On the choice of mathematical models for the estimation of lethal gene equivalents in man.
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A range of mathematical models and error distributions was used to examine the validity of linear regression methods for the calculation of lethal gene equivalents. Because of the restricted span of inbreeding coefficient F values available in human studies and the limited number of data points, equivalent results were obtained with all combinations tested. It was concluded that linear regressions should be employed only for the detection of significant inbreeding effects in man and that their application to the estimation of lethal gene equivalents was not warranted.
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The estimate of the combined effect of recessive deleterious mutations is highly sensitive to the choice of the regression model.
“Moreover, due to the restricted range of F and the small number of data points, the estimate of the combined effect of recessive deleterious mutations is highly sensitive to the choice of the regression model (Makov and Bittles 1986).”
From An Estimate of the Average Number of Recessive Lethal Mutations Carried by Humans (2015) · cites this paper as Makov and Bittles 1986
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References 21 · Cited by 10
Research works printed but not linked: 2
- [2]2. BAKER. R. J. AND NELDER, J. A. 1978. GUM Manual, (release 3), Numerical Algorithms Group, Oxford.
- [3]3. BEMISS, S. M. 1958. Report on influence of marriages of con- sanguinity upon offspring. Trans. Amer. Med. Assoc. 11, 3 19-425.
- Authors
- Makov, E., & Bittles, A. H.
- Affiliations
- Queen Mary University of London (GB)
- King's College London (GB)
- ORCID
- Bittles, A H
- Venue
- Heredity
- Published
- 1986-12
- Volume
- 57
- Issue
- 3
- Pages
- 377-380
- ISSN
- 0018-067X (ISSN-L)
- 1365-2540
- OpenAlex
- W2049678716
- Cited by
- 10
- References
- 21
- Citations by year
- 2018: 1 · 2015: 1
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Heredity (publishedVersion)
- PubMed (publishedVersion)
- Murdoch University Research Portal (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- inbreeding coefficient, inbreeding depression, linear regression, error distribution, mathematical model, inbreeding effects
- MeSH terms
- Female, Fetal Death, Genes, Lethal, Humans, Inbreeding, Infant Mortality, Infant, Newborn, Models, Genetic, Pregnancy, Probability
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