Building and remodelling Cullin–RING E3 ubiquitin ligases
Open accessAbstract
Cullin-RING E3 ubiquitin ligases (CRLs) control a plethora of biological pathways through targeted ubiquitylation of signalling proteins. These modular assemblies use substrate receptor modules to recruit specific targets. Recent efforts have focused on understanding the mechanisms that control the activity state of CRLs through dynamic alterations in CRL architecture. Central to these processes are cycles of cullin neddylation and deneddylation, as well as exchange of substrate receptor modules to re-sculpt the CRL landscape, thereby responding to the cellular requirements to turn over distinct proteins in different contexts. This review is focused on how CRLs are dynamically controlled with an emphasis on how cullin neddylation cycles are integrated with receptor exchange.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CRLs are the largest family of E3 ubiquitin ligases.
“CRLs are the largest family of E3 ubiquitin ligases.”
From Chasing molecular glue degraders: screening approaches (2022) · cites this paper as [137]
CRLs orchestrate an impressive array of eukaryotic processes and their dysregulation underlies many pathologies.
“CRLs orchestrate an impressive array of eukaryotic processes and their dysregulation underlies many pathologies.”
From Chasing molecular glue degraders: screening approaches (2022) · cites this paper as [137]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 128 · Cited by 327
- Authors
- Lydeard, J. R., Schulman, B. A., & Harper, J. W.
- Affiliations
- Harvard University (US)
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Harper, J Wade
- Venue
- The EMBO Reports
- Published
- 2013-11-15
- Volume
- 14
- Issue
- 12
- Pages
- 1050-1061
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC3849489
- OpenAlex
- W2050723187
- Cited by
- 327
- References
- 128
- Citations by year
- 2026: 16 · 2025: 12 · 2024: 22 · 2023: 16 · 2022: 28 · 2021: 36 · 2020: 40 · 2019: 22 · 2018: 28 · 2017: 30 · 2016: 28 · 2015: 32 · 2014: 17
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- EMBO Reports (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute (P30CA021765)
- Damon Runyon Cancer Research Foundation
- American Lebanese Syrian Associated Charities (P30CA021765)
- National Institutes of Health (NS083524, GM095567)
- National Institute on Aging (R01AG11085, R01AG011085)
- National Cancer Institute (P30CA021765)
- National Institute of General Medical Sciences (R01GM095567, R01GM069530)
- National Institute of Neurological Disorders and Stroke (R01NS083524)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- Cullin-RING E3 ubiquitin ligase, cullin neddylation, deneddylation, ubiquitination, protein turnover
- MeSH terms
- COP9 Signalosome Complex, Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Peptide Hydrolases, Protein Binding, Transcription Factors, Ubiquitins, Cullin Proteins, Multiprotein Complexes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
