The DOI matches its Crossref record.
Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat
Abstract
The effects of the glutamate N-methyl-D aspartate (NMDA) receptor antagonist, MK-801, upon ischemic brain damage has been examined in anesthetized cats. Focal cerebral ischemia was produced by permanent occlusion of one middle cerebral artery and the animals were killed 6 h later. The amount of early ischemic damage was assessed in coronal sections at 16 predetermined stereotactic planes. Pretreatment with MK-801 (5 mg/kg, i.v.), 30 min before occlusion of the middle cerebral artery significantly reduced the volume of ischemic damage (from 32.7 ± 4.0% of the cerebral hemisphere in vehicle-treated cats to 16.2 ± 4.5% in MK-801-treated cats). NMDA receptor antagonists that penetrate the blood-brain barrier, such as MK-801, merit further study as protective agents against ischemic brain damage.
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Citations
Cited by
Siesjö, B. K., & Bengtsson, F. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.20 · Cited by 1,231
Two distinct oscillatory states determined by the NMDA receptor in rat inferior olive
Placantonakis, D. G., & Welsh, J. P. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-1-00123.x · Cited by 49
Metadata
- Authors
- Ozyurt, E., Graham, D. I., Woodruff, G. N., & McCulloch, J.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1988-02
- Volume
- 8
- Issue
- 1
- Pages
- 138-143
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2012555960
- Cited by
- 368
- References
- 0
- FWCI
- 40.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat. https://app.cochat.ai/papers/10.1038/jcbfm.1988.18
- The paper
- Ozyurt, E., Graham, D. I., Woodruff, G. N., & McCulloch, J. (1988). Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.1988.18
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
