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Cited by 122Regulation of Appetite and ObesityPharmacology and Obesity TreatmentAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options

Fani, L, Bak, S, Delhanty, P, van Rossum, E F C, van den Akker, E L T·2014·International Journal of Obesity
DOI 10.1038/ijo.2013.80
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Abstract

Obesity is one of the greatest public health challenges of the 21st century. Obesity is currently responsible for ∼0.7-2.8% of a country's health costs worldwide. Treatment is often not effective because weight regulation is complex. Appetite and energy control are regulated in the brain. Melanocortin-4 receptor (MC4R) has a central role in this regulation. MC4R defects lead to a severe clinical phenotype with lack of satiety and early-onset severe obesity. Preclinical research has been carried out to understand the mechanism of MC4R regulation and possible effectors. The objective of this study is to systematically review the literature for emerging pharmacological obesity treatment options. A systematic literature search was performed in PubMed and Embase for articles published until June 2012. The search resulted in 664 papers matching the search terms, of which 15 papers remained after elimination, based on the specific inclusion and exclusion criteria. In these 15 papers, different MC4R agonists were studied in vivo in animal and human studies. Almost all studies are in the preclinical phase. There are currently no effective clinical treatments for MC4R-deficient obese patients, although MC4R agonists are being developed and are entering phase I and II trials.

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Crossref · 10.1038/ijo.2013.80

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  1. Raun K, Conde-Frieboes KW, Sensfuss U, Wulff BS . A long acting, selective MC4 receptor agonist effectively reduces appetite and bodyweight in diet induced obese rats. Obes Rev 2011; 12: 279.

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Metadata

Authors
Fani, L., Bak, S., Delhanty, P., van Rossum, E. F. C., & van den Akker, E. L. T.
Affiliations
Erasmus MC (NL)
ORCID
Venue
International Journal of Obesity
Publisher
Springer Science and Business Media LLC
Published
2013-06-18
Volume
38
Issue
2
Pages
163-169
ISSN
  • 0307-0565 (ISSN-L)
  • 1476-5497
DOI
10.1038/ijo.2013.80
OpenAlex
W2019132602
Cited by
121
References
33
Citations by year
2025: 4 · 2024: 4 · 2023: 20 · 2022: 15 · 2021: 6 · 2020: 13 · 2019: 9 · 2018: 6 · 2017: 7 · 2016: 12 · 2015: 16 · 2014: 8 · 2013: 1
FWCI
1.49
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • International Journal of Obesity (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
melanocortin-4 receptor, obesity treatment, MC4R agonist, appetite regulation, energy homeostasis, satiety, body weight regulation, pharmacotherapy
MeSH terms
Acetamides, alpha-MSH, Animals, Appetite Regulation, Energy Intake, Energy Metabolism, Gene Frequency, Genotype, Humans, Obesity, Peptides, Cyclic, Phenotype, Pyrrolidines, Receptors, Cell Surface, Spiro Compounds, Body Mass Index, Anti-Obesity Agents, Receptor, Melanocortin, Type 4

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