Imaging macrophage development and fate in atherosclerosis and myocardial infarction
Open accessAbstract
Macrophages are central regulators of disease progression in both atherosclerosis and myocardial infarction (MI). In atherosclerosis, macrophages are the dominant leukocyte population that influences lesional development. In MI, which is caused by atherosclerosis, macrophages accumulate readily and have important roles in inflammation and healing. Molecular imaging has grown considerably as a field and can reveal biological process at the molecular, cellular and tissue levels. Here, we explore how various imaging modalities, from intravital microscopy in mice to organ-level imaging in patients, are contributing to our understanding of macrophages and their progenitors in cardiovascular disease.
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References 77 · Cited by 23
- Authors
- Swirski, F. K., & Nahrendorf, M.
- Affiliations
- Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School Boston MA USA
- Harvard University (US)
- ORCID
- Nahrendorf, Matthias
- Venue
- Immunology & Cell Biology
- Publisher
- Wiley
- Published
- 2012-12-04
- Volume
- 91
- Issue
- 4
- Pages
- 297-303
- ISSN
- 0004-945X (ISSN-L)
- 0818-9641
- 1440-1711
- PMC
- PMC3875224
- OpenAlex
- W2093299684
- Cited by
- 23
- References
- 77
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 4 · 2019: 4 · 2018: 2 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 4
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Immunology and Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL095612, R01HL095629, R01HL096576)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- macrophages, macrophage development, atherosclerosis, myocardial infarction, molecular imaging, intravital microscopy, macrophage progenitors, inflammation, lesion progression, cardiovascular disease
- MeSH terms
- Animals, Cell Movement, Diagnostic Imaging, Humans, Macrophages, Monocytes, Myocardial Infarction, Atherosclerosis
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