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Calcium Overload in Selectively Vulnerable Neurons of the Hippocampus during and after Ischemia: An Electron Microscopy Study in the Rat
Abstract
Light and electron microscopy has been used to study the cytopathological changes in the rat hippocampus directly after a 30-min period of forebrain ischemia and after 30 or 120 min of reperfusion. The fine structural localization of calcium has been demonstrated using the oxalate/pyroantimonate procedure. Cellular changes considered typical of ischemia (swelling of astrocytic processes, distention of mitochondria, condensation of cytoplasm, “ischemic cell change”) are most prominent after 30 min of reperfusion. At this time, dense calcium pyroantimonate deposits are evident in swollen mitochondria in pyramidal and hilar neurons. After 120 min of reperfusion, substantial restitution has occurred; most mitochondria appear normal and there are few calcium deposits. However, a small number of selectively vulnerable neurons (hilar and pyramidal neurons) show dense condensation (ischemic cell change) with multiple vacuoles containing calcium deposits. The role of excessive calcium entry and mitochondrial calcium overload during the reperfusion period in determining the death of selectively vulnerable neurons is discussed.
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Citations
Cited by
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Excitatory amino acid neurotoxicity and neurodegenerative disease
Meldrum, B., & Garthwaite, J. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90184-a · Cited by 1,771
Self-citationCalcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage
Choi, D. W. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90200-7 · Cited by 1,736
Selective vulnerability of the hippocampus in brain ischemia
Schmidt-Kastner, R., & Freund, T. F. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90001-5 · Cited by 888
The role of calcium in apoptosis
Nicotera, P., & Orrenius, S. (1998) · Cell Calcium · doi:10.1016/s0143-4160(98)90116-6 · Cited by 458
Metadata
- Authors
- Simon, R. P., Griffiths, T., Evans, M. C., Swan, J. H., & Meldrum, B. S.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1984-09
- Volume
- 4
- Issue
- 3
- Pages
- 350-361
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W1979668799
- Cited by
- 359
- References
- 0
- FWCI
- 15.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Calcium Overload in Selectively Vulnerable Neurons of the Hippocampus during and after Ischemia: An Electron Microscopy Study in the Rat. https://app.cochat.ai/papers/10.1038/jcbfm.1984.52
- The paper
- Simon, R. P., Griffiths, T., Evans, M. C., Swan, J. H., & Meldrum, B. S. (1984). Calcium Overload in Selectively Vulnerable Neurons of the Hippocampus during and after Ischemia: An Electron Microscopy Study in the Rat. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.1984.52
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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