The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
MHC class II‐associated proteins in B‐cell exosomes and potential functional implications for exosome biogenesis
Abstract
Professional antigen‐presenting cells secrete major histocompatibility complex class II (MHC II) carrying exosomes with unclear physiological function(s). Exosomes are first generated as the intraluminal vesicles (ILVs) of a specific type of multivesicular body, and are then secreted by fusion of this compartment with the plasma membrane. We have previously shown that in contrast to the sorting of MHC II at lysosomally targeted multivesicular bodies, sorting of MHC II into exosomes does not rely on MHC II ubiquitination. In search for proteins that drive the incorporation of MHC II into exosomes or functionally discriminate exosomal from plasma membrane MHC II, we first analyzed the total proteome of highly purified B cell‐derived exosomes using sensitive and accurate mass spectrometry (MS), and identified 539 proteins, including known and not previously identified constituents. Using quantitative MS, we then identified a small subset of proteins that were specifically co‐immunoprecipitated with MHC II from detergent‐solubilized exosomes. These include HSC71, HSP90, 14‐3‐3ε, CD20 and pyruvate kinase type M2 (PKM2), and we speculate on the functionality of their interaction with exosomal MHC II.
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Self-citationY-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction
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Metadata
- Authors
- Buschow, S. I., van Balkom, B. W. M., Aalberts, M., Heck, A. J. R., Wauben, M., & Stoorvogel, W.
- Venue
- Immunology & Cell Biology
- Publisher
- Wiley
- Published
- 2010-05-11
- Volume
- 88
- Issue
- 8
- Pages
- 851-856
- ISSN
- 0004-945X (ISSN-L)
- 0818-9641
- 1440-1711
- OpenAlex
- W1969095017
- Cited by
- 275
- References
- 59
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Buschow, S. I., van Balkom, B. W. M., Aalberts, M., Heck, A. J. R., Wauben, M., & Stoorvogel, W. (2010). MHC class II‐associated proteins in B‐cell exosomes and potential functional implications for exosome biogenesis. Immunology & Cell Biology. https://doi.org/10.1038/icb.2010.64
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