive feedback
Iber, D., & Campbell, I. D. (2006) · Bulletin of Mathematical Biology · doi:10.1007/s11538-005-9049-5 · Cited by 21
Flagged first, then by citations
1 of the 49 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Barczyk, M., Carracedo, S., & Gullberg, D. (2010) · Cell and Tissue Research · doi:10.1007/s00441-009-0834-6 · Cited by 1,512
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma
Ji, A. L., Rubin, A. J., Thrane, K., Jiang, S., Reynolds, D. L., Meyers, R. M., Guo, M. G., George, B. M., Mollbrink, A., Bergenstråhle, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.039 · Cited by 1,117
“FERMT1 (also known as kindlin-1) directly binds the cytoplasmic tail of b1 integrin to enable signaling and mediate cell spreading and controls murine cutaneous stem cell homeostasis (Kloeker et al., 2004; Larjava et al., 2008; Rognoni et al., 2014).”
BackgroundPhysical influences of the extracellular environment on cell migration
Charras, G., & Sahai, E. A. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3897 · Cited by 678
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation
Svensson, L. M., Howarth, K. M., McDowall, A., Patzak, I. M., Evans, R., Ussar, S., Moser, M., Metìn, A., Fried, M., Tomlinson, I. P. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1931 · Cited by 418
The insider's guide to leukocyte integrin signalling and function
Hogg, N., Patzak, I. M., & Willenbrock, F. W. (2011) · Nature reviews. Immunology · doi:10.1038/nri2986 · Cited by 402
Metadata
- Authors
- Larjava, H., Plow, E. F., & Wu, C.
- Affiliations
- University of British Columbia (CA)
- Cleveland Clinic (US)
- University of Pittsburgh (US)
- Venue
- The EMBO Reports
- Published
- 2008-11-07
- Volume
- 9
- Issue
- 12
- Pages
- 1203-1208
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC2603460
- OpenAlex
- W2159437476
- Cited by
- 268
- References
- 49
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 7 · 2023: 7 · 2022: 14 · 2021: 16 · 2020: 12 · 2019: 13 · 2018: 11 · 2017: 15 · 2016: 10 · 2015: 12 · 2014: 21 · 2013: 21 · 2012: 16
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- EMBO Reports (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (P01HL073311)
- National Institute of General Medical Sciences (GM 65188, R01GM065188)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK54639, R01DK054639)
- National Institute of Dental and Craniofacial Research (R01DE016099, DE016099)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- kindlin, integrin signaling, cell-matrix adhesion, talin, integrin activation, integrin-linked kinase, cytoskeletal organization, Kindler syndrome, kindlin-1, Kindlin-2, kindlin-3, embryonic lethality
- MeSH terms
- Animals, Carrier Proteins, Cell Adhesion, Disease, Humans, Signal Transduction, Integrins, Cell-Matrix Junctions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
