Induction of memory cytotoxic T cells to influenza A virus and subsequent viral clearance is not modulated by PB1-F2-dependent inflammasome activation.
Open accessAbstract
Expression of the viral virulence protein PB1-F2 during infection has been linked to NLRP3 inflammasome complex activation in macrophages and induction of early inflammatory events enhancing immunopathology during influenza disease. We sought to determine whether PB1-F2-specific NLRP3 inflammasome activation influenced the magnitude and/or robustness of the CD8(+) T-cell responses specific for conserved viral antigens and subsequent virus elimination. Using murine heterosubtypic viral infection models, we showed that mice infected with virus unable to produce PB1-F2 protein showed no deficit in the overall magnitude and functional memory responses of CD8(+) T cells established during the effector phase compared with those infected with wild-type PB1-F2-expressing virus and were equally capable of mounting robust recall responses. These data indicate that while expression of PB1-F2 protein can induce inflammatory events, the capacity to generate memory CD8(+) T cells specific for immunodominant viral epitopes remains uncompromised.
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Influenza A virus can produce viral cytotoxin PB1-F2, which increases inflammation, host cell damage, bacterial adherence, mortality and morbidity.
“Influenza A virus can produce a viral cytotoxin PB1-F2 (Conenello and Palese, 2007; Iverson et al., 2011) which plays a role in increasing inflammation and therefore host cell damage and bacterial adherence, increasing mortality and morbidity (Lee et al., 2016).”
From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Lee et al., 2016
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References 41 · Cited by 7
Research works printed but not linked: 1
- McAuley JL et al. Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease. PLoS Pathogens 2013; 9: e1003392. 23737748 PMC3667782
- Authors
- Lee, P. (. Y., Bird, N., MacKenzie‐Kludas, C., Mansell, A., Kedzierska, K., Brown, L., & McAuley, J.
- Affiliations
- Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity Melbourne Victoria Australia
- The University of Melbourne (AU)
- Hudson Institute of Medical Research (AU)
- Corresponding author
- McAuley, Julie
- Venue
- Immunology & Cell Biology
- Publisher
- Wiley
- Published
- 2016-01-26
- Volume
- 94
- Issue
- 5
- Pages
- 439-446
- ISSN
- 0004-945X (ISSN-L)
- 0818-9641
- 1440-1711
- PMC
- PMC4890051
- OpenAlex
- W2217738229
- Cited by
- 7
- References
- 41
- Citations by year
- 2022: 1 · 2021: 2 · 2020: 1 · 2017: 2 · 2016: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Immunology and Cell Biology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Health and Medical Research Council (1071916)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- influenza A virus, PB1-F2, NLRP3 inflammasome, CD8+ T cell responses, viral clearance, immunodominant epitopes, viral virulence factors
- MeSH terms
- Animals, Female, Immunologic Memory, Inflammation, Mice, Inbred C57BL, Orthomyxoviridae Infections, Influenza A virus, Species Specificity, T-Lymphocytes, Cytotoxic, Viral Proteins, CD8-Positive T-Lymphocytes, Interleukin-1beta, Inflammasomes
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