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Focal Cerebral Ischaemia in the Cat: Treatment with the Glutamate Antagonist MK-801 after Induction of Ischaemia
Open accessAbstract
The effects of the glutamate N-methyl-D-aspartate receptor antagonist MK-801 in reducing ischaemic brain damage have been examined in anaesthetised cats, with drug treatment being initiated 2 h after the induction of cerebral ischaemia. Focal cerebral ischaemia was produced by permanent occlusion of one middle cerebral artery, and the animals were killed 6 h later. The amount of early irreversible ischaemic damage was assessed at 16 predetermined stereotactic planes. Treatment with MK-801 (5 mg/kg, i.v.) 2 h after middle cerebral artery occlusion reduced significantly the volume of ischaemic damage (from 1,625 ± 384 mm 3 of the cerebral hemisphere in vehicle-treated cats to 792 ± 385 mm 3 in MK-801-treated cats). The demonstration of reduced ischaemic brain damage with MK-801, when the agent is administered after the induction of ischaemia, extends the therapeutic potential of such agents in the treatment of focal cerebral ischaemia in humans.
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Citations
Cited by
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Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Excitatory amino acid neurotoxicity and neurodegenerative disease
Meldrum, B., & Garthwaite, J. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90184-a · Cited by 1,771
Tymianski, M., & Tator, C. H. (1996) · Neurosurgery · doi:10.1097/00006123-199606000-00028 · Cited by 313
Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat
Memezawa, H., Minamisawa, H., Smith, M.-L., & Siesj�, B. K. (1992) · Experimental Brain Research · doi:10.1007/bf00229002 · Cited by 310
Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions
Nakamura, H., Strong, A. J., Dohmen, C., Sakowitz, O. W., Vollmar, S., Sué, M., Kracht, L., Hashemi, P., Bhatia, R., Yoshimine, T., et al. (2010) · Brain · doi:10.1093/brain/awq117 · Cited by 212
Metadata
- Authors
- Park, C. K., Nehls, D. G., Graham, D. I., Teasdale, G. M., & McCulloch, J.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1988-10
- Volume
- 8
- Issue
- 5
- Pages
- 757-762
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W1972089392
- Cited by
- 244
- References
- 0
- FWCI
- 20.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Focal Cerebral Ischaemia in the Cat: Treatment with the Glutamate Antagonist MK-801 after Induction of Ischaemia. https://app.cochat.ai/papers/10.1038/jcbfm.1988.124
- The paper
- Park, C. K., Nehls, D. G., Graham, D. I., Teasdale, G. M., & McCulloch, J. (1988). Focal Cerebral Ischaemia in the Cat: Treatment with the Glutamate Antagonist MK-801 after Induction of Ischaemia. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.1988.124
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
