Cited by 296Renin-Angiotensin System StudiesCoagulation, Bradykinin, Polyphosphates, and AngioedemaEicosanoids and Hypertension Pharmacology

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Devil and angel in the renin–angiotensin system: ACE–angiotensin II–AT1 receptor axis vs. ACE2–angiotensin-(1–7)–Mas receptor axis

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Iwai, Masaru, Horiuchi, Masatsugu·2009·Hypertension Research

DOI 10.1038/hr.2009.74PMC PMC7091931

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Abstract

Recent studies have established a new regulatory axis in the renin-angiotensin system (RAS). In this axis, angiotensin (Ang)-(1-7) is finally produced from Ang I or Ang II by the catalytic activity of angiotensin-converting enzyme 2 (ACE2). Ang-(1-7) shows actions different from those of AT(1) receptor stimulation, such as vasodilatation, natriuresis, anti-proliferation and an increase in the bradykinin-NO (nitric oxide) system. As the catalytic efficiency of ACE2 is approximately 400-fold higher with Ang II as a substrate than with Ang I, this axis is possibly acting as a counter-regulatory system against the ACE/Ang II/AT(1) receptor axis. The signaling pathway of the ACE2-Ang-(1-7) axis has not yet been totally and clearly understood. However, a recent report suggests that the Mas oncogene acts as a receptor for Ang-(1-7). Intracellular signaling through Mas is not clear yet. Several factors such as Akt phosphorylation, protein kinase C activation and mitogen-activated protein (MAP) kinase inhibition seem to be involved in this signaling pathway. Further investigations are needed to clarify the regulation and mechanism of action of ACE2 and Ang-(1-7). However, this second axis through ACE2 and Ang-(1-7) in RAS can be an important target for the therapy of cardiovascular and metabolic disorders.

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Donoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M., Stagliano, N., Donovan, M., Woolf, B., Robison, K., Jeyaseelan, R., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.5.e1 · Cited by 2,485
International Union of Pharmacology. XXIII. The Angiotensin II Receptors
Marc De Gasparo, B., Catt, K. J., Inagami, T., Wright, J. W., & Unger, T. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01458-3 · Cited by 2,131
A Human Homolog of Angiotensin-converting Enzyme
Tipnis, S. R., Hooper, N. M., Hyde, R., Karran, E. H., Christie, G., & Turner, A. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002615200 · Cited by 2,041
Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas
Santos, R. A. S., Silva, A. C. S. E., Maric, C., Silva, D. M. R., Machado, R. P., de Buhr, I., Heringer‐Walther, S., Pinheiro, S. V. B., Lopes, M. T., Bäder, M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432869100 · Cited by 1,805
Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase
Vickers, C., Hales, P., Kaushik, V. K., Dick, L. R., Gavin, J. M., Tang, J., Godbout, K., Parsons, T. F., Baronas, E., Hsieh, F., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200581200 · Cited by 1,406
Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
Murphy, T. J., Alexander, R. W., Griendling, K. K., Runge, M. S., & Bernstein, K. E. (1991) · Nature · doi:10.1038/351233a0 · Cited by 1,250
Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis
Elliott, W. J., & Meyer, P. M. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60108-1 · Cited by 1,016
Upregulation of Angiotensin-Converting Enzyme 2 After Myocardial Infarction by Blockade of Angiotensin II Receptors
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Ferrario, C. M., Chappell, M. C., Tallant, E. A., Brosnihan, K. B., & Diz, D. I. (1997) · Hypertension · doi:10.1161/01.hyp.30.3.535 · Cited by 509
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Benigni, A., Corna, D., Zoja, C., Sonzogni, A., Latini, R., Salio, M., Conti, S., Rottoli, D., Longaretti, L., Cassis, P., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36703 · Cited by 486

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Santos RA, Ferreira AJ, E Silva AC . Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis. Exp Physiol 2008; 93: 519–527. · DOI

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Authors: Iwai, M., & Horiuchi, M.
Affiliations: Ehime University (JP)
Corresponding author: Horiuchi, Masatsugu
Venue: Hypertension Research
Publisher: Springer Science and Business Media LLC
Published: 2009-05-22
Volume: 32
Issue: 7
Pages: 533-536
ISSN: 0916-9636 (ISSN-L)
1348-4214
DOI: 10.1038/hr.2009.74
PMC: PMC7091931
OpenAlex: W2067142583
Cited by: 296
References: 37
Citations by year: 2026: 9 · 2025: 9 · 2024: 11 · 2023: 20 · 2022: 21 · 2021: 29 · 2020: 29 · 2019: 12 · 2018: 14 · 2017: 10 · 2016: 17 · 2015: 27 · 2014: 19 · 2013: 19 · 2012: 23
FWCI: 2.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Hypertension Research (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: renin-angiotensin system, angiotensin-(1-7), angiotensin-converting enzyme 2, Mas receptor, angiotensin II type 1 receptor, angiotensin II, vasodilation, sodium excretion, Akt phosphorylation, protein kinase C, MAP kinase inhibition, cardiovascular disease treatment
MeSH terms: Angiotensin-Converting Enzyme 2, Proto-Oncogene Mas, Angiotensin I, Animals, Humans, Peptidyl-Dipeptidase A, Peptide Fragments, Proto-Oncogene Proteins, Renin-Angiotensin System, Signal Transduction, Receptors, G-Protein-Coupled, Receptor, Angiotensin, Type 1

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Devil and angel in the renin–angiotensin system: ACE–angiotensin II–AT1 receptor axis vs. ACE2–angiotensin-(1–7)–Mas receptor axis

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